noam's Avatar

noam

@prywes.bsky.social

Rubisco, protein engineering and photosynthesis. Starting a lab in the Cambridge biochemistry department this fall. pryweslab.org

218 Followers  |  205 Following  |  91 Posts  |  Joined: 09.08.2023  |  2.3066

Latest posts by prywes.bsky.social on Bluesky

Preview
Improving Rubisco for sustainable crop production at Gatsby Charitable Foundation on FindAPhD.com PhD Project - Improving Rubisco for sustainable crop production at Gatsby Charitable Foundation, listed on FindAPhD.com

Another #PhD project available for applications in #photosynthesis with @ecarmosilva.bsky.social @sci-tech-lancaster.bsky.social looking at ways to improve Rubisco. Details below including how the successful nominee will play a direct role in shaping the project proposal tinyurl.com/2a8szv3y

02.10.2025 17:06 β€” πŸ‘ 8    πŸ” 5    πŸ’¬ 0    πŸ“Œ 2
Preview
A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.

Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...

01.10.2025 17:56 β€” πŸ‘ 102    πŸ” 51    πŸ’¬ 3    πŸ“Œ 2
Preview
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

15.09.2025 18:03 β€” πŸ‘ 160    πŸ” 67    πŸ’¬ 8    πŸ“Œ 7

New Paper Alert! β€œThe diversity of PET-degrading enzymes: A review”. We present a database of PET-plastic hydrolases, including sequence, structure, and function. From this, we discuss the distribution, efficiency, stability, and potential for biodegradation of PETases.

14.09.2025 06:59 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Sort of a recapitulation

05.09.2025 02:26 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

We move in two weeks 😱

04.09.2025 22:09 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Congrats!! πŸͺ°

04.09.2025 20:28 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

I am thrilled to announce that I just opened my lab at New York University in @nyucns.bsky.social and Biology! Our work will explore the richness of animal behavior, dissecting the genetic and circuit mechanisms that shape its evolution.

04.09.2025 17:13 β€” πŸ‘ 49    πŸ” 12    πŸ’¬ 6    πŸ“Œ 1
Assistant Professor- Department of Plant Biology Duties & Responsibilities

We are hiring! The #PlantBio department at UIUC is looking to recruit an Assistant Professor in Plant-Fungal interactions. Application deadline is October 31st @dallingjim.bsky.social see the link below for more details:
illinois.csod.com/ux/ats/caree...

04.09.2025 13:48 β€” πŸ‘ 10    πŸ” 17    πŸ’¬ 1    πŸ“Œ 2
Post image

Applications are invited for our Independent Research Fellowship scheme to support early career scientists in establishing their own research groups. The deadline is 24 October 2025 and further details of how to apply are here: www.bioc.cam.ac.uk/research/ind...

03.09.2025 09:41 β€” πŸ‘ 2    πŸ” 6    πŸ’¬ 0    πŸ“Œ 1
Preview
Polyphyodont - Wikipedia

I think we should also consider the degree of our deciduous teething, the polyphyodonts have some advantages but so do the monophyodonts...
en.wikipedia.org/wiki/Polyphy...

31.08.2025 17:09 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Post image

Professor Susanne von Caemmerer FRS and Professor Graham Douglas Farquhar FRS are jointly awarded the Royal Medal (Biological) 2025 for refining the ways we monitor and model photosynthesis in leaves from molecular to global scales. #RSMedals https://royalsociety.org/medals-and-prizes/royal-medals/

28.08.2025 10:30 β€” πŸ‘ 49    πŸ” 18    πŸ’¬ 1    πŸ“Œ 3
Preview
Divergent viral phosphodiesterases for immune signaling evasion Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase...

Excited to share our new preprint co-led by @jnoms.bsky.social!

Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.

22.08.2025 19:02 β€” πŸ‘ 42    πŸ” 28    πŸ’¬ 2    πŸ“Œ 2

!!! Yes!

20.08.2025 05:18 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I love this diagram

18.08.2025 13:29 β€” πŸ‘ 34    πŸ” 13    πŸ’¬ 2    πŸ“Œ 1
Post image

The first paper from my PhD is out now! doi.org/10.1111/jeu....

We describe a new photosynthetic #Paulinella species from a brackish beach in British Columbia πŸ‡¨πŸ‡¦

Big thanks to the co-authors Maia Palka and @alive-in-the-ocean.bsky.social, and my supervisor @fburki.bsky.social

#protistsonsky

18.08.2025 11:36 β€” πŸ‘ 58    πŸ” 17    πŸ’¬ 9    πŸ“Œ 2
Post image

You can't let those macroeconomic headwinds tell you how to live your life

15.08.2025 21:03 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

I'm still waiting for the John Henry moment for lab robotics

12.08.2025 03:24 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

🚨 We’re hiring! The Burlacot Lab @carnegiescience.bsky.social is recruiting a Postdoc to study how photosynthetic electron flows power COβ‚‚ fixation in algae 🌱🧫

Cutting-edge microscopy + biophysics + sustainability πŸš€

Apply: apply.interfolio.com/171656

10.08.2025 21:36 β€” πŸ‘ 3    πŸ” 4    πŸ’¬ 0    πŸ“Œ 1
Preview
Postdoctoral Fellow, Hattie Chung Lab (Yale School of Medicine) Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

Our lab at Yale @yalemedicine.bsky.social seeks #postdocs with in vivo expertise to pioneer research at the intersection of tissue remodeling & aging. Work with us to uncover immunological & vascular drivers of ovarian aging, applying single-cell, spatial omics, and ML! jobrxiv.org/job/yale-uni...

08.08.2025 18:05 β€” πŸ‘ 10    πŸ” 8    πŸ’¬ 1    πŸ“Œ 0
Preview
Structures of Naked Mole-Rat, Tuco-Tuco, and Guinea Pig Ribosomes: Is rRNA Fragmentation Linked to Translational Fidelity? Ribosomes are central to protein synthesis in all organisms. Among mammals, the ribosome functional core is highly conserved. Remarkably, two rodent species, the naked mole-rat (NMR) and tuco-tuco dis...

nam02.safelinks.protection.outlook.com?url=https%3A...

06.08.2025 11:27 β€” πŸ‘ 9    πŸ” 4    πŸ’¬ 2    πŸ“Œ 0
Post image Post image

Congrats to our savage lab undergrads on their research and presentations in our inaugural undergrad research symposium πŸŽ‰πŸ₯³

05.08.2025 20:56 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Honored to be among this amazing group and be recognized for the early career research award in memory of GΓΌnter Blobel

04.08.2025 23:21 β€” πŸ‘ 42    πŸ” 6    πŸ’¬ 10    πŸ“Œ 0
Post image

New from our lab in @narjournal.bsky.social:
We dissect the folding dynamics of a fundamental element of RNA secondary structureβ€”a stem-loopβ€”at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5

31.07.2025 02:27 β€” πŸ‘ 21    πŸ” 8    πŸ’¬ 1    πŸ“Œ 2

Recently rewatched it, definitely holds up!

30.07.2025 01:45 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Way more politics than in the movie but it was great! Good example where the movie and book are both really good and don't meaningfully spoil one another.

29.07.2025 22:51 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Using a protease to activate a proenzyme nuclease is just a very sensible strategy, eukaryotes and prokaryotes can all agree!

29.07.2025 17:20 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Untangling phage immunity systems can be really challenging but @owentuck.bsky.social and team used phylogeny and biochemistry beautifully to show how a pair of genes got repurposed as a component in multiple defence systems.

29.07.2025 17:20 β€” πŸ‘ 9    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0

My understanding is that it was higher than that, closer to 14%, where did you get this number?

29.07.2025 16:54 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Preview
Revisiting Trade-offs between Rubisco Kinetic Parameters Rubisco is the primary carboxylase of the Calvin cycle, the most abundant enzyme in the biosphere, and one of the best-characterized enzymes. On the basis of correlations between Rubisco kinetic param...

@flamholz.bsky.social and I have this paper attempting to understand the tradeoffs in carbon fixation by rubisco. Tl;dr: "not extremely clear cut"

pubs.acs.org/doi/10.1021/...

27.07.2025 03:31 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

@prywes is following 20 prominent accounts