Grant Pellowe

If you are a talented ECR, based outside of the UK, send us your CV. Accelerate your research career in our world class multidisciplinary research environment.
AIME want to support your fellowship applications
www.aston.ac.uk/research/aime @astonuniversity.bsky.social @astonaime.bsky.social

The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis Large oligomeric proteins constitute a major fraction of proteomes, but are difficult to refold in vitro, raising the question of how cells direct their biogenesis. Roeselová and Shivakumaraswamy et a...

Our latest cotranslational folding story is now published @cp-molcell.bsky.social. Really cool (I think) new ideas about how exactly the ribosome directs folding and assembly to make sure complicated proteins mature efficiently in cells.
www.cell.com/molecular-ce...

If anyone is interested in making bacterial ribosome-nascent chain complexes and studying them using HDX-MS, we have written up a detailed protocol.
rdcu.be/eYFx4
Characterise the conformational dynamics of the ribosome, nascent polypeptide and bound chaperones, label-free and at peptide-level

Hydrogen/deuterium exchange mass spectrometry analysis of ribosome-nascent chain complexes to study protein biogenesis at the peptide level Nature Protocols, Published online: 12 January 2026; doi:10.1038/s41596-025-01279-wA strategy for isolating Escherichia coli ribosome–nascent chain complexes and analyzing their conformational dynamics and interactors at peptide level using hydrogen–deuterium exchange mass spectrometry is presented.

New Article! Hydrogen/deuterium exchange mass spectrometry analysis of ribosome-nascent chain complexes to study protein biogenesis at the peptide level

GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome - Nature Communications The GroEL/ES chaperonin can act during protein synthesis to promote folding. Here, Roeselová et al. show how GroEL captures, remodels and sequesters nascent proteins in its central chamber, while they...

Our story on GroEL/ES action during cotranslational folding is now published @natcomms.nature.com. Led by former-student Alzbeta Roeselova, and in collaboration with Rado Enchev's lab @crick.ac.uk.
www.nature.com/articles/s41...

Biochemical Society's Membrane Protein Conference
7–9 April 2026
Birmingham, UK | Leonardo Royal Hotel

- Abstracts welcome for talks & posters
- Bursaries available!
- Register & submit here:
www.eventsforce.net/biochemsoc/f...

#MembraneProteins #CallForAbstracts @biochemsoc.bsky.social

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking Nature Structural & Molecular Biology, Published online: 19 September 2025; doi:10.1038/s41594-025-01676-5By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding interdomain misfolding.

New online: The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking

Delineating stages of Aquaporin biogenesis at Aston University on FindAPhD.com PhD Project - Delineating stages of Aquaporin biogenesis at Aston University, listed on FindAPhD.com

Re-advertising! Closes September 1st.

💧 Interested in understanding how Aquaporins fold into membranes as they're being synthesised? 💧

If so, come and do your PhD with me, @kitchenphil.bsky.social and @roslynbill.bsky.social at @astonaime.bsky.social

tinyurl.com/5dc23mu3

Reach out for details!

1 week to go - get your applications in!

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking https://www.biorxiv.org/content/10.1101/2024.09.19.613857v1 Proteins with multiple domains are intrinsically prone to misfold, yet fold efficiently during their

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking https://www.biorxiv.org/content/10.1101/2024.09.19.613857v1

Delineating stages of Aquaporin biogenesis at Aston University on FindAPhD.com PhD Project - Delineating stages of Aquaporin biogenesis at Aston University, listed on FindAPhD.com

💧 Are you interested in understanding how Aquaporins fold into membranes as they're being synthesised? 💧

If so, come and do your PhD with me, @kitchenphil.bsky.social and @roslynbill.bsky.social at @astonaime.bsky.social!

www.findaphd.com/phds/project...

Reach out for further details!