Our thoughts, impressions, and presentations of the "2nd EuroDepMap symposium" in Milan (Nov 2025) are online at
@febsletters.bsky.social.
febs.onlinelibrary.wiley.com/doi/10.1002/...
Our thoughts, impressions, and presentations of the "2nd EuroDepMap symposium" in Milan (Nov 2025) are online at
@febsletters.bsky.social.
febs.onlinelibrary.wiley.com/doi/10.1002/...
Insights from the 2nd EuroDepMap Symposium are now out in FEBS Letters.
Last November at Human Technopole researchers in cancer functional genomics and computational biology discussed challenges and future directions in mapping cancer vulnerabilities and building predictive frameworks.
Link ⬇️
𝗧𝘄𝗼 𝗶𝗻𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁 analyses, 𝗼𝗻𝗲 𝗰𝗼𝗻𝘃𝗲𝗿𝗴𝗶𝗻𝗴 𝘀𝘁𝗼𝗿𝘆: here is 𝗈𝗎𝗋 𝗇𝖾𝗐 𝗌𝗍𝗎𝖽𝗒, 𝗋𝖾𝗅𝖾𝖺𝗌𝖾𝖽 𝖺𝗅𝗈𝗇𝗀𝗌𝗂𝖽𝖾 𝖺𝗇 𝗂𝗇𝖽𝖾𝗉𝖾𝗇𝖽𝖾𝗇𝗍 𝗐𝗈𝗋𝗄 𝖿𝗋𝗈𝗆 𝗍𝗁𝖾 𝗖𝗶𝗿𝗶𝗲𝗹𝗹𝗼 𝗴𝗿𝗼𝘂𝗽 (𝗦𝗲𝘀𝗶𝗮 𝗲𝘁 𝗮𝗹.), 𝗐𝗁𝖾𝗋𝖾 𝖢𝖱𝖨𝖲𝖯𝖱 𝖽𝖾𝗉𝖾𝗇𝖽𝖾𝗇𝖼𝗒 𝗆𝖺𝗉𝗌 𝖺𝗋𝖾 𝗎𝗌𝖾𝖽 𝗍𝗈 𝗍𝖺𝖼𝗄𝗅𝖾 𝗍𝗁𝖾 𝗌𝖺𝗆𝖾 𝖼𝗁𝖺𝗅𝗅𝖾𝗇𝗀𝖾: 𝗆𝖺𝗄𝗂𝗇𝗀 𝗌𝖾𝗇𝗌𝖾 𝗈𝖿 𝖼𝖺𝗇𝖼𝖾𝗋 𝘷𝘢𝘳𝘪𝘢𝘯𝘵𝘴 𝘰𝘧 𝘶𝘯𝘬𝘯𝘰𝘸𝘯 𝘴𝘪𝘨𝘯𝘪𝘧𝘪𝘤𝘢𝘯𝘤𝘦 using DepMap data. Links 👇
26.01.2026 17:22 — 👍 2 🔁 1 💬 1 📌 0
Festive vibes in Iorio Lab today: we spiced up the weekly lab meeting with a Secret Santa. Great company, fun gifts and a brief break from pipettes and plots!
09.12.2025 17:22 — 👍 6 🔁 1 💬 0 📌 0
@eurocancerdepmap.bsky.social, hosted by Francesco (alongside Pedro Beltrao from ETH Zurich, and Evangelia Petsalaki and Isidro Cortés-Ciriano from EMBL-EBI) at @humantechnopole.bsky.social, has concluded. Great speakers delivered breakthroughs that advance #cancer genomics across #Europe! 🏛️🧬
24.11.2025 10:53 — 👍 7 🔁 0 💬 0 📌 0
Last but not least, we are thrilled to have representatives from academia, industry, foundations and publishers to share with us their take during the roundtable discussion on Bridging Sectors for Translational Impact!
20.11.2025 16:50 — 👍 7 🔁 4 💬 0 📌 1
Evangelia Petsalaki presenting at the 2nd European Cancer Dependency Map Symposium
And we finish this session with @epetsalaki.bsky.social showing the potential of using CRISPR data to study context specific signalling and drug responses
20.11.2025 16:18 — 👍 12 🔁 5 💬 0 📌 0
The last session starts with Lodewyk Wessels from @nkinl.bsky.social sharing the work on perturbation response models!
20.11.2025 15:56 — 👍 6 🔁 4 💬 0 📌 0
Colm Ryan presenting at the 2nd European Cancer Dependency Map Symposium
@colmr.bsky.social takes the stage to share the work of his group that aims to understand and predict synthetic lethality between paralogs in cancer
20.11.2025 14:52 — 👍 9 🔁 3 💬 0 📌 0
We are back, starting the afternoon session with a joint talk by Debora Sesia/ @ciriellolab.bsky.social and @aurorasavino.bsky.social / @ioriolab.bsky.social showing their work on the functional assessment of Variants of Unknown Significance through cancer dependency map data analysis
20.11.2025 13:56 — 👍 9 🔁 4 💬 0 📌 0
The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social
20.11.2025 08:58 — 👍 9 🔁 7 💬 0 📌 0
We start with Carmen Herranz-Ors from @sangerinstitute.bsky.social giving us an overview of the impressive work done to generate Tumour Organoid Biobank and develop a 3D Dependency Map @eurocancerdepmap.bsky.social
20.11.2025 09:26 — 👍 8 🔁 4 💬 0 📌 2
Now @alejandrapcelab.bsky.social is taking us through the multidimensional map of early adaptation to treatment and how targeting cell plasticity can prevent childhood cancer relapse @eurocancerdepmap.bsky.social
20.11.2025 09:39 — 👍 9 🔁 5 💬 0 📌 0
First session of the @eurocancerdepmap.bsky.social symposium and so much fantastic work presented already! #CancerResearch #TranslationalScience #plasticity
20.11.2025 09:58 — 👍 13 🔁 5 💬 2 📌 0
Roland Rad gives the final talk of the second session of the 2nd European Cancer Dependency Map Symposium
To wrap up the second session, Roland Rad from the Institute of Molecular Oncology and Functional Genomics is sharing their work on mapping genetic interactions in cancer evolution and therapy @eurocancerdepmap.bsky.social
20.11.2025 11:46 — 👍 9 🔁 3 💬 0 📌 0
Talk by Chris Lord at the 2nd European Cancer Dependency Map Symposium
We continue with the talk from @icrlordlab.bsky.social focusing on the complexity of synthetic lethality in cancer and how we can move forward in exploiting it @eurocancerdepmap.bsky.social
20.11.2025 11:24 — 👍 8 🔁 3 💬 0 📌 1
Start of the second session of the 2nd EuroCancerDepMap symposium with a talk from Manuel Kaulich
The Synthetic Lethality and Innovations in CRISPR Screening session begins with @manuelkaulich.bsky.social telling us about exciting CRISPR libraries they have developed and how nuclear mRNA processing can mask the CRISPRko phenotypes @eurocancerdepmap.bsky.social
20.11.2025 10:50 — 👍 12 🔁 4 💬 0 📌 0
Now @alejandrapcelab.bsky.social is taking us through the multidimensional map of early adaptation to treatment and how targeting cell plasticity can prevent childhood cancer relapse @eurocancerdepmap.bsky.social
20.11.2025 09:39 — 👍 9 🔁 5 💬 0 📌 0
We start with Carmen Herranz-Ors from @sangerinstitute.bsky.social giving us an overview of the impressive work done to generate Tumour Organoid Biobank and develop a 3D Dependency Map @eurocancerdepmap.bsky.social
20.11.2025 09:26 — 👍 8 🔁 4 💬 0 📌 2
The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social
20.11.2025 08:58 — 👍 9 🔁 7 💬 0 📌 0@traver.bsky.social @humantechnopole.bsky.social
19.11.2025 16:59 — 👍 1 🔁 0 💬 0 📌 0
Delighted to host Traver Hart (MD Anderson Cancer Center), who delivered an engaging seminar on synthetic lethality at #HumanTechnopole. He showed how bridging #CRISPR and predictive modeling can advance design and interpretation of genetic interaction screens and inform new therapeutic strategies.
19.11.2025 16:58 — 👍 7 🔁 3 💬 2 📌 0
Kudos to Nevenka Radic for winning the best poster award! Very well deserved 🎉
29.10.2025 13:38 — 👍 2 🔁 0 💬 0 📌 0
Francesco Iorio’s invited talk highlights how we integrate clinically relevant mutational profiles with CRISPR functional genomics data to uncover vulnerabilities associated with mutations currently considered non-actionable, expanding potential therapeutic opportunities.
29.10.2025 13:37 — 👍 1 🔁 0 💬 0 📌 0
Vanessa Spagnolo presents how we dissect cancer dependencies using CRISPR functional genomics, and how we are applying these approaches across multiple projects in our lab to identify new therapeutic vulnerabilities.
29.10.2025 13:34 — 👍 1 🔁 0 💬 0 📌 0
Nevenka Radic is showcasing our work charting the genetic dependencies of drug-resistant cancer cells. By identifying context-specific vulnerabilities, we aim to inform the rational design of combinatorial treatments to advancing precision oncology.
29.10.2025 13:33 — 👍 1 🔁 0 💬 0 📌 0@humantechnopole.bsky.social
29.10.2025 13:30 — 👍 0 🔁 0 💬 0 📌 0