Niladri Sinha

Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇

Thanks Kate!

If you are a motivated and curious scientist eager to drive independent projects within a collaborative environment, please do not hesitate to reach out at niladri.sinha@biochem.utah.edu. Kindly re-post this opportunity amongst your professional networks.

This is a unique opportunity to lead exciting projects and play an active role in shaping the lab culture, with a chance to apply a multidisciplinary toolkit (biochemistry, proteomics, genetics, and structural biology) to address exciting questions in translational control.

We have an opening for a Postdoctoral Fellow to join us in exploring fundamental questions at the interface of protein synthesis defects and stress-responsive signaling pathways. utah.peopleadmin.com/postings/187... #RNAsky

Thanks Junjie!

Thanks Michael!

Thanks Kamena!

Thanks Leo!

Likewise - thanks Brenda!

Thanks Charles!

Thanks Daniel!

Thanks Andi!

Thanks Judi!

Thanks Heather!

Thanks Ahmad!

It is an honor to return to the institution where I began my scientific journey. As I embark on establishing my lab, I approach this opportunity with excitement and humility. My goal is to train the next generation of scientists, paying forward the mentorship and support that shaped my career.

I take this opportunity to thank my postdoc and PhD advisors, Rachel Green and Brenda Bass @bbass.bsky.social who took great care to train me well, to my funding agencies NIGMS and @jcchildsfund.bsky.social for supporting my work, and to my family and close friends for their unconditional support.

The lab will employ multidisciplinary approaches to study cellular responses to translation #stress and #proteotoxicity. We seek to identify quality control and signaling pathways triggered by ribotoxic stress and develop therapeutic strategies to target these pathways in #cancer and #aging cells.

Join — The Sinha Lab We welcome curiosity-driven individuals excited to make foundational discoveries aimed at understanding and combating defects in translational control and proteostasis in a dynamic, collaborative, and...

We are hiring at all levels, so please help spread the word! #RNAsky #ribosomes #signaling #translation sinha.biochem.utah.edu/join

The Sinha Lab The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.

I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu

Portrait of RNA biologist Rachel Green at John Hopkins University.

“What a [sunburned] cell is trying to do is make decisions about whether to live or die based on how damaged the DNA is… but amazingly, it’s the RNA that signals that. That’s the remarkable observation.” — Rachel Green, biologist at Johns Hopkins University.
www.quantamagazine.org/rna-is-the-c...

We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇

Cellular responses to RNA damage RNA plays a central role in protein biosynthesis and performs diverse regulatory and catalytic functions, making it essential for all processes of life. Like DNA, RNA is constantly subjected to damage...

Happy to share our review on the cellular responses to RNA damage 🥂

Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social

www.cell.com/cell/fulltex...

Latest work from our next door neighbors! #RNAsky #RNAbiology

The life of each of us began when a sperm and an egg came together. But what happens at a molecular level?

Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)

www.cell.com/cell/fulltex...

Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...

Really excited to see this out! Congrats Simon, Anna, and team! 👏

m6A sites in the coding region trigger translation-dependent mRNA decay Zhou et al. discovered a specific role of adenosine modifications in the coding region of mRNAs. These chemical alterations slow down the movement of the ribosome during translation and trigger degrad...

m6A sites in the coding region trigger translation-dependent mRNA decay: Molecular Cell www.cell.com/molecular-ce...

Hot off the press: new review @AnnualReviews discusses recent time-resolved cryo-EM studies visualizing how ribosome moves and interacts with translation factors to achieve efficient and accurate translation.
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9