Elvira Forte

Fibroblast-Specific Loss of TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart | Circulation BACKGROUND: In patients surviving myocardial infarction, adipose tissue infiltration within the scar is a common pathological finding and has been suggested to contribute to dysfunction and arrhythmog...

Very interesting paper from the Frangogiannis’s lab — #Fibroblast -Specific Loss of #TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted #Heart (and cardiac rupture) www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @einsteinmededu.bsky.social

Cancelling mRNA studies is the highest irresponsibility The rest of the world is not following the US government’s dangerous path, and will stick with the technology that helped the world out of the COVID-19 pandemic.

A technology that played a key part in saving millions of lives during the pandemic should be celebrated. Yet in the US, research into mRNA vaccines is being cut. While sadly not unexpected, it’s irresponsible as we argue in our editorial this week 🧪

www.nature.com/articles/d41...

🚨 New preprint from the #EricAndWendySchmidtCenter! 🚨
"MORPH Predicts the Single-Cell Outcome of Genetic Perturbations Across Conditions and Data Modalities"

www.biorxiv.org/content/10.1...

@broadinstitute.org #SingleCell #PerturbSeq #OpticalPooledScreen #AIinBiology #ScienceNews #CompBio

#FOGBoston festivalofgenomics.com/boston

This tiny device can shrink dangerous blood clots. It’s called the ‘milli-spinner’ and its invention was partly an accident…

World Oceans Day is this weekend. 🌊⚒️🧪

Can you go from protein sequence to a generated image of protein localization? New work from the Uhler lab says yes, and it is generalizable to unseen proteins and more than one cell type. I'm excited for work moving us toward virtual cell models.

YouTube video by Amanpour and Company Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏

youtu.be/8YhJM6zxYDw?...

PUPS - prediction of unseen proteins' subcellular localization - uses machine learning models to predict the localization of unseen proteins in unseen cell lines from sequence and cellular images.

www.nature.com/articles/s41...

YouTube video by Altitude Films OCEAN WITH DAVID ATTENBOROUGH | BOTTOM TRAWLING OFFICIAL CLIP | IN CINEMAS NOW | Altitude Films

EXPOSED: Never seen before footage reveals the catastrophic impacts caused by bottom trawling ❌

@oceanauk.bsky.social

www.youtube.com/watch?v=IzG9...

a yellow sign that says we 're hiring ALT: a yellow sign that says we 're hiring

Exciting news...Nature Methods is hiring a new editor! This exciting and dynamic role will be shared with the Nature Research Cross-Journal Editorial Team.

Apply here by June 1!
springernature.wd3.myworkdayjobs.com/SpringerNatu...

Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis - Nature Inhibition of a cardiac stroma-enriched mechanosensor, SRC—in concert with suppression of the TGFβ pathway—potentiates the reversal of fibroblast activation and alleviates contractile dysfunction in f...

Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis www.nature.com/articles/s41...

David Liu receives Breakthrough Prize in Life Sciences Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine.

David Liu receives Breakthrough Prize in Life Sciences.
Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine. www.broadinstitute.org/news/david-l...

The cover of Cell showing an image of a human heart and coronary arteries during development

Thrilled that our work on coronary dominance made the cover of @cellpress.bsky.social! This beautiful image is thanks to the incredible work of @pamrc.bsky.social! 😍

#CardioSky

www.cell.com/cell/fulltex...

75th Annual Meeting of the British Microcirculation and Vascular Biology Society University of Surrey, GuildfordThursday 3rd and Friday 4th July 2025 Registration Abstract Submission Contact Organising Committee Click below to download flyer BMVBS MembershipMembers (before…

🌟 Few hours left to submit your abstract for the Annual Meeting of the Society (3-4 July 2025, University of Surrey, Guildford). Great programme, even better people...and a murder mystery at dinner! www.microcirculation.org.uk/75th-annual-... 🌟

This week, I have the privilege of interviewing Dr. Elisabeth Bik (@elisabethbik.bsky.social) in a special two-part series. We discuss her rich professional experience and path to data sleuthing. This is part I .https://www.podbean.com/eas/pb-9p4ye-1865e2f #science #research #integrity #data

An open letter to graduate students and other procrastinators: it’s time to write Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write

So many good suggestions in this insightful piece by Dennis J Hazelett. “The only way to give structure to your thoughts is to write them. Writing.Is.Thinking” @naturebiotech.bsky.social

www.nature.com/articles/s41...

Anna Greka: Molecular Sleuthing for Rare Diseases Listen now | Finding the Mechanisms and the Basis for Potential Cures

Research support for rare diseases, which cumulatively affect ~30 million Americans, is primarily derived from NIH.
Such work is exemplified by Prof Anna Greka @broadinstitute.org in a new Ground Truths podcast.
Open-access, w/ transcript, video, no ads
erictopol.substack.com/p/anna-greka...

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

I heard about this interesting story a couple of years ago at an AHA meeting @ahascience.bsky.social. It's great to see it published @CellSystems. Congratulations @shovalmiyara.bsky.social‬, @eldadtzahor.bsky.social
@urialonlab.bsky.social et al!

Single-molecule live-cell RNA imaging with CRISPR–Csm - Nature Biotechnology Single-molecule live-cell fluorescence in situ hybridization uses an RNA-targeting CRISPR–Csm complex to image and track endogenous RNAs.

Visualizing RNA in live cells using CRISPR
nature.com/articles/s41...

Tissue clocks derived from histological signatures of biological aging enable tissue-specific aging predictions from blood - Scientific editing and writing experts - Life Science Editors Scientific editing and writing experts for manuscripts and grants

We started writing/posting Snippets a week ago, and our third one is up now, about tissue clocks and aging, written by Katrina Woolcock with a great image by Gloria Fuentes, both colleagues at Life Science Editors. Have a look!

www.lifescienceeditors.com/2025/02/13/t...

Checkout "Snippets" - the brainchild of our editor extraordinaire @sfmatheson.bsky.social www.lifescienceeditors.com/snippets/

“To strive, to seek, to find, and not to yield”, beautiful poem and very insightful summary of our conversation. Thank you @ahmedgibrahim.bsky.social !

Doing a little catch-up posting with the Let's Get Coffee series. Today I reflect on my chat with @elviraforte.bsky.social and her thought-provoking question! www.podbean.com/eas/pb-r9pgp...

Novel Artificial Intelligence Approaches to Advance Cardiovascular and Cerebrovascular/Brain Health Research funding opportunity focused on novel AI approaches to advance cardiovascular and cerebrovascular/brain health

A total of $12 million in grant funding is available to fund 3 investigators/investigative teams proposing novel uses of Artificial Intelligence to revolutionize cardiovascular and cerebrovascular/brain health and health care delivery.

Learn more: professional.heart.org/en/research-...

Integrating representation learning, permutation, and optimization to detect lineage-related gene expression patterns - Nature Communications Recent barcoding technologies allow the reconstruction of a cell’s lineage tree while capturing paired transcriptomic data. Here, the authors present a statistical method to automatically detect gene ...

#Schmidt_Center publication: Hannah Schlueter and Caroline Uhler present a method to automatically detect #gene-expression patterns related to #lineage progression from paired #single-cell data, across different biological systems: broad.io/PORCELAN @naturecomms.bsky.social @broadinstitute.org

Eric and Wendy Schmidt Center | PRINT: A Milestone Technology for Understanding Gene Regulation A novel computational method provides valuable insights into DNA-protein interactions and cis-regulatory element dynamics.

www.ericandwendyschmidtcenter.org/updates/prin...

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

Join us for an exciting two-day symposium on #BiomedicalSciences and #AI, Apr 30th/May 1st, on #MIT Campus, organized by the Eric and Wendy Schmidt Center at @broadinstitute.org. Registration is free and abstract submission is open until January 31st www.ericandwendyschmidtcenter.org/symposiums/e...