AZ Faust

❌ Research

Folks, if your Aim 1 does not move the mechanism past what you already knew from your preliminary data, it's a bad Aim. It should answer an outstanding question (and by outstanding, I mean "pending" not "awesome") after one knows your preliminary results.

When you've shaped yourself to be a hammer, every situation looks like a nail...

We’ve had grants picked up (as in excited but panicked phone call from PO about getting our JIT in yesterday) in late August. Not that I’m saying that’s common or frequent, but it does happen. Of course, that was in normal times when all systems were functioning properly

Years ago my youngest asked me if we had magic, and I blurted out “No, we have science.”

Something genuinely surprising to me — the unemployment rate for college grads is higher than it was the month Lehman went bankrupt:

I continue to be annoyed at phrasing like this, because it suggests that it is possible to change facts. Facts cannot be changed. They remain stubbornly true, and are completely impervious to whether anyone knows them, publishes them, puts them in the report, etc.

Yeah, I thought about that too. Either scenario does not speak highly of his character.

What kind of a person abandons their life's work for power? What can one say about someone's character when they do such a thing?

JB made his career in health economics by studying health disparities. He was the head of a Stanford institute dedicated to health disparities research. I am not an expert in health economics or policy work, but if I look at his Google scholar page, some of his most cited works are in this space

This is probably the best summation of my original hopefulness around JB being named the NIH director, and my utter disgust at his words, actions, and inactions at the NIH so far.

I give it less than 12 months until the first job posting for an "AI fact checker" is out there.

As in, your job is to fact check the AI output.

And the worst of it is American science is being destroyed not because of any intrinsic issues, but rather because a cabal of traitorous, deeply unserious people decided to destroy it for the Lols and to own the libs

Agree, same experience here.

Maybe that was the differences, the PI in question was a new investigator.

I’m actually shocked they are still accepting R01s. Last time I talked to a PO from NIGMS they told me not to bother, to just submit a MIRA instead.

I'm so sorry.

Court accepting updated list of plaintiffs/grantees impacted! MUST BE SUBMITTED BY AUGUST 1st 5pm EST! Please disseminate!!!

Message from ACLU team below:

1/n

And my comments are not meant to criticize NIGMS - just to highlight that NIGMS and NCI had distinct funding philosophies that were reflected in their pay rates.

When they were still giving our R01s, they awarded 4 year, not 5 years R01s. They also got rid of "big" mechs (like P01s and while they have RM1s, they actively advised against applying for them). This all worked to keep their pay rates much higher than NCI.

NIGMS aggressively polices who "fits" under the NIGMS umbrella. They also have a very communist approach to funding - if your lab is too well funded (have more than $750K in extramural dollars), you don't get NIGMS money. You are also allowed one and only one NIGMS grant.

I know it may seem boring but it's also fascinating to see how much pCR rates can vary between different institutions.

As I am sitting here, digging into the literature about the real-world rates of a novel, standard-of-care therapy, I just want to say God bless all those medical residents whose mentors are like "lets just write a paper on outcomes of our patients to the SOC."

Don't get addicted to YouTube money kids. Those views may buy you a bigger house but it's not worth your soul.

He went from a needed voice criticizing poorly run clinical trials designed to guarantee drug success (regardless of patient benefit) to an RFK Jr and Trump sycophant all because the MAGA eyeballs on his social media. One of the saddest stories in medicine.

As I was writing that, my brain was thinking "yeah, I'll also take the tail end of that chart"

That 30% success rate of 1999-2000 looks like my wildest dream.

So many people revealed themselves either as sympathizers or accommodators. Anyway, these days, we know exactly who would be driving the bus to Auschwitz under the pretext of "just following orders."

Met a new investigator this morning and they go "At first I thought your business name was super clever. As in 'strike a faustian bargain.' But then I realized, 'oh sh*t, that's her actual name.'"

🤣🤣🤣

Is MAGA world convinced only libs get sick?

What am I saying, of course they are, they think Vitamin D and ivermectin cure everything.