ANDCS

This is figure 1 from “Human biomass movement exceeds the biomass movement of all land animals combined.” It shows total biomass movement of land animals and birds.

Human biomass movement may be up to 40 times greater than that of all land animals combined, according to research in Nature Ecology & Evolution. A second Nature Communications paper finds that wild mammal biomass has more than halved since 1850. go.nature.com/4oID33i go.nature.com/3LhSD7n 🧪

Kaplan–Meier curves of the cumulative incidence of death from any cause, myocardial infarction, or heart failure (the composite primary end point).

In a meta-analysis of 17,801 patients with myocardial infarction and preserved LVEF (≥50%), beta-blockers did not reduce death, MI, or heart failure over a median 3.6 years of follow-up. Full results: nej.md/43U5Ppo

#AHA25

This is figure 1, which shows LbL NPs undergo dynamic reorganization on contact with physiological fluids.

Polymer-coated liposomes specifically target and deliver interleukin-12 to metastatic ovarian cancer, strongly sensitizing the tumours to combination therapy with immune checkpoint inhibitors, according to a paper in Nature Materials. go.nature.com/4ouOWds 🧪

Le lundi 17 novembre 2025 à 19h30, à l’ @ibensens.bsky.social, nous aurons le plaisir d’accueillir @lacombekarine.bsky.social
, professeure des universités - practicienne hospitalière (PUPH) en infectiologie à @sorbonne-universite.fr.

Inscrivez-vous ici : forms.gle/iguhqmQndjw1...

SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

A paper in Nature reports that mRNA vaccines targeting SARS-CoV-2, COVID-19, also sensitize tumours to immune checkpoint inhibitors. #medsky 🧪

Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.

Researchers in #ScienceTranslationalMedicine present a new method to generate stable, antigen-specific regulatory #Tcells in large quantities using the body’s own conventional T cell pool, and show the resulting cells can treat IBD and GvHD in mouse models. https://scim.ag/47dDYBm

Transcatheter Cardiovascular Therapeutics Original Article | Oct 27, 2025 | NEJM.org Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years Figure 1A. Death from Any Cause, Stroke, or Rehospitalization

In low-risk patients with severe aortic stenosis, transcatheter and surgical aortic-valve replacement had similar 7-year survival and valve durability outcomes, with no evidence of differences in composite end points. Full PARTNER 3 trial results: nej.md/4nieHfx  

#TCT2025 | @crfheart.bsky.social

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled in the faeces.

Nature research paper: Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion

go.nature.com/4nlQFQK

An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaques Mucosal delivery of a rhesus adenovirus–vectored H5N1 influenza vaccine confers protection against lethal challenge in cynomolgus macaques.

Vaccines for #H5N1 based on either mRNA or an adenovirus vector can shield macaques from the virus when delivered via an intramuscular prime and a mucosal boost regimen, according to new experiments in #ScienceTranslationalMedicine. https://scim.ag/47aS1HR

This ‘fundamental’ work substantially reveals how the cell’s glycocalyx (a dense layer of sugars and proteins on the cell surface) acts as a non-specific barrier, making it harder for viruses to interact with receptors.
buff.ly/YkpiWzD

New paper finally out on @natcomms.nature.com! Led by first author Maria Dramé with the collaboration of Francisco Garcia, @cbuch.bsky.social and @jytinevez.bsky.social at @pasteur.fr. Early mitochondrial signals in single human macrophages predict later Legionella replication. Link + details👇🧵

Le jeudi 23 octobre 2025 à 19h30, à l’ @ibensens.bsky.social , nous aurons le plaisir d’accueillir @thomasdavergne.bsky.social , enseignant-chercheur en sciences de la rééducation et de la réadaptation, à l'occasion du premier dîner double cursus de l'année !
Inscrivez-vous ici : urls.fr/RA1rrO

The astrocytic ensemble acts as a multiday trace to stabilize memory - Nature Emotional experience evokes signalling in astrocytes, which form an ensemble that is reinforced by secondary astrocytic state changes resulting from repeated experience, leading to memory stabilization.

Nature research paper: The astrocytic ensemble acts as a multiday trace to stabilize memory

go.nature.com/4hc7zQp

A replicating RNA vaccine protects cynomolgus macaques against lethal clade 2.3.4.4b influenza A H5N1 virus challenge LION-delivered replicating RNA vaccines are immunogenic and protect cynomolgus macaques against lethal influenza A (H5N1) virus challenge.

Replicating RNA vaccines based on older #H5N1 antigens can shield macaques from lethal infections with contemporary H5N1 strains, according to new work that hints current vaccine stockpiles can still offer cross-protection. #ScienceTranslationalMedicine https://scim.ag/3W1QdMn

Working model of the hypoxia-mediated longevity pathway.

Mild stresses on the body, like fasting or cold exposure, can delay ageing. But how?

A new Insight Article explores how oxygen-sensing neurons in C. elegans trigger body-wide stress signals that boost resilience and extend lifespan.
buff.ly/wJIQKfm

Unlocking data in Klebsiella lysogens to predict capsular type-specificity of phage depolymerases - Nature Communications Here, the authors exploit the genetic information encoded in Klebsiella prophages to model the interplay between bacteria, prophages, and their depolymerases, using a directed acyclic graph-model and a sequence clustering-based model.

Can we exploit past phage infection events (prophages) to decipher the specificity of phage receptor-binding proteins such as depolymerases?🔎 Happy to share our recent work at @natcomms.nature.com 🔽 #microsky #phagesky

www.nature.com/articles/s41...

Brain area linked to chronic pain discovered — offering hope for treatments The newfound ensemble of neurons could lead to therapies to treat persistent pain, which affects roughly one of five people globally.

The newfound ensemble of neurons could lead to therapies to treat persistent pain

go.nature.com/4gZHzrv

Hidden networks in the brain Dendritic nanotubes extend brain connectivity beyond synapses

I love these new layers of complexity that people are discovering in the brain! Dendrites of different neurons can connect via nanotubes, which transport calcium and cargo such as amyloid-beta www.science.org/doi/10.1126/...

Connecting chemical and protein sequence space to predict biocatalytic reactions - Nature A two-phase machine-learning-based tool making use of high-throughput experimentation is introduced to examine the connections between chemical and protein sequence space and predict productive biocatalytic reactions among substrate and enzyme pairs.

Nature research paper: Connecting chemical and protein sequence space to predict biocatalytic reactions

go.nature.com/4gUrL9t

Inside a thylakoid membrane

The molecular architecture of the thylakoid membrane in a vascular plant has been determined with single-molecule precision.
buff.ly/U9TzrOh

Protecting double Holliday junctions ensures crossing over during meiosis - Nature Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover products, which are required for accurate chromosome segregation during meiosis.

Nature research paper: Protecting double Holliday junctions ensures crossing over during meiosis

go.nature.com/46zKMcj

Un mécanisme clé de l’intégration du génome du VIH dans nos gènes élucidé L’infection par le VIH-1 repose sur l’intégration du génome viral dans certaines régions riches en gènes.

ResultatScientifique🔎| Le VIH profite d’une protéine humaine pour mieux s’installer dans notre ADN : une découverte qui ouvre de nouvelles pistes pour le combattre 🦠
✍️ Vincent Parissi
📕 @natmicrobiol.nature.com | buff.ly/Hqeu6kO

World's first AI-designed viruses a step towards AI-generated life Nature - Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.

Scientists have created the first ever viruses designed by AI, and they’re capable of hunting down and killing strains of E. coli

go.nature.com/4nA8E6p

Learning the natural history of human disease with generative transformers - Nature Delphi-2M forecasts a person’s future health, covering more than 1,000 diseases, provides insights into co-morbidity dynamics and generates synthetic data for the training of AI models that have never seen actual data.

Nature research paper: Learning the natural history of human disease with generative transformers

go.nature.com/4gzhLCo

Gross fetal pathology and histology of E12.5 DKO embryos and controls. All controls are KO for Vps13c and WT or heterozygous for Vps13a KO. Top: H&E stained longitudinal section of control (left) and DKO (right) fetuses processed for anti-CD34 immunohistochemistry. The DKO liver is much smaller (arrows) with reduced CD34 immunoreactivity (bottom) where the CD34 immunoreactivity on vascular endothelia (thick arrow, bottom left) and hematopoietic precursors (thin arrows) is shown in brown.

VPS13A & VPS13C are lipid transport proteins linked to #ChoreaAcanthocytosis & #ParkinsonsDisease. @pengxu.bsky.social @pdc-lab.bsky.social &co shows that mice lacking either protein are viable but absence of both results in defective #hematopoiesis & lethality @plosbiology.org 🧪 plos.io/46rTEAy

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Nature research paper: Fluctuating DNA methylation tracks cancer evolution at clinical scale

go.nature.com/4pzikAa

Inhibiting SLC38A2 lowers blood pressure in rodent models of hypertension Inhibition of Slc38a2 in vascular endothelial cells enhances NO-mediated vasodilation and reduces blood pressure.

The amino acid transporter SLC38A2 is linked to a higher risk of #hypertension and can be targeted to lower blood pressure, show new experiments in #ScienceTranslationalMedicine involving mice and an analysis of population cohorts in China and the U.K. Biobank. https://scim.ag/4mQ3Ji0

System architecture of quorum-sensing circuits. Top left: Quorum sensing in proteobacteria. A signal synthase (blue) produces a diffusible signal (black circles) that binds to a cytoplasmic signal receptor (light blue). When the signal reaches sufficient concentrations, it binds to and activates the receptor, which causes changes in transcription of target genes. Top right: The las and rhl systems of P. aeruginosa. The lasB gene is activated by both systems. The specific acyl-homoserine lactone signal molecule is pictured for each system. Bottom: Illustration of circuit architecture: reciprocal, hierarchical, and independent. Indicated below are the relative levels of lasB gene activation and sensitivity shown by Thomas and colleagues in experimental and modeling studies.

Many bacteria use #QuorumSensing to control genes based on population density. @jrchandler.bsky.social &co explore a @plosbiology.org study showing that in P. aeruginosa, 2 QS circuits activate each other, enhancing robustness & explaining redundancy 🧪 Paper: plos.io/3I7DhRG Primer: plos.io/4niSZZd

Supervised learning in DNA neural networks - Nature DNA molecules can be programmed to autonomously carry out supervised learning in vitro, with the system learning to perform pattern classification from molecular examples of inputs and desired responses.

Nature research paper: Supervised learning in DNA neural networks

go.nature.com/4mOb9lH

Ca2+ responses of PPC neurons during a short-term memory task. Left: The schematic illustrates the behavioral task designed to assess short-term memory in head-restrained mice. During the sample phase, black-and-white phase-reversing gratings moved either leftward or rightward (or downward or rightward) for 4 s on a screen in front of the mouse. After a 1.5- or 2-s delay, two laterally positioned lick ports were placed within reach of the mouse’s tongue. Correct licking at the corresponding lick port was rewarded with water, whereas incorrect licking resulted in a time-out as a punishment. Right: Color-coded trial-averaged ΔF/F traces of direction- and phase-selective neurons. Left Panel: neurons selective for rightward stimuli; Right Panel: neurons selective for leftward stimuli. ΔF/F values were normalized to the maximum ΔF/F and aligned based on each neuron’s time-to-peak response. Within each directional group, neurons are subdivided by phase selectivity based on GLM classification: those selective for the sample (S), delay (D), or both phases. The bottom panels display neurons that were jointly selective for both sample and delay phases (86 for rightward, 49 for leftward).

What are the neural mechanisms behind short-term #memory errors? This study shows that they are primarily linked to a drift in neural activity in posterior #ParietalCortex, highlighting a need for stable neural representations to support accurate memory performance @plosbiology.org 🧪 plos.io/4p85IzD