The Tidgewell Research Lab

Veraguamide E, a Marine Cyanobacterial Depsipeptide Targeting σ2R/TMEM97: Chemical and Neurobiological Characterization The human sigma-2 receptor/transmembrane protein 97 (σ2R/TMEM97) has been identified as a promising target to modulate neuronal excitability in chronic pain and address the unmet need for nonopioid th...

Really excited about this paper going live this mornning!!

Lots of hard work by a great team and should be more to come

Veraguamide E, a Marine Cyanobacterial Depsipeptide Targeting σ2R/TMEM97: Chemical and Neurobiological Characterization Journal of Natural Products pubs.acs.org/doi/full/10....

Assistant or Associate Professor in Microbiology The Department of Biology in the College of Arts and Sciences at the University of Kentucky in Lexington, KY seeks to fill a tenure-eligible faculty position at the Assistant or Associate Professor le...

The Department of Biology at the University of Kentucky is hiring a Microbiologist (broadly defined). Microbial eco-evo folks, this is your sign to come work with us. Not in the search committee, but happy to answer questions.
ukjobs.uky.edu/postings/600...
#microbiology #ecology

FLyer listing title and location for a seminar within the Department of Pharmaceutical Sciences at the University of Kentucky. Includes an image of the graduate student presenter.

Fun to start the day off today with a departmental seminar by one of the grad students in the lab.

Back in New Hampshire for some fun at the GRC Bioactives and Natural Products!! Stoked for a week of science and walking in the woods and more science

So I was doing some account balancing today and just noticed the Sigma is adding a "Tarriff" Charge onto our most recent orders ... anyone else notice that? #chemsky

a cartoon says hey everybody an old man 's talking while bart simpson looks on ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

A short Bluetorial about my early days as the Director of the National Institute of General Medical Sciences (NIGMS) at NIH.

The importance of feeling responsibility and taking pride in doing the best job you can

Summary Table of the massive defunding of biomedical research in the United States
www.nytimes.com/interactive/...

Added alt

Lab earned a gold star today! Way to go team, keep up the hard work
@ukresearch.bsky.social

Here is the dirty secret no one is speaking out loud: Trump does not believe that bombing the hell out of Iran is going to send Iran back to the negotiation table, nor has anyone in his inner circle suggested to him that outcome.

He fully knows he has entered America into a war.

'This is not Constitutional': GOP congressman stands up to Trump on Iran strike U.S. Rep Thomas Massie (R-KY) declared Saturday evening that his party's leader, the president of the United States, made an unconstitutional move.Trump over the weekend announced his administration had dropped a "full payload of bombs" on Iran."We have completed our very successful attack on the th...

U.S. Rep Thomas Massie (R-KY) declared Saturday evening that his party's leader, the president of the United States, made an unconstitutional move.

Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump (Gift Article) Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.

New powerful article up in the New York Times on cancelled and delayed grants

www.nytimes.com/interactive/...

My new favorite one are www.nature.com/articles/s41... and bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

So Yoda1 is the compound that actives Piezo channels and Dooku1 blocks them!!

Piezo channels are ... wait for it ... Force channels
#maythe4thbewithyou

Group Photo Day!
@ukresearch.bsky.social

Research drives discovery at UK.

Funding from the NIH makes a difference. UK Acting Vice President for Research Ilhem Messaoudi explains how this funding impacts Kentuckians.

Learn more: www.research.uky.edu/news/researc...

Some important additional considerations about the need to comment of the implementation of schedule F.

First, several sources have indicated that Institute Director and Division Director positions would likely be converted but not Program Officers.

1/n

This is heartbreaking and terrifying

Really fun visit to @ucsantacruz.bsky.social for a seminar
Huge thanks to @drlaurasanchez.bsky.social for the invite
Tried my best to channel banana slugs and was rewarded with a couple along the walk in 😁

Waltz and staff used Gmail for government communications, officials say Trump’s national security adviser is trying to manage his way out of a crisis. But new revelations about his team’s operational security are piling up in the inbox.

Somehow you knew this was coming.

They will do anything to avoid responding meaningfully to FOIA requests.

See this chart for one stark example: NIH funding has dramatically slowed down.

Grant awards are down *$3 billion* so far, compared to same time period last year

I asked the White House to explain.

“This is not a researcher entitlement program,” said an official, defending their new approach.

Awesome visit to @utah.edu for a seminar in the Pharm Tox Department
Lots of great neuroscience focused chats and great group of faculty plus snuck out to see a bit of nature as well

Another fun international collaboration (that started via email) resulting in a publication out today!
Happy to be a small part of this awesome chemistry effort by the groups at Uni Bristol

All of the physics knowledge in the world and all of the paper published about NASA’s success and failures won’t save you if you fired the seamstress who knew the one weird trick to the stitches on a blanket or a parachute.

Not all knowledge is translated well by text. (2/)

Aqueous and Ethanol Extracts of Acacia sieberiana (Fabaceae) Stem Bark Reverse the Pain–Depression Dyad in Mice Through Modulation of Catecholamines, Proinflammatory Cytokines, and Oxidative Stress Rationale and Objective: The pain–depression dyad is highly prevalent and has reciprocal psychological and behavioral effects, leading to poor quality of life, increased disability, and challenging t...

New paper with my collaborator in Cameroon exploring the utility of traditionally used plants as therapeutics and for discovering new leads for development. Check it out!

onlinelibrary.wiley.com/doi/full/10....

One new post on Federal Register about meetings in late March early April and three more that should be posted by tomorrow ... at least review can return and hopefully that means we can have a sense of grant funding soon

Before grants are awarded, they have to be evaluated in meetings called study sections.

Before a study section can meet, it has to be listed in the federal registry for at least 15 days.

These are the new study section meetings listed in the federal registry this year.
2/

In Frankfort!
www.eventbrite.com/e/stand-up-f...

Better?

BREAKING:
The NIH summer internship program (SIP) has been officially cancelled, across all institutes.

It’s a sad loss for the brightest science students in America, for American science, and for future cures for diseases like cancer and Alzheimer’s. 🧪 1/