Leo Otsuki

🔬 Limb regeneration depends on regenerative signaling center cells — but how do these cells influence others to proliferate, migrate, or differentiate?
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !

Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! https://f.mtr.cool/jncxfqkuds

Thank you very much, Osvaldo!

Thank you! I cannot wait to get started.

Thank you, Yan!

Thanks, Çağrı!

Thank you, Yasin! You are always so kind. I wish you all the best in your new home too.

Thanks, Sanjay! I wish you also exciting next steps!

Thank you, Amro!

Thank you very much, Diana!

Thank you, Josh. Looking forward to crossing paths again!

Thanks very much, Neha!

Thank you, Filipa - you are always so kind! I'm looking forward.

Thank you, Osvaldo. You've always been an amazing source of support and encouragements. I can't wait to pop over and see you - I'm sure Aida and I can arrange something :)

Grateful and excited to launch the Otsuki Regeneration Group at the Hubrecht Institute!
🔗 www.hubrecht.eu/research-gro...

We study how tissues regenerate - and use those principles to build 3D tissues in vitro.

Full announcement: www.linkedin.com/in/leo-otsuk...

@hubrechtinstitute.bsky.social

🧬 Looking for a PhD position in molecular or developmental biology? 🔬

✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/

Thank you very much 😊🎉

Thank you, Aniek :)

I highly recommend signing up for this! I found it so informative and constructive. I owe a lot to Sumru and Mekayla, from answering my super-naive questions to advising on my proposal and setup last year. Thanks so much, you are treasures of the regeneration community!

Salamanders normally regenerate only the missing part of the arm after an injury - e.g. | Leo Otsuki Salamanders normally regenerate only the missing part of the arm after an injury - e.g. a wrist-level injury only regenerates a hand. But if they receive retinoic acid (RA), this control is overridden...

A (little bit) more info here: www.linkedin.com/feed/update/...

Retinoic acid breakdown is required for proximodistal positional identity during axolotl limb regeneration - Nature Communications How axolotl salamanders know what portion of the limb to regenerate remains a mystery. In this article, the authors show that precise retinoic acid degradation is critical for instructing…

Precise degradation of Retinoic acid (RA) determines which part of the limb a salamander regenerates. Congratulations to the team, expertly led by Tim Duerr in James Monaghan's group:

This raises exciting questions about the molecular and physical requirements for re-building each part of the limb.

Congratulations to all the authors @jamesmonaghan.bsky.social lab on a beautiful study!

Similar to whole-limb regeneration, nerves are essential for the digits to regenerate. Amazingly, the authors found that the second finger regenerates more accurately than the others (why?) - but apparently not due to the degree of nerve innervation or differences in classical limb patterning genes.

A Characterization of Axolotl Digit Regeneration: Conserved Mechanisms, Divergent Patterning, and a Critical Role for Hedgehog Signaling Axolotl digits offer an experimentally versatile model for studying complex tissue regeneration. Here, we provide a comprehensive morphological and molecular characterization of digit regeneration,…

Axolotls accurately regenerate their limbs but frequently make mistakes during finger regeneration, which surprises me given their apparently simple structure. This study, led by Jackson Griffiths from James Monaghan's lab, dives deep into this fascinating paradox. www.biorxiv.org/content/10.1....

We are really grateful and honored for this comment on our latest preprint! AND we share the spotlight with the Monaghan lab!
Thanks @woutermasselink.bsky.social and @dev-journal.bsky.social

Yes - dream team! Congratulations to all of you on this beautiful synergy 👏

Congratulations, Anna!!

We are hiring a new PhD student in #Bioinformatics and Organ #Regeneration using to join our team at the @hubrechtinstitute.bsky.social

If you are interested in how the heart regenerates and want to work in a dynamic and experienced team please apply here.

www.hubrecht.eu/job/phd-stud...

Thanks very much, Andras! Hope to cross paths soon. 😊

Thank you!