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GoffinetLab

@goffinetlab.bsky.social

Chair in Virology @LSTM, UK | HIV-1, alphaviruses, SARS-CoV-2, MPXV | AIVE - Antiviral Immunity and Viral Evasion | Alumna of Charité - Universitätsmedizin Berlin, Germany https://www.lstmed.ac.uk/about/people/professor-christine-goffinet

870 Followers  |  234 Following  |  29 Posts  |  Joined: 12.10.2023  |  2.1901

Latest posts by goffinetlab.bsky.social on Bluesky

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Heading home after a rich day full of science at @institutpasteur.bsky.social. Warm thanks to @julianbuchrieser.bsky.social and Olivier Schwartz for the kind invite!

10.01.2026 07:15 — 👍 5    🔁 0    💬 0    📌 0
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Synergistic latency reversal by the SMAC mimetic AZD5582 and iBET JQ1, combined with Nef ablation, facilitates immune-mediated elimination of latently HIV-1-infected T-cells Recent breakdowns in the supply chains of antiretroviral therapy (ART) to lower income countries, where they are needed most, underpin the pressing need for an accessible and scalable HIV cure that wo...

www.biorxiv.org/content/10.1...

23.12.2025 19:10 — 👍 1    🔁 0    💬 0    📌 0
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Type I interferons sensitise HIV-1-reactivating T-cells for NK cell-mediated elimination despite HDACi-imposed dysregulation of innate immunity Shock-and-kill is one of the most advanced, yet unrealized, concepts towards establishment of HIV-1 cure. Treatment with latency-reversing agents (LRAs), including histone deacetylase inhibitors (HDAC...

www.biorxiv.org/content/10.1...

23.12.2025 19:10 — 👍 1    🔁 0    💬 1    📌 0

3/ in "shock-and-kill" approaches, as we found (link to studies below). Indeed, the authors don't seem to generate evidence for detectable reduction of the reservoir size, and (temporal) virus control seems to be achieved predominantly by T-cell responses. #HIVCure is not around the corner!

23.12.2025 19:10 — 👍 1    🔁 1    💬 1    📌 0

2/ special profile from start on which may potentially have facilitated things). I really do wonder if the chosen LRA, the TLR9 agonist lefitolimod, modulates cell surface Env presentation (important for ADCC), and/or apoptosis. Many (but not all!) LRAs do, and paradoxically impede "kill"

23.12.2025 19:10 — 👍 1    🔁 1    💬 1    📌 0

1/ I agree that (even functional) #HIVCure will probably need a multi-component and staged strategy, and is not close. This multi-pronged approach shows, 18 months post ATI, a delay of viral rebound in 6/9 participants, and remission in 1/9 participants (though the latter seems to display a

23.12.2025 19:10 — 👍 1    🔁 1    💬 1    📌 0

Definitely exciting and even more puzzling. Note that the patient himself was heterozygous for CCR5delta32. So either there is a dosage effect of truncated CCR5, and/or (more provocative) the CCR5 genotype is less relevant than we all anticipated and the allo-SCT per se does large part of the trick?

23.12.2025 18:09 — 👍 2    🔁 1    💬 1    📌 0
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Last month, my team had the great pleasure of hosting a fantastic guest PhD student, Bridget Fisher, from Sharon Lewin's lab at The Peter Doherty Institute for Infection and Immunity, for our collaborative work on #HIVCure. Looking fwd to continuing this exciting joint study. Very well done Bridget!

23.12.2025 17:25 — 👍 5    🔁 1    💬 1    📌 0

Absolutely privileged to have met Michel Sidibé, AU Envoy for African Medicines Agency, former @unaids.org Director & Mali Health Minister. Our chat spanned topics ranging from #HIVcure development to implementation. Should a cure be discovered, do we have systems to ensure equitable access?

10.12.2025 17:12 — 👍 4    🔁 0    💬 0    📌 0
Dylan Postmus giving a presentation on his work at the RetroPATH meeting

Dylan Postmus giving a presentation on his work at the RetroPATH meeting

View from a boat ride on the Neckar River in Tübingen, Germany.

View from a boat ride on the Neckar River in Tübingen, Germany.

Had an excellent time at this year’s #RetroPATH2025 meeting in Tübingen, Germany, talking about my work on #HIVcure. Many thanks to @agschindler.bsky.social and Daniel Sauter for hosting. Especially interesting was the variety of talks on #HERVs @goffinetlab.bsky.social @lstmnews.bsky.social

19.10.2025 21:16 — 👍 5    🔁 2    💬 1    📌 0

I am very pleased to be hosting @goffinetlab.bsky.social from @lstmnews.bsky.social tomorrow, sponsored by @infect-net.bsky.social

📣: Feodor-Lynen lecture hall @genecenter-lmu.bsky.social
🕙 18.9. 1:00 pm

17.09.2025 12:02 — 👍 4    🔁 1    💬 0    📌 0

Many thanks Prof Henry Mwandumba and Prof Kondwani Jambo & teams for the warm welcome and hospitality at Malawi Liverpool Wellcome Research Programme, Blantyre. We had fantastic discussions and developed prospects for collaboration on #HIVCure. A truly inspiring visit!

08.09.2025 17:42 — 👍 8    🔁 2    💬 0    📌 0
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We had a great time hosting three college students - Sadie, Chloe and Isobel - as part of the In2STEM programme with Dr Kelly Johnston. With @dylanpostmus.bsky.social, they learned about our work in #HIVCure, drug development pipelines and assay design. Check out the programme here: in2scienceuk.org

11.08.2025 08:57 — 👍 2    🔁 1    💬 0    📌 0
Julia Prigann, PhD | UCSF-Bay Area Center for AIDS Research (CFAR)

Congratulations to @juliaprigann.bsky.social for being awarded the 2025 CFAR Excellence in Basic/Translational Science Award!
cfar.ucsf.edu/user/11703

17.07.2025 17:16 — 👍 2    🔁 1    💬 0    📌 0

En route pour Lyon. Je me réjouis de présenter quelques snapshots de notre recherche @lstmnews.bsky.social sur le Chikungunya virus #CHIKV et son interaction avec le système immunitaire inné! #JFV2025

23.04.2025 17:02 — 👍 4    🔁 1    💬 0    📌 0
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An inspiring meeting #KSHIV25 in Durban ends. Great presentation by @dylanpostmus.bsky.social on why many LRAs for #HIVCure are imperfect. A pleasure meeting the next promising generation of African ECRs, speaking to old friends and making new ones. Plus the daily sunrise over Indian Ocean!

10.04.2025 19:38 — 👍 4    🔁 1    💬 0    📌 0

Shout-out to @dylanpostmus.bsky.social speaking at #MicroBio25. Just in time before heading to Keystone Symposium on #HIVCure keysym.us/KSHIV25
Stay tuned!

04.04.2025 15:17 — 👍 5    🔁 0    💬 0    📌 0

Happy to be part of the EU consortium DEFENDER @horizoneu.bsky.social and contribute to discovery of novel entry factors of #CHIKV, laying the ground for development of antiviral therapies @lstmnews.bsky.social

25.03.2025 08:54 — 👍 4    🔁 1    💬 0    📌 0
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#InternationalWomensDay2025
“When I’m sometimes asked 'When will there be enough?’ and I say ‘When there are nine,’ people are shocked. But there'd been nine men, and nobody's ever raised a question about that.”
Ruth Bader Ginsburg
1933-2020

08.03.2025 09:55 — 👍 12    🔁 4    💬 0    📌 0
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It was a pleasure attending #GfV2025 in Hamburg today and chairing the Innate Immunity Plenary today together with @sparrerlab.bsky.social with fantastic keynotes by Adolfo García-Sastre, @scheellab.bsky.social and Michaela Muller-Trutwin. Thanks for coming!

07.03.2025 12:36 — 👍 13    🔁 2    💬 0    📌 0

Due to high interest in the role, the ad will be kept live until March 9th:

25.02.2025 12:00 — 👍 0    🔁 0    💬 0    📌 0

Deadline for submission of applications for the role of Chair in Immunology at @lstmnews.bsky.social is March 2nd 👇

13.02.2025 20:52 — 👍 0    🔁 0    💬 0    📌 0

Join me at the LSTM in Conversation Webinar with Barry Atkinson @ukhsa.bsky.social and @gsrajahram.bsky.social in less than two days!
Sign up via the link in the description 👇

10.02.2025 19:01 — 👍 5    🔁 4    💬 0    📌 0

Of course, costs for Skilled Worker VISA application and NHS surcharges will be covered by LSTM.

29.01.2025 22:18 — 👍 0    🔁 0    💬 0    📌 0
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Professor of Immunology | Liverpool School of Tropical Medicine Professor of Immunology Based in Liverpool, with flexible working opportunities available   Liverpool School of Tropical Medicine (LSTM) is a globally recognised centre of excellence for research and...

We @lstmnews.bsky.social are looking to appoint a Professor of Immunology with strong record in human pathogen and/or tropical disease research for translation of basic science into tangible solutions for the patients affected by global health challenges:
app.vacancy-filler.co.uk/salescrm/Car...

29.01.2025 19:32 — 👍 8    🔁 6    💬 0    📌 3
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Post-Doctoral Research Associate (88593) | Liverpool School of Tropical Medicine Full-time, Fixed-term appointment to 30th September 2027   The Liverpool School of Tropical Medicine (LSTM) is a world-leading institution dedicated to improving health through research, education, a...

📢Post-Doctoral Research Associate Position (2.5 years with prospect of extension) on alphavirology at @lstmnews.bsky.social, Liverpool, UK - Characterisation of cellular entry inhibitors of #CHIKV within starting @horizoneu.bsky.social Consortium DEFENDER📢
app.vacancy-filler.co.uk/salescrm/Car...

29.01.2025 17:22 — 👍 8    🔁 7    💬 1    📌 0

Happy to be part of the new Horizon EU consortium DEFENDER and to start characterising CHIKV-modulating cellular factors and their druggability!

15.01.2025 17:17 — 👍 3    🔁 0    💬 0    📌 0
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Professor of Immunology | Liverpool School of Tropical Medicine Professor of Immunology Based in Liverpool, with flexible working opportunities available   Liverpool School of Tropical Medicine (LSTM) is a globally recognised centre of excellence for research and...

@lstmnews.bsky.social is recruiting a Full Professor in Immunology. If you are interested in developing a competitive and impactfull research programme in the field of immune control of tropical diseases, in a vibrant scientific environment, please reach out!
app.vacancy-filler.co.uk/salescrm/Car...

05.12.2024 15:01 — 👍 0    🔁 0    💬 0    📌 0

Will make sure to provide support for VISA/IHS costs

19.10.2023 11:30 — 👍 0    🔁 0    💬 0    📌 0

💥 Postdoc position advert in the making (to be filled early 2024 Liverpool School of Tropical Medicine): if you are interested in investigating arthritogenic alphavirus infections in human cells and mosquitoes, with a focus of cell-intrinsic innate immunity, sensing and viral evasion, stay tuned 💥

19.10.2023 11:29 — 👍 1    🔁 1    💬 1    📌 0

@goffinetlab is following 20 prominent accounts