noam

New from our lab in @narjournal.bsky.social:
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5

Recently rewatched it, definitely holds up!

Way more politics than in the movie but it was great! Good example where the movie and book are both really good and don't meaningfully spoil one another.

Using a protease to activate a proenzyme nuclease is just a very sensible strategy, eukaryotes and prokaryotes can all agree!

Untangling phage immunity systems can be really challenging but @owentuck.bsky.social and team used phylogeny and biochemistry beautifully to show how a pair of genes got repurposed as a component in multiple defence systems.

My understanding is that it was higher than that, closer to 14%, where did you get this number?

Revisiting Trade-offs between Rubisco Kinetic Parameters Rubisco is the primary carboxylase of the Calvin cycle, the most abundant enzyme in the biosphere, and one of the best-characterized enzymes. On the basis of correlations between Rubisco kinetic param...

@flamholz.bsky.social and I have this paper attempting to understand the tradeoffs in carbon fixation by rubisco. Tl;dr: "not extremely clear cut"

pubs.acs.org/doi/10.1021/...

@synbio1.bsky.social solarpunk

An endless frontier of fun

I will definitely be doing this!!

Escherichia coli selection strains for growth-coupled metabolic engineering Synthetic metabolism has the potential to transform carbon capture, bioremediation, or bioproduction strategies. To transfer metabolic designs from an in vitro context to living model systems such as ...

Escherichia coli selection strains for growth-coupled metabolic engineering

@cp-trendsbiotech.bsky.social Review by @helenasm.bsky.social, @beaubd.bsky.social, and Tobias Erb at @mpimicrobiomarburg.bsky.social

www.cell.com/trends/biote...

In vivo directed evolution of an ultrafast Rubisco from a semianaerobic environment imparts oxygen resistance | PNAS Carbon dioxide (CO2) assimilation by the enzyme Ribulose-1,5-bisphosphate Carboxylase/Oxygenase (Rubisco) underpins biomass accumulation in photosy...

Nice work showing it is possible to engineer increased oxygen tolerance of fast rubiscos using in vivo directed evolution via @pnas.org doi.org/10.1073/pnas...

Specificity is still really tricky, the underlying mechanism remains almost entirely unexplained and red algal assembly is not yet understood (as you point out). But the field is moving quickly!

I loved this paper!

A SynBio explosion: a whole new world for Rubisco engineering This article comments on:Archer J, Kathpalia M, Lee B, Li S, Wang T. 2025. Effects of chaperone selectivity on the assembly of plant Rubisco orthologs in E

SynBio: it’s what plants crave
doi.org/10.1093/jxb/...
J Exp Bot Insights article from *Dan Hong Loh* - she discusses the impacts of Rubisco SynBio tool expansions from Archer et al. 2025 (doi.org/10.1093/jxb/...).

Someone had to kickstart the conversation about squinches #squinch

@norvid-studies.bsky.social @flamholz.bsky.social

That's amazing!!

Muqarnas - Wikipedia

Muqarnas are the "Oops, only spandrels" of cathedral ceilings.
#gould #levontin #sanmarco #Pangloss #adaptationist #evolution #mosques #architecture #pendentive #squinch #persia #capncrunch #iwan #mihrab #corbel #stalactite #honeycomb

en.wikipedia.org/wiki/Muqarna...

Can you do a comparison of cumulative job postings over the season and compare to previous years?

The main one I've wanted is a scarless, targeted paster. Sort of similar to TDNA from agro or prime editing, just simplified. Bonus points for a viral-like delivery mechanism.

It's almost as if the headlines are converging around common words and ideas

Nam Chua!

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

Exciting new work from Sattely lab with collaborator @pollyfordyce.bsky.social and coworkers @stanford-chemh.bsky.social, solving they biosynthesis of taxol!

www.nature.com/articles/s41...

Barbara McClintock portrait

🧬🌽 Happy Transposon Day! 🌽🧬

Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025

This alphabet has 20 letters, and therefore integrates well with existing tree inference software (to which a 3di alignment looks like a regular old protein alignment). This means we can use this to infer trees.

6/10 dCas12f-Sigma factors are able to recruit their native RNA polymerase (RNAP) to drive RNA-guided transcription at programmable sites. Remarkably, we were able to generate RNA (see RNA-seq) without relying on promoters in intergenic sequences, even within genes, and on either DNA strand.

Will it be recorded?

Does it shake or can it be shook?

340 for nadh plz