Judi Simcox

Really thrilled to have our work on mitochondrial presequence strength out today @jcb.org. We establish quantitative parameters to better define "strong" and "weak" presequences both in vitro and in vivo. This work was spearheaded by the ever talented Youmian Yan, a BBSB graduate student in my lab.

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1

How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

☕ @mikelangelipid.bsky.social @olzmannlab.bsky.social & co identify a #LipidDroplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of #ferroptosis.
@berkeleymcb.bsky.social
bit.ly/49mTeyF

Here the authors propose that inhibition of the serine threonine kinase FAM20C in adipocytes may serve as a potential therapy for #T2D by restoring adipocyte health www.jci.org/articles/vie...

Leptin as a key driver for organ fibrogenesis Neutralizing leptin reduces inflammation and fibrosis in mice, suggesting a potential treatment for fibrotic diseases.

Here the authors further support the link between #leptin signaling and tissue #fibrosis demonstrating that a leptin-neutralizing antibody may be a promising therapeutic approach for reducing fibrosis in the kidney, liver, lung, heart, and blood vessels www.science.org/doi/10.1126/...

Familial hypercholesterolaemia is still inadequately diagnosed and undertreated, with many affected people remaining at high risk of early cardiovascular disease www.thelancet.com/journals/lan...
#familial #hypercholesterolaemia #ASCVD

#MedSky #EndoSky #CardioSky

Are you attending SACNAS NDiSTEM 2025!? Don't miss this awesome session about "How to Identify the Right Mentor for You" hosted by @greisha-ortiz.bsky.social @neuro-explorer-lc.bsky.social @luisci22.bsky.social and @joele-r.bsky.social. #NDiSTEM2025 #SACNAS #STEMResearch #PLI @sacnas.bsky.social 🧪🔬🥼

Classifying a distinct form of diabetes in lean individuals with a history of undernutrition: an international consensus statement Since 1955, a form of diabetes in lean, young (BMI <18·5 kg/m2, age <30 years) individuals with a history suggestive of undernutrition from before birth and throughout childhood has been described in ...

Published in @lancetgh.bsky.social
Classifying a distinct form of #diabetes in lean individuals with a history of undernutrition: an international consensus statement www.thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky

Effects of Glucagon-Like Peptide 1 Receptor Agonist Initiation in Patients With Heart Failure With Reduced Ejection Fraction and Implantable Cardiac Devices:

Use of GLP-1 medicines in patients with HFrEF and implanted cardiac devices. Caution please www.jacc.org/doi/10.1016/...

Position-specific frequency matrices can be used to calculate z-scores comparing enzyme-treated and control samples. The z-scores are plotted as heatmaps that represent an enzyme specificity profile.

New preprint: we developed a method that uses phosphoproteome-derived peptide libraries (PhosPropels) for deep specificity profiling of phosphatases and phospholyases www.biorxiv.org/content/10.1...

Excited to share our new preprint, which was years in the making! chemrxiv.org/engage/chemr...
New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
1/n

Excited to share new work led by outstanding former grad student Kübra Akkaya! We show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell proliferation by balancing fatty acids, sustaining epithelial homeostasis and regeneration.

Special thanks to all co-authors and collaborators at OSU and Wisconsin, including @judisimcox.bsky.social , for their valuable contributions.

www.biorxiv.org/content/10.1...

a schematic of pancreatic beta and delta cells that explains how they turn glucose into activation and how these cell types signal to each other via gap junctions and G protein coupled receptors. The image has two stills of islet cells expressing fluorescent sensors for calcium and cAMP and of the same islet cells stained for the presence of the hormones insulin and somatostatin.

Very proud to see the main thesis work of the intrepid Dr. Mohammad Pourhosseinzadeh come out in @pnas.org today! In this paper, Mohammad assesses how crosstalk between insulin-secreting beta and somatostatin-secreting delta cells in the islet actually happens, in near real-time. A quick thread 1/10

We are hiring! Oxford biology has three associate professorships available as we move to new state-of-the-art facilities

Three Associate Professor (or Professor) positions available at Oxford Biology. Come be my colleague! www.biology.ox.ac.uk/article/we-a...

We have a thesis defense to celebrate today, but first - we need to celebrate the publication of former student Dr. Michaela Trautman's opus, "Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice" now in Mol Metab! www.sciencedirect.com/science/arti...

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...

Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...

How the fuck am I supposed to plan my lab finances if my grants keep getting terminated and reinstated and terminated again?

End rant.

Congratulations!!!!

The Sinha Lab The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.

I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu

People Caring for the Land: Volunteers, Communities, and Connection | UW Arboretum Spring brought abundant blossoms, greening of the prairie, songs of migratory birds, and many volunteer groups active on the land. In just thirteen weeks, nine different organizations carried out serv...

It was nice to see our lab’s retreat volunteer project be featured in the arboretum newsletter. We should all work to be stewards of the land we inhabit.

arboretum.wisc.edu/news/arboret...

We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime

Congratulations to @uwbiochem.bsky.social Alumni Brian Carrick for receipt of the Shurl and Kay Curci Fellowship from the LSRF!! Well deserved!

Great opportunity, the metabolism community in Utah is amazing. I miss my former colleagues daily! Killer research, collaborations, and investment in technology.

Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

Receiving an @endocrinesociety.bsky.social Early Career Investigator Award has been a highlight of my year. Thank you to the #Nicholaslab and all of my supporters, especially my gradschool and postdoc PIs. #ENDO2025 is my scientific home and I look forward to sharing our progress each year

Attie Honored with WARF Named Professorship Attie, a dedicated mentor and educator, has devoted his career to advancing our knowledge of diabetes and metabolism.

Congratulations to Professor Alan Attie on being recognized as the Henry & Annrita Lardy Professor of Biochemistry, a @warfnews.bsky.social Named Professorship. Attie has devoted his career to advancing our knowledge of metabolism. Read more: biochem.wisc.edu/2025/06/26/a...

#ENDO2025 has been the renewal of hope I needed. I feel the joy in seeing mentors including @intmedabel.bsky.social and Barbara Kahn, meeting up with friends, and seeing the transformation of the metabolic disease space. Onward to new discoveries. Thanks to #NIDDK for organizing our session.