Serge McGraw

Now had a chance to read through this pre-print. Interesting and unexpected findings! Increasing DNMT1 expression leads to remodelling of the methylome in mouse ES cells including gains and losses 😮 🧵 1/2
#epigenetics

Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.

faculty-einstein.icims.com/jobs/17847/a...

If you're interested in DNA methylation dynamics, DNMT biology, disease modeling or epigenetic therapy, we hope this work sparks new ideas! 💡

Happy to discuss, critique, or collaborate! 9/9

Together, our findings reveal that DNMT1 overexpression alone is sufficient to generate cancer-like DNA methylation patterns and highlight candidate underlying mechanisms that warrant deeper exploration. 8/9

Conserved promoter hypermethylation between mESCs and human cancers showed signs of epigenetic priming and had sex-specific effects. 7/9

The same promoter regions hypermethylated by DNMT1 overexpression in mESCs are also hypermethylated in various human cancers — demonstrating the biological relevance and translational potential of this model. 6/9

DNMT1-targeted cancer therapies may have limits: some hypermethylation in mESCs resisted erasure following acute DNMT1 depletion. 5/9

We also found increased CpG‑to‑CpG methylation variability, a feature associated with epigenetic instability in cancer.

DNMT1 excess didn’t just shift DNA methylation levels — it disrupted DNA methylation precision. 4/9

Despite global hypomethylation, we observed focal hypermethylation at promoters and CpG islands — another hallmark of cancer methylomes.

These promoter DMRs were linked to pathways that align with the vast pathological potential of DNMT1 overexpression. 3/9

Despite DNMT1 being a maintenance methyltransferase, overexpression led to global, widespread hypomethylation in mESCs, mirroring a paradox seen in cancer. 2/9

🚨 New preprint alert!

DNMT1 is often elevated in cancer, but its direct impact on DNA methylation regulation has been hard to isolate in tumours full of confounding processes.

Using a clean genetic system in mESCs, we asked:
What does excess DNMT1 by itself do to the methylome?
Let’s dive in 🧵
1/9

Slowly killing science....

Scary number...

New work from the lab by @eli-elder.bsky.social !! Tread to follow shortly...

The recruitment campaign is on! We’re seeking outstanding MSc, PhD, and Postdoctoral candidates to join @cra-chusj.bsky.social . If you’re passionate about epigenetics, development, and neurodevelopment, consider exploring the opportunities available in my lab.
event.fourwaves.com/campagnerecr...

My Canadian university, Queen's, is offering TWENTY 4-year funded PhDs (40k CAD/yr) for a student of ANY citizenship who has been accepted at a top 100 US university but have had offer rescinded OR are reconsidering offer due to US policy.
Details found here👇

www.queensu.ca/grad-postdoc...

EMBO Gold Medal 2025 awarded to Tanmay Bharat and David Bikard – Press releases – EMBO Every year, EMBO awards the Gold Medal to group leaders in the early stages of their careers for their remarkable contributions to the life sciences in

EMBO is delighted to announce that this year the EMBO Gold Medal is awarded to Tanmay Bharat @tbharat-lab.bsky.social ‬ @mrclmb.bsky.social and David Bikard @dbikard.bsky.social @pasteur.fr for their remarkable contributions to the #LifeSciences.

www.embo.org/press-releas...
#award 🧪

Congrats to all winners! ...but especially to own, Michelle Robb, for the Best Poster Award at #DOHaDCanada2025! Michelle presented our recent advances on Early Embryonic Alcohol Exposure ! 🏆

Thank you, #DOHaDCanada2025, for organizing and for the invitation to present our work on Early Embryonic Prenatal Alcohol Exposure! #FASD #DOHaD #communautéFRQ

Congratulations to our co-president, Dr. Kristin Connor (@kconnor.bsky.social), for being awarded the Nick Hales Award by the International DOHaD Society. #DOHaD2025

Assistant Professor (Research), Department of Microbiology & Immunology, (C2-240724) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Come join us at @mcgill.ca as an assistant professor in virus-host interactions! Please share widely.

mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Paper Out👇🥳 thanks to ALL authors, Nakatani-san @tamas-schauer.bsky.social @palmrinmoy.bsky.social and bluesky-less

RIF1 regulates Replication Timing in mouse embryos & (suprising) findings disentangling effects on transcription and LADs...lots to think about 🙄👍🤔

👉 www.cell.com/developmenta...

Le cochon d’Inde : un modèle animal prometteur pour l’étude de l’embryon humain Sophie Petropoulos, chercheuse au CRCHUM, et son équipe révèlent pour la première fois que l’embryon préimplantatoire de cochon d’Inde est très similaire à l’embryon humain, ce qui ouvre la voie à une...

Sophie Petropoulos, chercheuse au CRCHUM, et son équipe révèlent pour la première fois que l’embryon préimplantatoire de cochon d’Inde est très similaire à l’embryon humain, ce qui ouvre la voie à une meilleure compréhension de l’infertilité et du développement humain précoce.

The guinea pig serves as an alternative model to study human preimplantation development - Nature Cell Biology Petropoulos and colleagues perform single-cell transcriptomics, spatial, functional and comparative analyses, and show that the guinea pig presents high similarity with early human embryogenesis.

🥂Congratulations to Petropoulos & co for their new Open Access study in our journal (@naturecellbiology.bsky.social): single-cell #transcriptomics, spatial, functional and comparative analyses show that the guinea pig presents high similarity with early human #embryogenesis.
bit.ly/3RaRwWY

The Lim Lab at the @crchum.bsky.social is recruiting PhD students or Postdoctoral Fellows to study the roles of 14-3-3zeta in #adipocytes or pancreatic #betacells.

Projects are supported by CIHR, NSERC, or Diabetes Canada.

Please share with people who might be interested!

Thanks!

I urge folks to sign this letter and share it with their university colleagues to get critical mass.

🔊Share widely!
Were looking for a Tier 2 CRC in Human Metabolic Disease!

Just posted but hurry as app deadline is May 15!

Got expertise in #obesity or #diabetes and are an emerging expert in your field?

Apply now!!!!

carleton.ca/deputyprovos...

Dear USA colleagues, paradoxically the environment is warmer for doing science north of the border.♥️

Just because you are unique doesn’t mean you are useful over a picture of a wooden headed axe.

This should save grant reviewers a lot of time on some of those proposals…..