Dr Ross McInnes

Epistasis and co-adaptation in bacterial genome evolution Nature Reviews Genetics - Bacterial genome evolution is shaped by epistasis, which can constrain or promote specific evolutionary paths. The authors review how integrating the effects of epistatic...

I’ve spent a lot of time over the past two years thinking about genome evolution and how recent research revealing complex gene-gene interactions has complicated traditional ‘gene-centric’ genomic approaches to evolution. So here is a review that consolidates these thoughts!

rdcu.be/e6pHY

Headshot of Jeff Cole

We were deeply saddened to learn of the death of Professor Jeff Cole, a long-standing member who held many positions in the Society. Jeff was elected an Honorary Member in 2011. You can read his full obituary here: microb.io/46xYzkz

Amazing work from @freyaallen.bsky.social and @prob91.bsky.social. I truly believe that Rob is the Sherlock Holmes of MGEs and one of the leaders in the field of artisanal bioinformatics😉!

Our review is now available #OpenAccess online and as formatted PDF doi.org/10.1093/fems...

Resistance to last-resort antibiotics in enterococci Abstract. The genus Enterococcus comprises a diverse group of species, many of which are commensal members of the gut microbiota of humans and animals. The

Delighted that our review on resistance to last-resort antibiotics in Enterococci has been published in FEMS Microbiology Reviews

academic.oup.com/femsre/advan... (accepted manuscript version)

TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.

Congratulations Freya! Well done for all your hard work!

Our little Cherry tree is losing its leaves in a beautiful show and the sweet peas are already poking their heads up ready for next year! 🌸

Noodlococcus is out in the wild!

🔬Join us for our upcoming Cancer Immunology Workshop: 'Lessons from the Microbes Within Us; Developing Next Generation Immunotherapeutics'

📅23-24 October 2025
📍CRUK Scotland Institute, Glasgow

Abstract deadline: 26 September
Register by: 10 October

crukscotlandinstitute.ac.uk/immuno_works...

A lovely essay on scientific supervision

Well done to Freya and Rob, a manuscript a long time in the making!

As is @prob91.bsky.social

Do you miss living in Birmingham? What do you think? 😂

The antisocial behaviour in Milngavie is getting out of hand!

Orchids on our evening walk! 🪻

Beautiful!

Check out this story with Noodlococcus as the star of the show!

Excited to share something with you all later this week… 🧫🦠🍜👀

Garden update...

Thank you so much to everyone who sponsored me to walk from Glasgow Green to Loch Lomond in the Kilt walk. My feet are only recovering now, but it was worth it to raise some money for CRUK.

Happy big birthday @roscobacterium.bsky.social ! Celebrated in style at lab meeting with Tiramisu made by @celespin.bsky.social 😋

Ross's fundraiser for Cancer Research UK Help Ross McInnes raise money to support Cancer Research UK

I am raising money for Cancer Research UK by walking 23 miles in the Kiltwalk Mighty Stride on the 27th of April. Any donations would be greatly appreciated! www.justgiving.com/page/ross-mc...

Lovely few days in Copenhagen, off to Malmö today!

Pretty cool having kingfishers right next to our institute! @cruk-si.bsky.social

Busy day planting out in the garden! 🏡☀️

Over 1,000 icddr,b staffers receive termination letters The International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) has suffered a major setback due to a new policy by the United States, with over 1,000 employees reportedly receiving ter...

Thinking of colleagues at icddr,b who are being severely affected by the cuts to USAID. World class research is carried out at icddr,b and the world is in a much more vulnerable position without it! www.dhakatribune.com/bangladesh/d...

The @mmimic.bsky.social lab is open to collaborations and we are particularly interested in using human samples from across Scotland in our research!

As the resident microbiologist in the lab, I am investigating the adaptation of STm to the TME using transcriptomics, next gen sequencing, and molecular microbiology. I will also be drawing on my experience to expand our work on the interaction between the gut microbiome, BCT, and the immune system.

Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity | EMBO Molecular Medicine imageimageAttenuated Salmonella show promise as cancer therapeutics, yet T cells play no role in efficacy, limiting combined checkpoint blockade therapies or induction of immune memory. Improving T ce...

In a recent paper (www.embopress.org/doi/full/10....) the @mmimic.bsky.social lab beautifully demonstrated the interplay between S. Typhimurium and T cells in the tumour microenvironment, and how T cell activation can be reinvigorated by altering S. Typhimurium metabolism.