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Afshin Samali

@afshinsamali.bsky.social

ER Stress, Unfolded Protein Response, Cancer Biology

51 Followers  |  81 Following  |  8 Posts  |  Joined: 21.01.2025  |  1.9254

Latest posts by afshinsamali.bsky.social on Bluesky

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Breastfeeding boosts immune cells that protect against breast cancer The protective, long-lived T cells can persist for decades after a woman gives birth.

Breastfeeding boosts anticancer immunity through recruitment of CD8+ T cells
www.nature.com/articles/d41...

22.10.2025 08:17 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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mRNA covid vaccines spark immune response that may aid cancer survival An analysis of patient records suggests that mRNA covid-19 vaccines boost the immune response to cancerous tumours when given soon after people start a type of immunotherapy, extending their lives

An analysis of patient records suggests that mRNA covid-19 vaccines boost the immune response to cancerous tumours when given soon after people start a type of immunotherapy, extending their lives

20.10.2025 16:44 โ€” ๐Ÿ‘ 11    ๐Ÿ” 6    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 2
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Why the next generation of mRNA vaccines is set to be even better

Scientists are designing mRNA vaccines to produce virus-like nanoparticles, which should lead to a more robust immune response with even fewer side effects than either of these immunisation approaches on their own

20.10.2025 18:45 โ€” ๐Ÿ‘ 15    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Blood tests are now approved for Alzheimerโ€™s: how accurate are they? A second blood test has been been approved by the US Food and Drug Administration to assist in diagnosing Alzheimerโ€™s disease. Will these tests change how cognitive decline is measured?

A new blood test has been been approved by FDA to assist in diagnosing Alzheimerโ€™s disease.
go.nature.com/47b4hIp

18.10.2025 00:04 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Blood tests are now approved for Alzheimerโ€™s: how accurate are they? A second blood test has been been approved by the US Food and Drug Administration to assist in diagnosing Alzheimerโ€™s disease. Will these tests change how cognitive decline is measured?

A new blood test to aid with the diagnosis of Alzheimerโ€™s disease has been approved by the US FDA

go.nature.com/47b4hIp

17.10.2025 13:25 โ€” ๐Ÿ‘ 42    ๐Ÿ” 16    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 1
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Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry Cells rely on the Unfolded Protein Response (UPR) to maintain ER protein homeostasis (proteostasis) when faced with elevated levels of misfolded and aggregated proteins. The UPR is comprised of three ...

Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry - Molecular & Cellular Proteomics www.mcponline.org/article/S153...

25.07.2025 17:15 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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This gene causes obesity โ€” and shields against heart disease People with certain forms of the MC4R gene have lower cholesterol levels than do other individuals with a high body-mass index.

Obesity gene shields against heart disease
www.nature.com/articles/d41...

17.10.2025 20:34 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Science Week Decorative graphic

Science Week Decorative graphic

The countdown to Science Week 2025 is on ๐Ÿ”ฌ๐Ÿ—“๏ธ

Supported by Research Ireland, Science Week is marking its 30th anniversary this year!

Festival and event details are coming soon! Stay tuned and keep an eye on www.scienceweek.ie for the latest updates.

#ScienceWeek #ThenTodayTomorrow

13.10.2025 12:51 โ€” ๐Ÿ‘ 6    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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More than 30% of this centuryโ€™s science Nobel prizewinners immigrated: see their journeys The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.

How #immigration drives winning #science - "Talent can be born anywhere, but opportunities are not" www.nature.com/articles/d41...

11.10.2025 11:33 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Since 2019, POI has worked to accelerate the development of personalised cancer therapy & diagnostic options. Today we begin Stage 2 of our journey, building on strong foundations and expanding our collaborations to drive innovation & shape the future of cancer care.

08.10.2025 15:10 โ€” ๐Ÿ‘ 4    ๐Ÿ” 3    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
Siobhan Gaynor, Advanced Cancer Patient Council member and patient researcher; Prof Donal Brenan, UCD Professor of Gynae-Oncology, Consultant Gynaecological Oncologist at the Mater Hospital, and Deputy-Director of POI; Prof Walter Kolch, Director of Precision Oncology Ireland and Systems Biology Ireland (based at UCD); Dr Siobhan Roche, Director of Science for the Economy, Taighde ร‰ireannโ€“Research Ireland; Prof Kate Robson Brown, UCD Vice-President for Research, Innovation and Impact.

Siobhan Gaynor, Advanced Cancer Patient Council member and patient researcher; Prof Donal Brenan, UCD Professor of Gynae-Oncology, Consultant Gynaecological Oncologist at the Mater Hospital, and Deputy-Director of POI; Prof Walter Kolch, Director of Precision Oncology Ireland and Systems Biology Ireland (based at UCD); Dr Siobhan Roche, Director of Science for the Economy, Taighde ร‰ireannโ€“Research Ireland; Prof Kate Robson Brown, UCD Vice-President for Research, Innovation and Impact.

Minister James Lawless has launched Phase 2 of Irelandโ€™s leading and largest ever cancer research programme, @precisiononcire.bsky.social. The programme is co-funded through Research Ireland, industry and the not-for-profit sector. Read more: www.researchireland.ie/news/precision-oncology-ireland/

08.10.2025 15:04 โ€” ๐Ÿ‘ 11    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Since 2019, POI has driven huge research impacts, from biological insights to training the next generation of researchers. On #WorldCancerResearchDay, weโ€™re proud to share our new brochure, developed with science journalist Claire O'Connell, highlighting these achievements

tinyurl.com/jnhs762h

24.09.2025 10:10 โ€” ๐Ÿ‘ 2    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Trump links autism and Tylenol: is there any truth to it? The US president repeatedly advised people, โ€œDon't take Tylenol,โ€ but scientists say that strong evidence between the medication and autism is lacking.

No strong evidence for autism-Tylenol link. www.nature.com/articles/d41...

24.09.2025 11:37 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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FEBS Press Although publication in scholarly peer-reviewed journals remains the gold standard for communication of findings in the life sciences, the gold has been debased by various impurities. Here, I discuss...

Five problems plaguing publishing in the life sciencesโ€”and one common cause - Wright - 2024 - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...

17.09.2025 11:04 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Samali Foundation will be honoured for its work at the Mayo Irish Diaspora Society 2025 Awards ceremony, tomorrow 13 September, #Castlebar #Mayo.

12.09.2025 17:01 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Excited to share our @narjournal.bsky.social work on a trackable trinuclear platinum complex for breast cancer therapy: doi.org/10.1093/nar/... ๐Ÿงฌ
With @raphael-depaiva.bsky.social @afshinsamali.bsky.social @alicepyne.bsky.social @westerlundlab.bsky.social @researchireland.ie @dcuresearch.bsky.social

17.07.2025 17:11 โ€” ๐Ÿ‘ 7    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Galway hotel fire โ€˜pulled our community together to help other newcomersโ€™, says professor Cancer specialist recalls 2023 incident as he launches foundation to help refugees and asylum seekers access education

It was lovely to interview with @sorchapollak.bsky.social @irishtimes.com regarding @samalifoundation.bsky.social
#Education #Refugee
www.irishtimes.com/ireland/soci...

23.06.2025 11:12 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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Launch of Samali Foundation on 17 June @ria.ie. Speakers included Minister Colm Brophy, Pat Guiry (President @ria.ie), Enda O'Neill (@unhcr.org Ireland), @afshinsamali.bsky.social, @adriennegorman.bsky.social (@universityofgalway.bsky.social), Zarghona Hassani & Ismail Mohammed. #Refugee #Education

19.06.2025 15:21 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Former refugee on a mission to help others - Connacht Tribune - Galway City Tribune Former refugee on a mission to help others

Former refugee on a mission to help others connachttribune.ie/former-refug...

13.06.2025 12:01 โ€” ๐Ÿ‘ 10    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 2

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