Genomics Guy

How to Improve Your RNA-Seq Data with UMIs and ERCC RNA Scientists have developed two powerful tools for RNA sequencing (RNA-Seq) experiments to minimize bias and variability: unique molecular identifiers (UMIs) and ERCC RNA spike-ins. We’ll cover the basi...

What are #UMIs?

UMIs are short, random #nucleotide sequences added to individual #transcripts during library preparation and uniquely identify #cDNA. Learn how this powerful tool cleans up #RNASeq data for #GeneExpression analysis, resulting in improved #RNA-Seq data.

Read now: hubs.ly/Q03nSq1g0

With direct in sample sequencing (DISS), you can get targeted RNA, 3’ whole transcriptome, protein 🧬, and morphology 🔬 data all from the same cells. It’s multimodal, customizable, and fast. Watch the on-demand webinar to see how DISS on #AVITI24 can accelerate your research. ▶️ bit.ly/42XOGtN

Thrilled to announce I'm moving to Manchester to lead the Cancer Origins group! If you're interested in how mutations and exposures drive tumourigenesis — come join the adventure

Congratulations 👏🏼

‘You’re just not welcome’: researchers grapple with US plan to revoke Chinese student visas Scientists are eyeing their legal options in anticipation of new immigration actions.

Graduate students, postdocs and science lab leaders are reeling after an announcement last week that the US government will revoke visas for Chinese students — and they are contacting lawyers.

https://go.nature.com/4mLQ9fU

Last week at Oz Single Cell Sydney, we connected with brilliant minds in #singlecell and spatial biology. Thanks to all who joined our talk on "High Dimensional Biology Powered by #AVITI24". 📸 Big shoutout to the Australian scientific community—your energy was incredible! #OzSingleCell25

MIC-Drop-seq: Scalable single-cell phenotyping of mutant vertebrate embryos https://www.biorxiv.org/content/10.1101/2025.05.27.656468v1

Resolving the full set of human polymorphic inversions and other complex variants from ultra-long read data https://www.biorxiv.org/content/10.1101/2025.05.27.656315v1

The fantastic lineup for our latest webinar series, Unlocking the Epigenome: Precision Tools for Complex Diseases, includes: @chiaraherzog.bsky.social, @a-radzisheuskaya.bsky.social, @sankarinagarajan.bsky.social, @sebpreissl.bsky.social, @scherermich.bsky.social, and more! Check them out below!

The Fred Hutch lab has done this before. Interesting to see how different company's technologies compare in real world labs.

#singlecell #comparingtech

With one high profile litigation coming to an end in the Genomics sphere, another one begins:

Illumina v Element Biosciences.

Not read much into it yet. What are your thoughts? Similar feelings to that of the 10x v Nanostring(Bruker) saga?

For those in the UK BioPharma field, this may be of interest to you.

#biopharma #genomics #spatial

Unraveling Tyrosine-Kinase Inhibitor Resistance in NSCLC Cells via Same-cell Measurement of RNA, Protein, and Morphological Responses Non-small cell lung cancer (NSCLC) frequently develops resistance to tyrosine kinase inhibitors (TKIs), limiting the long-term success of targeted therapies. A deeper understanding of resistance mecha...

🌟 A new week, a new pre-print! See how we used AVITI24™ to study TKI resistance in NSCLC with single cell co-detection of RNA, protein, and morphology and identified CDK4/6 as a route of cell survival. 📖 Read the paper: bit.ly/3Fe3exr

Illumina unveils first-of-its-kind spatial transcriptomics technology

Another company enters the Spatial market. What impact will this have?

www.illumina.com/company/news...

With #AGBT nearly upon us there are a lot of rumors around #Roche and a new sequencer to rival #illumina. Is illumina's dominance slowly eroding? Would you still buy an illumina system if funds available?

Detecting Non-linear Dependence through Genome Wide Analysis https://www.biorxiv.org/content/10.1101/2025.02.12.637804v1

This is massive, looking forward to keeping an eye on these fascinating collaborations between "New" sequencing platforms and @10xgenomics.bsky.social

First major get together of all like minded people. Get along and interact with all the companies that will be there highlighting their latest technologies.

#fog2025