Jan Lammerding - Lab

Home - Engineering Biology For Biomedicine Engineering Biology for Biomedicine A UKRI:BBSRC Centre for doctoral training Why EB4BM “ Our graduates bridge fundamental biological design principles with biomedical bottlenecks, delivering engineer...

Interested in a PhD in collective cell migration & mechanobiology?

I'm looking to support a candidate applying for a fully funded UK/Home PhD. The project studies the biophysics of migrating cells, using force measurements & optogenetics, with collaborators in Japan.

#mechanobiology #PhD
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Considering a graduate degree in biomedical engineering and wondering if a Master of Engineering degree is worth it? Join this virtual information session hosted by the Meinig School of Biomedical Engineering at Cornell University: www.duffield.cornell.edu/bme/meng/
MEng applications are still open!

Great summer research opportunity for undergraduate students interested in cardiovascular research at Cornell BME. Projects range from tissue engineering and cardiac device to disease models and spatial & single cell transcriptomics.
Apply at: www.cnf.cornell.edu/education/re.... Please share.

New undergraduate summer research opportunities in cardiac research and biomedical engineering at the Cornell Meinig School of Biomedical Engineering, sponsored by the American Heart Association. Apply by Feb. 28 at www.cnf.cornell.edu/education/re.... Please share.

Inserting the novel lamin A/C emerin-binding domain into lamin B, which normally does not bind emerin, is sufficient to anchor emerin to the nuclear envelope. The novel emerin-binding domains acts in addition to the well established emerin-binding domain in the lamin A/C tail.

Preventing lamin A/C polymerization, or using lamin A/C truncations that bind to the nuclear membrane but are unable to form filaments, is sufficient to ensure nuclear emerin localization, but insufficient to keep it firmly in place.

This work, led by fantastic Cornell BMCB PhD graduate Jacob Odell, and with support of Kristen Nedza, we show that lamin A/C has not one, but two independent emerin-binding domains, and that lamin filaments are required to ensure emerin localization to the nuclear envelope and anchor it in place.

Lamins A and C is required to anchor emerin at the nuclear envelope, and mutations in these proteins cause devastating diseases such as Emery-Dreifuss muscular dystrophy (EDMD). In work now available in #JBiolChem at www.jbc.org/article/S002..., we identify a novel lamin A/C-emerin binding site.

Very exciting work from @maggieutgaard.bsky.social in the Beach & Oakes labs pointing to a novel mechanoresponsive roles of septins in protecting the nucleus from mechanical stress. Enjoy the science, and the beautiful movies!

Negin Majedi delivering a fantastic kick-off presentation on the #mechanobiology of cancer immune engineering as part of the new #MechanobiologyHub seminar series hosted by the @weillinstitute.bsky.social at Cornell University.

Attending the ASCB/EMBO Cell Bio #cellbio2025 in Philadelphia? Check out the posters from our lab on nuclear mechanobiology, lamins, and mechanotransduction today and on Tuesday. I will be there too and look forward to catching up!

Good eye! Yes, it’s 2um wide and 5um tall, very similar to some of the smaller interstitial spaces in vivo.

Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social

Thanks to @katemiro.bsky.social , Megan King, Verena Ruprecht & @lammerdinglab.bsky.social for organising the very first meeting on the “Mechanobiology of the Nucleus” #MBNSRC @faseborg.bsky.social and for the invitation to present our discoveries. The conference was fantastic!

Thanks so much! We were delighted to have you as a speaker! Looking forward to the next one in two years!

Congratulations!!

It’s been a pleasure working with @apdaria.bsky.social, Julie Heffler, and the Prosser Lab on this study, supported by the Leducq Foundation and the National Institutes of Health (NIH). This research is one step to get us closer to an effective treatment for cardiac #laminopathies and #LMNA-DCM.

Registration is still open, and abstracts for posters are still accepted (email me for info or questions)!

Congratulations!!

A big thank you for the GENEROUS support, although general support is good too! :)

A big Thank You to the general support from the NIH-NHLBI, the Leducq Foundation, the American Heart Association @ahascience.bsky.social, a Fleming Research Fellowship, and the Mills family.

Expression of a dominant negative nesprin domain, DN KASH, which disrupts the LINC complex, reduces forces on the nucleus, reduces nuclear envelope rupture, and restores expression of many dysregulated genes. DN KASH expression also rescues cardiac function and extends survival by >1 year.

Detailed transcriptomic analyses indicate that a subset of cardiomyocytes drives disease progression by expression of genes associated with sterile inflammation, likely downstream of nuclear envelope rupture and activation of cytosolic DNA sensors, independent of cGAS/STING.

How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.

A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites Lamins form a dense meshwork at the inner surface of the inner nuclear membrane (INM), where they interact with other nuclear envelope proteins such as emerin. Emerin is an integral membrane protein t...

Odell, J et al. (@lammerdinglab.bsky.social lab) A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites. bioRxiv posted 2 September 2025 doi:10.1101/2025.09.01.673543. www.biorxiv.org/content/10.1...

Thanks so much for highlighting our work!

I should point out that the conference is held in Melbourne, Florida, not Australia!

Speakers include: @luskinglab.bsky.social @renkawitzteam.bsky.social @pcusachs.bsky.social @gabrielneurohr.bsky.social @simonereber.bsky.social @zierlab.bsky.social @katemiro.bsky.social @sarawickstrom.bsky.social @rashmi-priya.bsky.social @stroudlab.bsky.social @becklab.bsky.social & many more!

Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...

Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!