Geert Carmeliet

Frank was a great and wonderful scientist, a real Renaissance man, passionate to advance science, very open-minded to other scientific domains, although critical, always providing novel ideas, but above all very amicable and honest. We will miss you Frank! My thoughts are with the family.

Interesting findings Nick!!

Congratulations Patricia and team!!

Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...

🚨 Where does lipid peroxidation kick off in ferroptosis? 🔥Excited to reveal ER-mitochondria contacts as hotspots of the lipid peroxidation cascade! Kudos to our Maria Livia Sassano @mariamls.bsky.social 🙏 to our amazing collaborators #Ferroptosis#contactsites#ER#mitochondria# doi.org/10.1038/s415...

Metabolic adaptations direct cell fate during tissue regeneration - Nature Metabolic enzymes of the tricarboxylic acid cycle, such as 2-oxoglutarate dehydrogenase, are differentially expressed in absorptive and secretory lineages, guiding cell fate establishment and offering...

www.nature.com/articles/s41...

Congratulations!!!

Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival - Cancer & Metabolism Background Enhanced glycolysis plays a pivotal role in fueling the aberrant proliferation, survival and therapy resistance of acute myeloid leukemia (AML) cells. Here, we aimed to elucidate the extent...

New paper from our lab! In this study, we show that AML cells critically depend on LDHA to maintain their NAD+/NADH balance. Congrats to first author Ayşegül Erdem and all co-authors! cancerandmetabolism.biomedcentral.com/articles/10....

We have re-openend this position for a post-doctoral fellow in our lab! Reach out if you have an interest in studying metabolism in cancer/stem cells and ideally have some mass spec experience. Please share!

Intracellular metabolic gradients dictate dependence on exogenous pyruvate Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...

I'm excited to share our latest story from the
@lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...

www.nature.com/articles/s42...

Metabolites are not genes. repeat, please!

Early Registration Deadline for the congress in Innsbruck!
REGISTER TO NOT MISS OUT
Register until the 23 March to get the early registration fee and seize the opportunity to share science with colleagues from all around the world.

www.ects2025.org/registration/

Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites Ambrosi and colleagues profile human skeletal stem cells (hSSCs) across ten fetal skeletal sites and from patients throughout adulthood, identifying, mapping, and functionally testing four distinct hS...

I feel extremely fortunate to have had the chance to learn from & work with Chuck Chan, building on some of his seminal discoveries and scientific vision. A truly 'chuckesque' manuscript by a wonderful collaborative & interdisciplinary team @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

Congratulations Tom, beautiful work!!
Great memory of Chuck!

Thanks to all co-authors for excellent collaboration and thanks to @kuleuven.bsky.social and FWO for funding.

Rhodoquinone carries electrons in the mammalian electron transport chain Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors de...

Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:

www.cell.com/cell/fulltex...

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol...

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis: Cell Metabolism www.cell.com/cell-metabol...

Congratulations!!

very interesting research and great mentor!!

Hi all, our lab will soon recruit a PhD student working within a very exciting MSCA Horizon Doctoral network working on ageing, UNION, which gathers some fantastic scientists. Please apply if your profile fits our project (see attached advert).
Looking forward to working with you!

Many thanks Sarah!

Thanks Joel: there must be many links between mechanotransduction and metabolically regulated pathways in this type of tissue: anabolic, mechano-sensitive and partly hypoxic 🙂😉.

Thus PPP-generated NADPH is critical to ensure chondrocyte functioning and bone lengthening.
Many thanks to all co-authors and the entire research team as well as to #FWO and @kuleuven.bsky.social (3/3)

We found that loss of G6PDH does not affect chondrocyte proliferation, but reduces NADPH, especially during differentiation: NADPH provides reducing power to safeguard oxidative protein folding, sustains proteostasis and protects against ferroptosis (2/3)

The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes Nature Metabolism - Loopmans et al. show that the pentose phosphate pathway in chondrocytes provides reducing power to ensure proteostasis necessary for bone lengthening.

Big congratulations to Shauni Loopmans for her excellent PhD research, now online in @natmetabolism.bsky.social. This study reveals that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival rdcu.be/d5Q65 (1/3)

⏰ Deadline is approaching (Feb 6!) to apply for scholarships + short talks for the Keystone meeting on metabolism in development!

keysym.us/KSMetabDev25

The meeting is May 7-9 in Beverly, MA and will be a unique forum for discussing the role of metabolites in development. Hope to see you there!

Congratulations Ginevra with these very exciting findings!! and congratulations to the whole @fendtlab.bsky.social team!!