Jan Lammerding - Lab

Attending the ASCB/EMBO Cell Bio #cellbio2025 in Philadelphia? Check out the posters from our lab on nuclear mechanobiology, lamins, and mechanotransduction today and on Tuesday. I will be there too and look forward to catching up!

Good eye! Yes, it’s 2um wide and 5um tall, very similar to some of the smaller interstitial spaces in vivo.

Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social

Thanks to @katemiro.bsky.social , Megan King, Verena Ruprecht & @lammerdinglab.bsky.social for organising the very first meeting on the “Mechanobiology of the Nucleus” #MBNSRC @faseborg.bsky.social and for the invitation to present our discoveries. The conference was fantastic!

Thanks so much! We were delighted to have you as a speaker! Looking forward to the next one in two years!

Congratulations!!

It’s been a pleasure working with @apdaria.bsky.social, Julie Heffler, and the Prosser Lab on this study, supported by the Leducq Foundation and the National Institutes of Health (NIH). This research is one step to get us closer to an effective treatment for cardiac #laminopathies and #LMNA-DCM.

Registration is still open, and abstracts for posters are still accepted (email me for info or questions)!

Congratulations!!

A big thank you for the GENEROUS support, although general support is good too! :)

A big Thank You to the general support from the NIH-NHLBI, the Leducq Foundation, the American Heart Association @ahascience.bsky.social, a Fleming Research Fellowship, and the Mills family.

Expression of a dominant negative nesprin domain, DN KASH, which disrupts the LINC complex, reduces forces on the nucleus, reduces nuclear envelope rupture, and restores expression of many dysregulated genes. DN KASH expression also rescues cardiac function and extends survival by >1 year.

Detailed transcriptomic analyses indicate that a subset of cardiomyocytes drives disease progression by expression of genes associated with sterile inflammation, likely downstream of nuclear envelope rupture and activation of cytosolic DNA sensors, independent of cGAS/STING.

How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.

A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites Lamins form a dense meshwork at the inner surface of the inner nuclear membrane (INM), where they interact with other nuclear envelope proteins such as emerin. Emerin is an integral membrane protein t...

Odell, J et al. (@lammerdinglab.bsky.social lab) A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites. bioRxiv posted 2 September 2025 doi:10.1101/2025.09.01.673543. www.biorxiv.org/content/10.1...

Thanks so much for highlighting our work!

I should point out that the conference is held in Melbourne, Florida, not Australia!

Speakers include: @luskinglab.bsky.social @renkawitzteam.bsky.social @pcusachs.bsky.social @gabrielneurohr.bsky.social @simonereber.bsky.social @zierlab.bsky.social @katemiro.bsky.social @sarawickstrom.bsky.social @rashmi-priya.bsky.social @stroudlab.bsky.social @becklab.bsky.social & many more!

Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...

Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!

FOMO no more: NOMO and Calmin extend #mechanobiology to the ER. Julie Heffler and Jan Lammerding @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) & @hennelab.bsky.social (doi.org/10.1016/j.ce...), in Spotlight: rupress.org/jcb/article/...

Interested in #mechanobiology of the cell nucleus? The submission deadline for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus is August 31, 2025. Submit your abstract to be considered for a platform presentation.
#MBNSRC

events.faseb.org/event/Mechan...

Last chance to register and submit an abstract to be considered for a platform presentation. If you are interested in nuclear #mechano Ta

Heffler and @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) and @hennelab.bsky.social (doi.org/10.1016/j.ce...) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum. rupress.org/jcb/article/...

You are very welcome. It’s been a pleasure reading and highlighting your beautiful work and the evidence you present for how ER tubules are anchored to actin filaments and focal adhesions!

Please submit your abstracts by August 31st to be considered for a platform presentation! We look forward to an exciting and stimulating meeting! Please share!

Happy #FluorescenceFriday! Our #CellLineOfTheWeek is MLC-2a - illuminating sarcomeric thick filaments! 💪🧫

Our high-quality stem cell lines & plasmids are available for just the cost of shipping to reduce the barriers to discovery.

📦 Dist. by @coriellinstitute.bsky.social & @addgene.bsky.social.

The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to west@neuro.duke.edu.

…and it provides a better understanding of the normal function of lamins, particular in skeletal and cardiac muscle cells. The work was led by the amazing Jacob Odell and supported by the National Institutes of Health (NIH), National Science Foundation (NSF), and Leducq Foundation.
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This effect is due to the unique rod domain of lamin A/C, and does not require the lamin Ig-fold or tail, nor unique binding partners. This work has direct implications for our understanding of how mutations in the LMNA gene cause muscular dystrophy and heart disease…