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noam

@prywes.bsky.social

Rubisco, protein engineering and photosynthesis at the Cambridge Biochemistry Department. pryweslab.org

229 Followers  |  214 Following  |  96 Posts  |  Joined: 09.08.2023  |  1.8495

Latest posts by prywes.bsky.social on Bluesky

Fabulous supervisors include @pdchristine.bsky.social @yiliangding.bsky.social @pierrebuscaill.bsky.social caill.bsky.social @morganlab.bsky.social and many more....

Webinar on Dec 10th - details in ads. Deadline Jan 19th.

(UK students only unfortunately)

27.11.2025 21:05 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Engineering plant rubisco enzymes through high-throughput enzyme assays and cryo-EM (Plant BioDesign Cambridge project) at University of York on FindAPhD.com PhD Project - Engineering plant rubisco enzymes through high-throughput enzyme assays and cryo-EM (Plant BioDesign Cambridge project) at University of York, listed on FindAPhD.com

🌱🚨 Funded PhD for UK students πŸ‡¬πŸ‡§πŸŒΏ
Take a look at this Plant BioDesign Doctoral Training Program.
Come work with me and @michaelwebster.bsky.social to study plant rubiscos. High throughput biochem at Cambridge and Cryo-EM techniques at the John Innes Centre.

www.findaphd.com/phds/project...

03.12.2025 11:22 β€” πŸ‘ 4    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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A synthetic bacterium that degrades and assimilates poly(ethylene terephthalate) Polyethylene terephthalate (PET) is the fourth most commonly used plastic worldwide. Like all plastics, post-consumer PET is poorly managed and accumulates in the environment, posing significant ecolo...

Paper alert!
We have created a bacterium that eats plastic! We named it PETBuster! Great work by PhD student Dekel Freund @dekel-freund.bsky.social.
www.biorxiv.org/content/10.1...

01.12.2025 10:11 β€” πŸ‘ 34    πŸ” 11    πŸ’¬ 1    πŸ“Œ 3
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The cold water tintinnid ciliate Parafavella elegans & some diatoms from the Chukchi Sea last summer- almost the end of the Arctic samples....

26.11.2025 14:00 β€” πŸ‘ 29    πŸ” 5    πŸ’¬ 3    πŸ“Œ 1

New carboxylases (and new pathway reactions) expand the possibilities for alternative carbon fixation cycles. Amazing work from the Claassens lab!! (Vittorio in particular, this is a huge body of work).
This changes my assumptions around what can be expected from future new cycles. ♻️

26.11.2025 07:14 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

πŸ”₯

23.11.2025 23:23 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Rubisco is slow across the tree of life

@omc111.bsky.social

www.pnas.org/doi/10.1073/...

20.11.2025 20:15 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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The virulence gene ToxB is both amplified and disrupted by transposons in the wheat pathogen Pyrenophora tritici-repentis ### Competing Interest Statement The authors have declared no competing interest. Agriculture and Agri-Food Canada, https://ror.org/051dzs374 Alberta Grain Saskatchewan Wheat Development Commissio...

Our latest pre-print on TE-mediated tandem duplication of the ToxB effector is now online...still a puzzle for us but we think it is in a Helitron! Together with amazing collaborators, Reem Aboukhaddour and Ryan Gourlie #TE #fungi
www.biorxiv.org/content/10.1...

18.11.2025 16:22 β€” πŸ‘ 33    πŸ” 14    πŸ’¬ 0    πŸ“Œ 0
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Recurrent acquisition of nuclease-protease pairs in antiviral immunity Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...

Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/...

Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social

13.11.2025 22:15 β€” πŸ‘ 80    πŸ” 35    πŸ’¬ 5    πŸ“Œ 4
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We are delighted that our Alkis Seraphim Memorial Lecturer for 2025 is Prof Ben Lehner speaking on 'Mapping the energetic and allosteric structures of proteins at scale' on 4 December at 4.30pm in the Babbage Lecture Theatre. Further details and book here: www.eventbrite.com/e/alkis-sera...

10.11.2025 12:57 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 2

excited to see this one with @leahtaylorkearney.bsky.social @prywes.bsky.social et al. out, bringing a truly interdisciplinary (comparative genomics/phylogeny + biochemistry) lens to our favorite enzyme rubisco

07.11.2025 20:05 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Arts and Sciences?

01.11.2025 21:08 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Redirecting

πŸ”₯πŸ”₯πŸ”₯ Friday Evening, Paper Out, Feierabend πŸ”₯πŸ”₯πŸ”₯

When evolution and enzyme engineering team up, they can convince microbes to assimilate sustainable carbon substrates preparing them for a life in a circular bioeconomy.

doi.org/10.1016/j.ym...

24.10.2025 17:00 β€” πŸ‘ 7    πŸ” 6    πŸ’¬ 3    πŸ“Œ 0

So any of these homologs maintain linear chromosomes in bacteria?

18.10.2025 19:30 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
The image shows several elongated rhomboid-shaped cells, filled with ovoid chrooroplasts in magenta, as well as a network of bubble-like vacuoles.

The image shows several elongated rhomboid-shaped cells, filled with ovoid chrooroplasts in magenta, as well as a network of bubble-like vacuoles.

Here are some β€œleaf” or phyllid cells from moss Physcomitrium patens gametophore. Cells are expressing a green fluorescence marker that labels the vacuolar membrane. Chloroplasts' autofluorescence is in magenta.
Can you spot dividing chloroplasts?
#microscopymonday #moss #plantcells

13.10.2025 14:40 β€” πŸ‘ 94    πŸ” 27    πŸ’¬ 2    πŸ“Œ 0
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Applications are open for a fully funded PhD studentship: "Matchmaker: Prioritising the best cell line for expressing target proteins using CRISPR and machine learning" at @cambiochem.bsky.social and AZ.

⏳ Closing date: 31 October 2025
πŸ“† Start date: 1 October 2026
πŸ”— www.cam.ac.uk/jobs/astraze...

11.10.2025 12:25 β€” πŸ‘ 3    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Improving Rubisco for sustainable crop production at Gatsby Charitable Foundation on FindAPhD.com PhD Project - Improving Rubisco for sustainable crop production at Gatsby Charitable Foundation, listed on FindAPhD.com

Another #PhD project available for applications in #photosynthesis with @ecarmosilva.bsky.social @sci-tech-lancaster.bsky.social looking at ways to improve Rubisco. Details below including how the successful nominee will play a direct role in shaping the project proposal tinyurl.com/2a8szv3y

02.10.2025 17:06 β€” πŸ‘ 11    πŸ” 8    πŸ’¬ 0    πŸ“Œ 3
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A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.

Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...

01.10.2025 17:56 β€” πŸ‘ 109    πŸ” 54    πŸ’¬ 3    πŸ“Œ 2
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Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

15.09.2025 18:03 β€” πŸ‘ 162    πŸ” 69    πŸ’¬ 7    πŸ“Œ 7

New Paper Alert! β€œThe diversity of PET-degrading enzymes: A review”. We present a database of PET-plastic hydrolases, including sequence, structure, and function. From this, we discuss the distribution, efficiency, stability, and potential for biodegradation of PETases.

14.09.2025 06:59 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Sort of a recapitulation

05.09.2025 02:26 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

We move in two weeks 😱

04.09.2025 22:09 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Congrats!! πŸͺ°

04.09.2025 20:28 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

I am thrilled to announce that I just opened my lab at New York University in @nyucns.bsky.social and Biology! Our work will explore the richness of animal behavior, dissecting the genetic and circuit mechanisms that shape its evolution.

04.09.2025 17:13 β€” πŸ‘ 53    πŸ” 12    πŸ’¬ 6    πŸ“Œ 1
Assistant Professor- Department of Plant Biology Duties & Responsibilities

We are hiring! The #PlantBio department at UIUC is looking to recruit an Assistant Professor in Plant-Fungal interactions. Application deadline is October 31st @dallingjim.bsky.social see the link below for more details:
illinois.csod.com/ux/ats/caree...

04.09.2025 13:48 β€” πŸ‘ 10    πŸ” 17    πŸ’¬ 1    πŸ“Œ 2
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Applications are invited for our Independent Research Fellowship scheme to support early career scientists in establishing their own research groups. The deadline is 24 October 2025 and further details of how to apply are here: www.bioc.cam.ac.uk/research/ind...

03.09.2025 09:41 β€” πŸ‘ 2    πŸ” 6    πŸ’¬ 0    πŸ“Œ 1
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Polyphyodont - Wikipedia

I think we should also consider the degree of our deciduous teething, the polyphyodonts have some advantages but so do the monophyodonts...
en.wikipedia.org/wiki/Polyphy...

31.08.2025 17:09 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Professor Susanne von Caemmerer FRS and Professor Graham Douglas Farquhar FRS are jointly awarded the Royal Medal (Biological) 2025 for refining the ways we monitor and model photosynthesis in leaves from molecular to global scales. #RSMedals https://royalsociety.org/medals-and-prizes/royal-medals/

28.08.2025 10:30 β€” πŸ‘ 49    πŸ” 18    πŸ’¬ 1    πŸ“Œ 3
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Divergent viral phosphodiesterases for immune signaling evasion Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase...

Excited to share our new preprint co-led by @jnoms.bsky.social!

Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.

22.08.2025 19:02 β€” πŸ‘ 43    πŸ” 28    πŸ’¬ 2    πŸ“Œ 3

!!! Yes!

20.08.2025 05:18 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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