MILO Lab

Serotonergic neuron-glioma interactions drive high-grade glioma pathophysiology High-grade gliomas are lethal brain cancers that are powerfully regulated by glutamatergic neurons through activity-dependent paracrine factors and functional neuron-to-glioma synapses. Here, we repor...

www.biorxiv.org/content/10.6...

Very proud and truly honored to have taken part in this year’s SNO in Hawaii. Inspiring science, outstanding discussions, and my incredible lab pushing the boundaries @milolab.bsky.social Grateful for the beautiful setting that made this meeting unforgettable #SNO2025 #KeynoteSpeaker #NeuroOncology

Amazing Keynote talk by @heilandhenrik.bsky.social on "Translational Data Integration and Technological Developments in Neuro-Oncology" at the ongoing #SNO2025 in Hawaii.🧠

If you are at #SNO2025 be sure to check @milolab.bsky.social talks and posters including a keynote talk by @heilandhenrik.bsky.social #Hawaii🏖️🌊 #glioblastoma

✨ Early holiday vibes from the microscope! ✨
Live calcium imaging of glioblastoma cells at full confluence — bursting with spontaneous activity and glowing with waves of intracellular signaling. You can even spot a few cells dividing amidst the flicker.
#CalciumImaging #Glioblastoma

Just wrapped up an incredible few days in Prague for the @eanoassociation.bsky.social meeting! Truly inspiring sessions, great discussions, and exciting new collaborations. The MILO Lab shined with engaging talks and eye-catching posters! Ready to keep pushing the boundaries of science together!

A cup with the President - Episode 33: Prof. Dr. Oliver Schnell FAU-Präsident Prof. Dr. Joachim Hornegger besucht in jedem Semester Professorinnen und Professoren in ihren Instituten. Dort möchte er mit ihnen ins Gespräch über ihre Forschung kommen…

Oliver Schnell untersucht Hirntumore in ihrer Entstehung. Mit seinen Erkenntnissen möchte der Direktor der neurochirurgischen Klinik des Uniklinikums Operationen besser und sicherer machen.

FAU-Präsdient @hornegger.bsky.social war zu Besuch: www.fau.de/2025/09/news...

Tumor-initiating genetics and therapy drive divergent molecular evolution in IDH-mutant gliomas Astrocytomas and oligodendrogliomas are slow-growing and treatment-sensitive IDH-mutant gliomas diagnosed at ages 30-50. Local tumor regrowth and treatment resistance is inevitable resulting in 3-10 y...

New preprint on longitudinal treatment response signatures in IDH-mutant glioma from the GLASS Consortium www.biorxiv.org/content/10.1...

Happy to share a short "tools of the trade" piece on our NeuroPathology Spatial Transcriptomic Analysis (NePSTA) tool. Now available @natrevcancer.nature.com www.nature.com/articles/s41...

🧠 June 8 is #WorldBrainTumorDay — raising awareness & understanding of brain tumors.
EANO supports progress in #NeuroOncology through research, education & collaboration.
🔗 Learn more: www.eano.eu
#btsm #BrainTumor #Oncology

Thank you for the opportunity to present our work at #DGNC2025 in Hannover.

A dynamic and multimodal framework to define microglial states - Nature Neuroscience Sankowski and Prinz propose a classification framework for microglia states that considers the contextual plasticity of microglia. Their multimodal classification aligns a robust terminology with biol...

A Perspective on a dynamic and multimodal framework to define microglial states from @rsankowski.bsky.social and Marco Prinz

www.nature.com/articles/s41...

We had an amazing lab retreat Spring 2025! Best team of the world!

The @milolab.bsky.social retreat was lit 🔥. I am grateful and lucky to be in this amazing group.
Great people, great science.
#glioblastoma #spatialtranscriptomics
#scRNA-seq

Grade = microenvironment under a microscope, so we looked to see what specific environments in the tumor were associated w/specific myeloid activities using 10X Visium data from @milolab.bsky.social .Our Scavenger Suppressive program was only in hypoxia. The Complement Suppressive? Everywhere else

Programs, origins and immunomodulatory functions of myeloid cells in glioma - Nature A study of myeloid cells in gliomas, a type of brain tumour, used a factor-based computational framework to reveal four immunomodulatory gene-expression programs that are expressed across myeloid cell...

Proud to share our @nature.com paper, co-led by Chadi El Farran & Charles Couturier under mentorship of Brad Bernstein where we develop a new framework to understand immunomodulatory myeloid cells in #glioma & lay a foundation to develop more effective immunotherapies. www.nature.com/articles/s41...

Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵
Open access link:
www.nature.com/articles/s41...

Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile | EMBO Molecular Medicine imageimageIn patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting mitochondrial respiration. Combination with the current standard of ...

1/5 Excited to share our latest paper published in EMBO Molecular Medicine!🎉 🎉 embopress.org/doi/full/10....
This collaborative work brings together Team1 BRIC_Bordeaux, @ahmadsharanek.bsky.social, Andreas Bikfalvi, Lucie Brisson, Thomas Mathivet and our GBmetabo Team with Audrey Burban

Ever wondered what makes brain tumors tick?
Excited by the breakthroughs in spatial transcriptomics and single-cell analysis? Follow @milolab.bsky.social account on Instagram: cutting-edge insights, updates, and engaging content!

www.instagram.com/the_milolab/...

Happy to share our recent investigation of the spatial architecture of benign and malignant peripheral nerve sheath tumors.
@10xGenomics

🚨Spoiler Alert: We identified APOD in neurofibroma regions as a novel biomarker in hybrid PNSTs

t.co/GmA9MLNKy1

GitHub - heilandd/NePSTA: NeuroPathology Spatial Transcriptomic Analysis NeuroPathology Spatial Transcriptomic Analysis. Contribute to heilandd/NePSTA development by creating an account on GitHub.

We developed NePSTAR a novel graph attention network to predict methylation based phenotypes from visium inputs.

github.com/heilandd/NeP...

Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics - Nature Cancer Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ...

Happy to share your latest collaboration with
@sahm_lab
leveraging spatial transcriptomics
@10xGenomics
for neuropathology diagnosis #DeepLearning
! 107 patients across 15 CNS tumors!

www.nature.com/articles/s43...

🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social

@svenjaktetzlaff.bsky.social

1/15

Amazing talk by
Henrik Heiland
on using #spatialtranscriptomics data to model glioblastoma evolution #SNO2024