Sandra GL

UCL-led international research team wins $25m Cancer Grand Challenges funding Team REWIRE-CAN, led by Professor Bart Vanhaesebroeck of the UCL Cancer Institute, will receive up to $25m over approximately five years to take on the rewiring cancer cells challenge.

Congratulations to Prof Bart Vanhaesebroeck, Prof @christophertape.bsky.social & Team REWIRE-CAN on securing $25m in @cancergrand.bsky.social funding to take on the challenge of rewiring cancer cells.

#CancerGrandChallenges @uclmedsci.bsky.social

www.ucl.ac.uk/news/2026/ma...

🚨 New paper from our lab just published in Nature🚨

www.nature.com/articles/s41...

Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone

✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

Looking forward to working with new colleagues on a collaborative project in lung disease modelling and transcriptomics - please share! And email Jenny @jennydickens41.bsky.social, or me, with any questions. 😀

www.jobs.cam.ac.uk/job/52936/

Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer - Nature Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new perspectives for targeting lineage plasticity.

Nature research paper: Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer

go.nature.com/3ViRTAP

Recovery of human upper airway epithelium after smoking cessation is driven by a slow-cycling stem cell population and immune surveillance The upper airway epithelium in humans is maintained in homeostasis by a resident population of basal stem cells. In the presence of tobacco smoke these gain mutations that significantly increase their...

My main PhD project is now up on bioRxiv! If you’re interested in somatic evolution or machine learning for simulation-based inference, read on…

doi.org/10.1101/2025...
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Pre-Cancer Immunology The Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.

🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals.
✅ Wet & dry lab
✅ September 2025 enrolment
✅ UK tuition fees only

www.ucl.ac.uk/medical-scie...

Origins of common lung cancer that affects smokers discovered The ‘cell of origin’ of the second most common lung cancer and the way that it becomes dominant in the lung have been discovered, in a new study in mice and humans from researchers at UCL, the Wellcom...

The ‘cell of origin’ of the second most common lung cancer and how it becomes dominant in the lung have been discovered, in a new study led by Prof Sam Janes & Dr Sandra Gómez-López @uclmedsci.bsky.social, with @cambridgeuni.bsky.social & @sangerinstitute.bsky.social
www.ucl.ac.uk/news/2025/ma...

Our work describing the biological mechanisms driving the formation of a cancerized field in the airways is now out @science.org!
Huge team effort from @lungs4living.bsky.social and amazing collaborators to delineate the origin of precancerous lung disease 🫁
www.science.org/doi/full/10....