Alfonso De Stefano

Confirmed great data from #8HW trial at #ESMO25 with the combination NIVO+IPI confirms the standard of care option in 1st line MSI-H/dMMR mCRC patients @oncodaily.bsky.social

Intermittent or Continuous FOLFIRI + Panitumumab RAS and BRAF Wild-Type Metastatic CRC - OncoDaily Intermittent or Continuous FOLFIRI + Panitumumab RAS and BRAF Wild-Type Metastatic CRC / Akhil Santhosh, Alberto Sobrero, Alessandra Leone, Alfonso De

Thanks 🙏🏻 to @oncodaily.bsky.social to highlight the results of #IMPROVE trial Intermittent or Continuous FOLFIRI + Panitumumab RAS and BRAF Wild-Type Metastatic #CRC #GIonc #OncSky oncodaily.com/blog/panitum...

Tremelimumab and durvalumab as neoadjuvant or non-operative management strategy of patients with microsatellite instability-high resectable gastric or gastroesophageal junction adenocarcinoma: the INF... In resectable gastric/gastroesophageal junction adenocarcinoma, microsatellite instability-high (MSI-H) confers improved survival, but limited benefit…

Exciting #GIonc INFINITY ♾ #Ph2 trial

Neoadjuvant #IO in #stcsm #esocsm using #treme + #durva ~60% pCR

12m 🚫🔪#survival ~ 64%.

#Ph3 data needed, but organ preservation possible!

🔗: sciencedirect.com/science/arti...

#GI25 @ascocancer.bsky.social
For #colorectalcancer, there are many great abstracts-so this is just a few to🔦:
Pre-op:
1⃣@CQvortrup🗣️a Single-cycle of neoadj pembro for Stage I-III MMRdef CRC, Oral Abs 19
2⃣@jonathanloree🗣️using ctDNA🩸to support Non-Op management in rectal cancer, Oral Abs 20

#GI25 @ascocancer.bsky.social
The BIG trial in #colorectalcancer will be Scott Kopetz 🗣️BREAKWATER, the 1st line R-Ph3 trial of encorafenib + cetuximab + chemotherapy in BRAF V600E-mutant met CRC, Oral Abs 16

#GI25 @ascocancer.bsky.social
And 3 immunotherapy trials in #MCRC:
1⃣Thierry Andre🗣️the LBA of Ipi-Nivo vs Nivo of dMMR mCRC, ABS LBA143
2⃣ Marwan Fakih🗣️a Ph2 trial of BOT +/- Bal in MSS mCRC (no liver mets), Oral Abs 23
3⃣Joel R Hecht🗣️a Ph2 trial of a personalized Neo-Ant IO for MSS CRC, Abs LBA13

#GIonc summary
top 3 trials in #crcsm

🥇: NICHE-2 - 99% #ORR, 100% 3-year DFS in dMMR colon cancer with ⬇️ #tox
🥈: KRYSTAL-1 - adagrasib in KRAS G12C cancers ➡️ FDA approval + cetux
🥉: TransMet - transplant + 💉 improves 5y #OS

🔗: nature.com/articles/s41...

Neo-adjuvantFOLFOX+/- #panitumumab for pts with KRAS-wt locally advanced #coloncancer: FOxTROT Trial www.annalsofoncology.org/article/S092... ➡️ @jenseligmann.bsky.social #GIonc @oncoalert.bsky.social

👉⬇️recurrence 12% vs 21%(HR=0.51,p0.09),significant in EREG/AREG ⬆️
👉⬆️TOX G3 diarrhoea and rash

PD-1 blockade with Tislelizumab+chemoradiotherapy in unselected MMR locally advanced #rectalcancer
doi.org/10.1038/s415... @natmedicine.bsky.social
✅The pCR rates were 27.1%, 32.7% and 14.0% for experiment groups A and B and the control group C, respectively

FEBS Press Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are ...

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer 🧪 #PancreaticCancer febs.onlinelibrary.wiley.com/doi/10.1002/...

#GI25 @ascocancer.bsky.social
Finally, two additional abstracts to watch for in #cholangiocarcinoma:
1⃣Dr. Priyanshi Shah🗣️Long-term outcomes for MSI-H BTC patients on immunotherapy, Abs 592; Post#C18
2⃣Dr. Christos Fountzilas🗣️🎯FGFR in the Ph2 trial of Tinengotinib for BTC Pts, Abs 608; Post#D9

#GI25 @ascocancer.bsky.social
3⃣abstracts🔬outcomes of Pts with specific🧬alterations in #cholangiocarcinoma:
1⃣&2⃣look at MDM2amp BTC:
➡️Dr. Iyer, Abs 544; Post#A22
➡️Teresa Macarulla, Abs 615, Post#D16
3⃣Richard Kim🗣️Real-World OS in BTC Pts with IDH1mut or FGFR2fus + BTC, Abs 548; Post#A26

Many thanks to @mpishvaian.bsky.social to share his top abstract titles of the upcoming #GI25 @ascocancer.bsky.social #GIonc

Anti-EGFR re-challenge with chemotherapy in RAS wild-type advanced colorectal cancer (A-REPEAT study): efficacy and correlations with tissue and plasma genotyping Approved treatments for colorectal cancer (CRC) patients pretreated with two lines of therapy are of limited efficacy. Anti-epidermal growth factor re…

A-REPEAT trial: #panitumumab based #rechallenge strategy in pretteated metastatic #crc pts. The study was closed prematurely but highlights the importance of #LiquidBiopsy before rechallenge:48% of pts were RAS mutant #GIonc #OncSky @christianrolfo.bsky.social www.sciencedirect.com/science/arti...

The OncoAlert🚨 Network along with our partners at
ESSO, ESGO, MASCC & SIOG
invite you to the #OncoAlertColloquium

REGISTER for FREE HERE👉 buff.ly/3CChgre
February 3-9, 2025 💯% Virtual & Interactive

@erikahamilton9.bsky.social
@drsgraff.bsky.social
@drjnaidoo.bsky.social
@hoperugo.bsky.social

Interesting review on advances in targeting 🎯#KRAS in #mCRC Development of KRAS Inhibitors and Their Role for Metastatic Colorectal Cancer
by Dr.Dustin Deming on #JNCCN
jnccn.org/view/journal... @oncoalert.bsky.social @oncodaily.bsky.social @medicalwatch.bsky.social

2024 FDA approvals The FDA approved 50 new therapeutics in 2024, with green lights for a novel schizophrenia drug, a first NASH medicine and much more.

www.nature.com/articles/d41...

The Landscape of @fda.gov drug approvals in 2024. 30% Oncology novel drugs !

Happy New Year to everyone! @oncodaily.bsky.social @oncoalert.bsky.social
@medicalwatch.bsky.social
@katesears.bsky.social

📢Very useful suggestions from @medicalwatch.bsky.social @katesears.bsky.social directly forwarded to your📁📬email. You can subscribe to get a monthly update on phase 3 interventional clinical trials recruiting near you on your field of interest. Congrats and thanks for this project!👏🏻💪🏻 #OncSky #GIonc

Another issue on the role of #LiquidBiopsy in #CRC 👉 In these patients with stage II-IV CRC who underwent curative-intent resection,the benefit of adding serial tumor-informed ctDNA assay to the standard surveillance was limited #ISLB #GIonc @oncoalert.bsky.social
jamanetwork.com/journals/jam...

Dear Colleagues,
Wishing you hashtag#MerryChrismas2024 & Happy Holidays from All of us at OncoAlert 🚨

@elisaagostinetto.bsky.social
@drjnaidoo.bsky.social
@lymphomadoc.bsky.social
@realbowtiedoc.bsky.social
@stephenvliu.bsky.social
@drlestercoll.bsky.social
@erikahamilton9.bsky.social

Find the results in the open access paper on #JCO @ascocancer.bsky.social at ascopubs.org/doi/pdf/10.1... #OncSky #GIonc

Find the results in the open access paper on #JCO @ascocancer.bsky.social at ascopubs.org/doi/pdf/10.1...

🙏🏻 Grateful to @medicalwatch.bsky.social and @katesears.bsky.social to promote the results of IMPROVE trial ascopubs.org/doi/pdf/10.1... in the weekly newsletter! To be always updated on most recent trials, you can subscribe at my.medical.watch/signup

A very interesting course here in Italy, very recommended to all oncology researchers @ascocancer.bsky.social

#IMPROVE trial #Intermittent (I) or #Continuous (C) Panitumumab+FOLFIRI for First-Line Treatment of RAS/BRAF WT Metastatic Colorectal Cancer #oncsky #JCO

✅ Endpoint met
👉mPFS 11.2(C)vs17.5 months(I)
👉NO detrimental effect on OS
👉DCR 94.2%(C)vs91%(I)
👉Reduced toxicity
ascopubs.org/doi/pdf/10.1...

FDA grants accelerated approval The Food and Drug Administration granted accelerated approval to encorafenib.

@oncoalert.bsky.social @medicalwatch.bsky.social Historic milestone 🎯🥇 for first-line #mCRC treatment of #BRAF V600E mut patients based on #BREAKWATER study: FDA grants Accelerated Approval to Encorafenib Plus Cetuximab and Chemo for BRAF V600E+ mCRC patients #GIonc www.fda.gov/drugs/resour...

FDA grants accelerated approval The Food and Drug Administration granted accelerated approval to encorafenib.

The FDA has approved BRAFTOVI in combination with cetuximab and mFOLFOX6 for first-line treatment in patients with metastatic colorectal cancer with a BRAF V600E mutation. The approval is based on the BREAKWATER study, for which MD Anderson’s Dr. Scott Kopetz is co-PI. 1/2

Great milestone 🎯🥇 for #mCRC treatment #GIonc #OncSky based on the last update clinicaltrials.gov/study/NCT046... FDA grants Accelerated Approval to Encorafenib Plus Cetuximab and Chemo for BRAF V600E+ Metastatic Colorectal Cancer www.fda.gov/drugs/resour...

Accelerating Innovation in Biliary Tract Cancer | LinkedIn Join Us for a Live In-Person and Virtual Symposium on "Accelerating Innovation in Biliary Tract Cancer" during the 2025 ASCO® Gastrointestinal Cancers Symposium. 📅 Thursday, January 23, 2025 🕤 6:00-6...

Join Drs. Abou-Alfa, Goyal, Harding, & Prof. Vogel for a PeerView Live Symposium in collaboration with the CholangiocarcinomaFoundation.org during the #GI25
📅 Jan 23, 2025
🕕 Reg & Dinner: 6:00 PM PST
🕡 Symposium: 6:15 PM PST / 9:15 PM EST
📍 In-Person & Virtual
#Medsky #Oncsky