Tudor Selescu

Yes, birds shake after dust bathing to clean their plumage. Here we only investigated the contribution of the cold receptor TRPM8 to triggering shaking. Mechanical receptors are also involved. Watch Supplementary Movie 8 from our article, where semolina powder was sprinkled on the back of a chicken.

Chickens respond to Cryosim-1 with a "wet dog shakes"-like behavior.

TRPM8 is required for the shorter "wet dog shakes" latency in cold water-sprayed mice.

Cryosim-1 is more selective for TRPM8 in mouse DRG neurons than WS-12 (Acoltremon).

We show that simultaneous pharmacological and temperature stimulation can be used to identify efficacious TRPM8 agonists.

We know that wet dogs will shake. How about birds? And is cold-sensing relevant? Our article on TRPM8's role in the shaking of mammals and birds was recently published in Communications Biology.
Below you'll find a selection of our findings. More in the article: www.nature.com/articles/s42...