Jan Lammerding - Lab

The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to west@neuro.duke.edu.

…and it provides a better understanding of the normal function of lamins, particular in skeletal and cardiac muscle cells. The work was led by the amazing Jacob Odell and supported by the National Institutes of Health (NIH), National Science Foundation (NSF), and Leducq Foundation.
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This effect is due to the unique rod domain of lamin A/C, and does not require the lamin Ig-fold or tail, nor unique binding partners. This work has direct implications for our understanding of how mutations in the LMNA gene cause muscular dystrophy and heart disease…

What allows lamins A and C to confer much stronger mechanical stability to the nuclei than lamin B? We show that even though all lamins can protect the nucleus from small cell intrinsic forces, only lamin A/C protect the nucleus from large deformations: www.biorxiv.org/content/10.1...
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The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

Join us for the first Mechanobiology of the Nucleus conference supported by @faseborg.bsky.social. Co-organized with @lammerdinglab.bsky.social, @katemiro.bsky.social and Verena Ruprecht, the amazing program is here:
events.faseb.org/event/Mechan...
Opportunities for talks! Abstracts by Aug. 31st.

cureEDMD cureEDMD is a patient and family-led, scientist-supported foundation to advance research into a treatment or cure for Emery-Dreifuss Muscular Dystrophy (EDMD)

If you know anyone with Emery-Dreifuss Muscular Dystrophy (#EDMD) or want to support research on this disease, a patient family we have been working with for many years has started a new foundation, cureEDMD, to raise awareness for this devastating disease: www.cureedmd.org
Please share widely!

Sorry for misspelling Verena’s last name. It should of course be Verena Ruprecht!

Excited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way!
#notforprofit

Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!

I'm a current Harvard graduate student and I found out today that I had my NSF GRFP terminated without notification. I was awarded this individual research fellowship before even choosing Harvard as my graduate school

The entire nation should protesting this utterly unwarranted, unprecedented, & probably illegal on-going attack on a university. It's right out of the authoritarian playbook. It's an assault on possibility free speech, free thought, & dissent.
Fascism is coming small step by small step, not at once.

"We need the whole country to appreciate that by investing in university research and educating the next generation of explorers and innovators, the country has reaped, and will continue to reap, tremendous rewards in new cures, treatments, and inventions, and in new industries, companies, and jobs"

Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression - npj Biological Physics and Mechanics npj Biological Physics and Mechanics - Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression

How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and what role does #mechanobiology play here? Learn more in our recent review by fantastic Sarah Henretta, now out in NPJ - Biological Physics and Mechanics, open access: doi.org/10.1038/s443...

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

If biotech wants to continue to recruit highly talented, energetic, and creative PhDs they need to help us to advocate for stable funding for young scientists in academia to prevent a brain drain and loss of scientific innovation.
We discuss this on this week's Night Science Podcast with David Baker

Celebrating 140 Years of Women in Engineering at Cornell @cornellengineering.bsky.social and their amazing achievements.
Hosted by @mchvdm.bsky.social and Lara Estroff, trailblazers in their own right.

Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...

Our first 2025 paper!
We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer.
Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏
www.nature.com/articles/s41...

Cartoon showing key mechanotransduction signalling pathways to the nucleus. Mechanosensitive ion channels at the plasma and nuclear membranes allow Ca2+ entry into the cytoplasm and nucleus, activating downstream signalling pathways. NE stretching opens NPCs, facilitating entry of transcription factors (TF) and transcriptional coregulators (TCR) that alter gene expression. Additionally, NE stretching activates Ca2+ channels in the ER, promoting Ca2+ entry into the nucleus. Stretch-induced activation of cytosolic phospholipase A2 (cPLA2) further drives the arachidonic acid (AA) pathway, leading to gene expression changes.

In their Review, Julien Morival, Anna Hazelwood and Jan Lammerding @lammerdinglab.bsky.social discuss new insights and technological advances in understanding nuclear mechanotransduction.
journals.biologists.com/jcs/article/...

Thank you!

Feeling the force from within – new tools and insights into nuclear mechanotransduction Summary: This Review discusses new insights and technological advances in understanding how the nucleus contributes to the ability of the cell to translate mechanical stimuli into transcriptional resp...

Interested in nuclear mechanobiology, and how advanced genomic tools can shed light on how the cell nucleus might sense mechanical forces? Read our latest review by excellent Julien Morival and Anna Hazelwood, now published @jcellsci.bsky.social:
journals.biologists.com/jcs/article-...

Second, women make terrific leaders. They tend to be organized and prepared. They also tend to be more empathic as they have often experienced more challenges and setbacks than men in similar positions. They tend to be more courageous, particularly when the stakes are high.

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Francis Collins with a Stand Up for Science organizer.

3 women pose with Bill Nye.

2 Stand Up for Science organizers with a speaker named Connor.

Stand Up for Science organizer with Dr. Atul Gawande.

What a surreal experience. #standupforscience2025 is the honor of my lifetime. I am just speechless. So grateful to the hundreds of volunteers, thousands of attendees, and countless inspirational speakers across rallies. My heart is full. @standupforscience.bsky.social 1/2

Extending my grant update this morning. Here are data limited to new and competitive renewal applications.

The Pause is dead, Long live the Pause...

Great opportunity: applications are open for the Weill Institute Emerging Scholars Symposium @Cornell! Senior PhD students and postdocs interested in networking & presenting their work in cell & molecular biology should apply by Apr 14. wicmb.cornell.edu/emerging-schol… Please repost!

@aamctoday.bsky.social @aaup.bsky.social @asm.org

Many grad programs are pausing and reducing admissions in response to NIH funding pauses and pending EO’s on indirect cost reductions. These workforce reductions have the potential to imminently and irreversibly harm research labs & grad programs

Thank you @nplb.bsky.social for speaking out in defense of patients, the US economy and our citizenship. Encouraged to see biopharma and investors among patients, health care providers, scientists and policy makers.

www.nopatientleftbehind.org/defending-th...

We have to fight now for research that we know benefits all of humanity, we have to stand up for our colleagues at the NIH, we can’t lie down and take it, we stand against this madness #standupforscience2025

Executive wants to frame the NIH indirects cut as $4B in savings.

But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.

1. Today the NIH director issued a new directive slashing overhead rates to 15%.

I want to provide some context on what that means and why it matters.

grants.nih.gov/grants/guide...