De Camilli Lab

Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...

"Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C" out now in PLOS Biology
journals.plos.org/plosbiology/...

29.09.2025 13:47 — 👍 16    🔁 10    💬 0    📌 1

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL

10.04.2025 14:17 — 👍 50    🔁 26    💬 0    📌 1

New research from @pdc-lab.bsky.social & collaborators finds that the bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage; #Parkinsons-associated LRRK2 is also recruited but at later stage
www.nature.com/articles/s41...

10.04.2025 09:59 — 👍 3    🔁 2    💬 1    📌 0