Maddy Comerford

GitHub - hadley/genzplyr: dplyr but make it bussin fr fr no cap dplyr but make it bussin fr fr no cap. Contribute to hadley/genzplyr development by creating an account on GitHub.

Do you teach #rstats? Do your students complain about how lame and old-fashioned dplyr is? Don't worry: I have the solution for you: github.com/hadley/genzp....

genzplyr is dplyr, but bussin fr fr no cap.

Napoleon's retreat from Moscow CREDIT Barbieri et al., Current Biology

DNA from Napoleon’s 1812 army identifies the pathogens likely responsible for the army’s demise during their Russian retreat. www.cell.com/current-biol...

Nicolás Rascovan & colleagues
@currentbiology.bsky.social

A high-coverage genome from a 200,000-year-old Denisovan https://www.biorxiv.org/content/10.1101/2025.10.20.683404v1

An early East Asian lineage with unexpectedly low Denisovan ancestry Yang et al. study Denisovan ancestry in ancient and present-day humans. In contrast to other East Asians, genomic comparisons suggest that the Jomon derived most of their ancestry from a deep lineage ...

In a new paper led by Jiaqi Yang we trace the distribution of Denisovan introgressed DNA in ancient modern human genomes over time.

www.cell.com/current-biol...

My non-MPRA phd work! 😄

GitHub - R-CoderDotCom/ggcats: The geom you always wished for adding cats to ggplot2 The geom you always wished for adding cats to ggplot2 - R-CoderDotCom/ggcats

Just discovered {ggcats} and yes, it does exactly what you think: adds cats to your ggplots. 🐈📈 Because sometimes your data visualisation needs a little more purr-sonality.

👉 github.com/R-CoderDotCo...

#RStats #ggplot2 #dataviz #catsinstats

Figure 1. Introgression and its genomic landscapes.

"Decoding Genomic Landscapes of Introgression"
by Martin Kuhlwilm (@kuhlwilm.bsky.social) & co

"The detection of introgressed loci has evolved into a diverse methodological field encompassing summary statistics, probabilistic modeling, and supervised learning."

authors.elsevier.com/sd/article/S...

🧪🖥️🧬 It's here!! Our second MPRA, which is totally different from the first. For starters, there's no human sequences anywhere!

Instead there's marsupials, wolves, pandas and a lot of hard work from lab members past & present, chief amongst them @navya-shukla.bsky.social (looking for a postdoc btw)

‘Dragon Man’ skull belongs to mysterious human relative At long last, scientists have a nearly complete cranium from hominins known as Denisovans

At long last, scientists have a nearly complete cranium from hominins known as Denisovans. scim.ag/4e7QdT4

So excited that this work is finally out! 🎉 Thank you to everyone involved in this work, and to all co-authors for all your efforts into getting this one out!

Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans Interbreeding between anatomically modern humans and archaic hominins has contributed to the genomes of present-day human populations. However, our understanding of the specific gene regulatory conseq...

Very interesting Massive Parallel Reporter Assay study by @ee-reh-neh.bsky.social and colleagues, refining our understanding of the impact of Neanderthal & Denisovan #introgression in modern Papuans (special focus on immune cell types) 🧪🧬
www.biorxiv.org/content/10.1...

🎉 This paper has been a long time and a labour of love (and hardship) for multiple group members, but, finally: we MPRA'ed 25k introgressed variants (Denisovan and Neanderthal) segregating at allele frequencies > 0.15 in humans today to evaluate their potential to regulate gene expression.

Interested in the impact of Denisovan and Neanderthal introgression, or using high-throughput assays to answer evolutionary questions? Check out our work MPRA’ing Denisovan and Neanderthal variants in present-day humans to characterise their impact on gene expression ⬇️

@maddycomerford.bsky.social

Archaic introgression is not evenly distributed between modern human populations. 🧬🌍

Showing differentially active Denisovan SNP predicted to regulate TNFAIP3; genotype at this SNP correlates with TNFAIP3 expression in a single-cell RNAseq dataset.

#HumanEvo25

Molecular analysis of a hominin mandible from Taiwan reveals the lineage and sex of the individual.

A fossil Pleistocene-age hominin jawbone discovered in Taiwan has now been identified as belonging to a Denisovan, finds a new study in Science.

The results provide direct molecular evidence that Denisovans occupied diverse climates and offer new insights into this hominin lineage. scim.ag/4joSUBh

Splicing in ancient DNA from a greek poet into a wolf embryo to make Canis orpheusis, the lyre wolf.

Dire wolves remain very extinct Despite what you are being fed, de-extinction is a con, full of gloss, bullshit and ghoulish greed.

The resurrection circus keeps clowning, but make no mistake, Dire wolves remain very extinct.

An angry, sweary piece by a frustrated geneticist.

arutherford.substack.com/p/dire-wolve...

POLAR BEAR IS THE #2025MMM CHAMPION!!!!

ARTWORK by @veppart.bsky.social!

A polar bear is shown in a portrait, facing to the left, mouth open in a roar. Its breath is visible as a cloud of steam

#2025MMM #EliteTrait #DivisionTuxedoStyle #DivisionChampion #TeamPolarBear Art by Valeria Pellicer @veppart.bsky.social #mammals #sciart

Photo array concealing the 2025 bracket from view- images include "So it begins" for LOTR the Two Towers & Rafiki saying "It is Time" from the Lion King. The bracket guide cover of a polar bear and the pulp magazine cover that says Exciting Tales of Science!

MARCH MAMMAL MADNESS BRACKET DROP!!!! #2025MMM
Did you get the combatants you dreamed of?
HAPPY RESEARCHING THE SPECIES!!
libguides.asu.edu/MarchMammalM...

Thrilled with the release of this Terra Australis volume about the West New Guinea, exploring the rich human past of this fascinating region. Honored to have contributed chapters to this volume.

*increasing the line width on my figure*

Hehehe, the plot thickens.

Had a wonderful few days at Lorne Genome 2025! Thank you to all involved for such a great conference in such a beautiful part of the world 🌊☀️🧬

Parafilm watercolor

Maddy Comerford using massively parallel reporter assay to characterise activity of Denisovan and Neanderthal sequences in the modern genome identifying a denisovan snp with immune specific expression. #lornegenome #lornegenome2025