Hiten Madhani

Nice day for a ride!

CDC advisory panel rolls back universal hepatitis B vaccine recommendation The change upends decades of Centers for Disease Control and Prevention guidance and goes against widespread public health consensus.

Remember: RFK Jr. fired his last CDC director because she refused to ram through his anti-vax agenda.

Yesterday, RFK Jr.’s handpicked vaccine skeptics threw out DECADES of settled science — and Donald Trump gave a thumbs-up.

This will hurt American kids and families.

Grantflation. If only the budget was coupled to the science CPI.

grants.nih.gov/grants/guide...

Re-upping my Bluetorial about VAERS which is the likely source of these cases.

bsky.app/profile/jere...

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Rapid compensatory evolution within a multiprotein complex preserves telomere integrity Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...

How to keep in step when your (protein) partner speeds up…

Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.

Congrats to whole team!

www.science.org/doi/10.1126/...

National Academies - Statement on CDC’s Updated Vaccine Guidance National Academies respond to CDC’s updated vaccine guidance, offering scientific context and clarity on vaccine safety.

Appreciate @nationalacademies.org speaking up about the RFK jr directed changes to CDC website and pointing out that the science cited did not include the greater context or full body of research. Where is the “radical transparency”?

Unfortunately I am…

Establishment of a Congenic Strain for the Oyster mushroom reveals the Structure and Evolution of Mating-Type Loci https://www.biorxiv.org/content/10.1101/2025.11.21.689727v1

Fantastic seminar on 'chromatin regulation and evolution' by @hitenmadhani.bsky.social at @ucriverside.bsky.social
Loved how he started with the classic Linaria vulgaris epigenetics example 🌱

🙏

Cloudy (but nice) day for a ride!

Senator Murray Slams Outrageous Political Retaliation at NIH, Demands Answers from Trump Administration - Senator Patty Murray Vice Chair Murray in June to NIH Director Bhattacharya: “You just received a letter signed by hundreds of your own staff who believe this administration’s actions risk breaking NIH and the lifesaving ...

Great to see continued leadership from @murray.senate.gov

www.murray.senate.gov/senator-murr...

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MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.

Or from a single dish of HEK cell culture in the case of two membrane proteins.

Out in Nature Methods now! lnkd.in/gpyBSceg

Wonderful collaboration with the Efremov lab.

Michael is my neighbor and a wonderful, courageous person. When Nazis left anti-Semitic leaflets on people’s cars, he organized a neighborhood sign-making session and led people in posting the signs communicating our solidarity against hate.

a man wearing a red shirt with the letter w on it says " who are we if we don 't even try " ALT: a man wearing a red shirt with the letter w on it says " who are we if we don 't even try "

I realize that these timelines are absurd and wanting to take on one of these important positions under the present circumstances is problematic, but NIH needs qualified applicants to apply.

Please consider applying, even if you are not sure you would accept the position if offered.

3/3

Alert for scientists: NIH institute director vacancies are posted! Please apply so we get actual scientists in these positions instead of just political appointees!!!!

Nice day for a ride!

Nice day for a stroll! 70 and clear. Not bad for November.

Nucleosome socks from the 5th biannual @epicypher.bsky.social meeting!

I have had the (perhaps dubious) honor of giving the final talk at last four. Great meeting as usual. Thanks to Michael and the gang for putting it together.

Raise a glass for Rosalind Franklin tonight and honor her memory and scientific contributions

8 high level positions at NIH posted including 6 institute director positions (NIMH, NIGMS, NICHD, NIDCR, NHGRI, NLM).

Only open for 2 weeks (applications due November 21).

Application materials include a) CV b) vision statement c) a photocopy of doctoral degree.

hr.nih.gov/careers/open...

In case anyone is wondering if Watson was really THAT bad, @lpachter.bsky.social compiled a list of quotes that are absolutely not for the faint of heart.
liorpachter.wordpress.com/2018/05/18/j...

Congratulations Wendy. Not surprised that you were awarded of course. 😎

Vivid reminder that HHS sec is not an MD.

Absolutely, this.

I did not intend to bury the lede in my data nerdiness.

Sad news indeed. I only knew Zara at ‘smile, wave and say hi’ level, but she always smiled, waved and said hi and always I did the same.

University of Pittsburgh professors push back against Trump 'compact' for higher education University of Pittsburgh professors have asked their school to reject a Trump "compact" that promises more access to federal resources to schools that sign on to his agenda

Pitt faculty taking a stand against the higher education "compact"

www.wesa.fm/identity-com...

I know of a few other news stories about similar faculty action.

Please share them here.

Expert Warns of Irreparable Damage to Biotech Industry Unless Congress Acts U.S. owes its 'vibrant pipeline' to high levels of public funding, says Aaron Kesselheim

From Senate hearing on Wednesday

www.medpagetoday.com/washington-w...

The value of public R&D

Government has published one of those quiet but important documents that might get overlooked as it is not 'newsy'. The headline finding is that £1 of public R&D investment generates £8 in net economic benefits for the UK over the long term
www.gov.uk/government/p...

Good to see Nature recognize fundamental research. Honestly, it’s the only kind that has ever floated my boat. Everything else just seems boring to me and I would rather live an interesting life. And, of course, as argued in the piece, it has an outsized impact.