MILO Lab

Tumor-initiating genetics and therapy drive divergent molecular evolution in IDH-mutant gliomas Astrocytomas and oligodendrogliomas are slow-growing and treatment-sensitive IDH-mutant gliomas diagnosed at ages 30-50. Local tumor regrowth and treatment resistance is inevitable resulting in 3-10 y...

New preprint on longitudinal treatment response signatures in IDH-mutant glioma from the GLASS Consortium www.biorxiv.org/content/10.1...

16.07.2025 18:36 — 👍 14    🔁 4    💬 1    📌 0

Happy to share a short "tools of the trade" piece on our NeuroPathology Spatial Transcriptomic Analysis (NePSTA) tool. Now available @natrevcancer.nature.com www.nature.com/articles/s41...

05.07.2025 09:49 — 👍 7    🔁 2    💬 1    📌 0

🧠 June 8 is #WorldBrainTumorDay — raising awareness & understanding of brain tumors.
EANO supports progress in #NeuroOncology through research, education & collaboration.
🔗 Learn more: www.eano.eu
#btsm #BrainTumor #Oncology

08.06.2025 09:44 — 👍 11    🔁 6    💬 0    📌 0

Thank you for the opportunity to present our work at #DGNC2025 in Hannover.

05.06.2025 18:56 — 👍 3    🔁 0    💬 0    📌 0

A dynamic and multimodal framework to define microglial states - Nature Neuroscience Sankowski and Prinz propose a classification framework for microglia states that considers the contextual plasticity of microglia. Their multimodal classification aligns a robust terminology with biol...

A Perspective on a dynamic and multimodal framework to define microglial states from @rsankowski.bsky.social and Marco Prinz

www.nature.com/articles/s41...

20.05.2025 16:36 — 👍 11    🔁 4    💬 0    📌 0

We had an amazing lab retreat Spring 2025! Best team of the world!

07.04.2025 18:56 — 👍 3    🔁 1    💬 0    📌 1

The @milolab.bsky.social retreat was lit 🔥. I am grateful and lucky to be in this amazing group.
Great people, great science.
#glioblastoma #spatialtranscriptomics
#scRNA-seq

07.04.2025 21:29 — 👍 2    🔁 1    💬 0    📌 0

Grade = microenvironment under a microscope, so we looked to see what specific environments in the tumor were associated w/specific myeloid activities using 10X Visium data from @milolab.bsky.social .Our Scavenger Suppressive program was only in hypoxia. The Complement Suppressive? Everywhere else

27.02.2025 04:04 — 👍 1    🔁 1    💬 1    📌 0

Programs, origins and immunomodulatory functions of myeloid cells in glioma - Nature A study of myeloid cells in gliomas, a type of brain tumour, used a factor-based computational framework to reveal four immunomodulatory gene-expression programs that are expressed across myeloid cell...

Proud to share our @nature.com paper, co-led by Chadi El Farran & Charles Couturier under mentorship of Brad Bernstein where we develop a new framework to understand immunomodulatory myeloid cells in #glioma & lay a foundation to develop more effective immunotherapies. www.nature.com/articles/s41...

27.02.2025 04:04 — 👍 26    🔁 9    💬 4    📌 2

Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵
Open access link:
www.nature.com/articles/s41...

19.02.2025 21:41 — 👍 75    🔁 23    💬 2    📌 0

Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile | EMBO Molecular Medicine imageimageIn patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting mitochondrial respiration. Combination with the current standard of ...

1/5 Excited to share our latest paper published in EMBO Molecular Medicine!🎉 🎉 embopress.org/doi/full/10....
This collaborative work brings together Team1 BRIC_Bordeaux, @ahmadsharanek.bsky.social, Andreas Bikfalvi, Lucie Brisson, Thomas Mathivet and our GBmetabo Team with Audrey Burban

04.02.2025 20:39 — 👍 12    🔁 3    💬 1    📌 1

Login • Instagram Welcome back to Instagram. Sign in to check out what your friends, family & interests have been capturing & sharing around the world.

Ever wondered what makes brain tumors tick?
Excited by the breakthroughs in spatial transcriptomics and single-cell analysis? Follow @milolab.bsky.social account on Instagram: cutting-edge insights, updates, and engaging content!

www.instagram.com/the_milolab/...

30.01.2025 19:22 — 👍 1    🔁 1    💬 0    📌 0

Happy to share our recent investigation of the spatial architecture of benign and malignant peripheral nerve sheath tumors.
@10xGenomics

🚨Spoiler Alert: We identified APOD in neurofibroma regions as a novel biomarker in hybrid PNSTs

t.co/GmA9MLNKy1

30.01.2025 19:19 — 👍 3    🔁 1    💬 0    📌 0

GitHub - heilandd/NePSTA: NeuroPathology Spatial Transcriptomic Analysis NeuroPathology Spatial Transcriptomic Analysis. Contribute to heilandd/NePSTA development by creating an account on GitHub.

We developed NePSTAR a novel graph attention network to predict methylation based phenotypes from visium inputs.

github.com/heilandd/NeP...

30.01.2025 15:28 — 👍 1    🔁 0    💬 0    📌 0

Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics - Nature Cancer Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ...

Happy to share your latest collaboration with
@sahm_lab
leveraging spatial transcriptomics
@10xGenomics
for neuropathology diagnosis #DeepLearning
! 107 patients across 15 CNS tumors!

www.nature.com/articles/s43...

30.01.2025 15:28 — 👍 5    🔁 3    💬 1    📌 1

🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social

@svenjaktetzlaff.bsky.social

1/15

06.12.2024 23:18 — 👍 48    🔁 16    💬 2    📌 8

Amazing talk by
Henrik Heiland
on using #spatialtranscriptomics data to model glioblastoma evolution #SNO2024

22.11.2024 22:14 — 👍 8    🔁 2    💬 0    📌 0