@jourdainlab.bsky.social
Swiss-Belgian biologist, assistant professor @UNIL with interest in mitochondria, energy metabolism, innate immunity and systems biology.
‼️ We're looking for a postdoc to join our team starting January 1st, 2026! ‼️
Are you curious about how exercise promotes positive changes at the molecular level in obesity and diabetes? If so, consider applying or reach out with any questions.
ddz.de/job/postdoct...
ddz.de/en/research/...
Thanks Anupam!
28.07.2025 16:41 — 👍 0 🔁 0 💬 0 📌 0Congrats to PhD student @marcellharhai.bsky.social , who joined the lab 2y ago (!) and led this work, to second author M. Foged, and to all our collaborators!
We are thankful to our funding sources including the @FSRMM, Novartis and @snsf.ch.
@dib-unil.bsky.social @fbm-unil.bsky.social
Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports! 🎉
🧫 New galactose #CRISPR screen
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂 Mito defects in #Menieres
www.cell.com/cell-reports...
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
23.07.2025 20:50 — 👍 22 🔁 13 💬 2 📌 2
Uridine: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...
a great not-to-miss piece from the @lyssiotislab.bsky.social
🌿 Bravo aux 12 laboratoires certifiés LEAF @fbm-unil.bsky.social
👏 Arber Lab, Bagni Lab, Chatton Lab, Du Pasquier Lab, Jourdain Lab, LPA, M-Lab, Martinon Lab, Rebsamen Lab, Suter Lab, Thome Lab, Widmann Lab.
➡️ www.unil.ch/news/1747834...
#LEAF #recherche #durable
Powerful new method to diagnose mito disease!
(and not only because in my heart proteomics>>>sequencing)
Job alert: My lab at Emory University in vibrant Atlanta is recruiting a postdoc to study #mitochondrialbiology and #metabolism! Please help spread the word! (1/3) @cp-cellmetabolism.bsky.social @natmetabolism.nature.com
06.05.2025 14:12 — 👍 2 🔁 3 💬 1 📌 0
🚀 Boost your brand at EUROMIT 2026!
🎯 Sponsorship opportunities open in May 2025, but you can express your interest now by dropping us a line at 👉 euromit2026@univ-angers.fr
Don't miss this unique opportunity for your business! 💼✨
#euromit2026 #mitochondria #sponsorship #businessopportunity
Exciting News: Learn about the Speakers of Euromit 2026!
We are happy to announce the amazing speakers for Euromit 2026, the leading congress on mitochondrial pathology.🌍✨
📢 See the full list ! 👇
#euromit2026 #mitochondria #science #innovation #angers
Interested in #InnateImmunity ? Register now to secure your spot — abstracts can be submitted later!
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Congratulations!!! 👏🏼👏🏼👏🏼
19.03.2025 18:18 — 👍 1 🔁 0 💬 0 📌 0Thank you for reading this tread, and thank you to all the co-authors and funding agencies!
@snsf-ch.bsky.social
@fbm-unil.bsky.social
@dib-unil.bsky.social
9/9
This has therapeutic implications! We show that low PRPP levels in NUDT5-KO cells prevent the conversion of nucleobase analogs #5FU #6TG into their toxic nucleosidic forms, leading to chemotherapy resistance.
Could the NUDT5 status of a tumor inform treatment?
#PersonalizedMedicine
8/9
The NUDT5-PPAT interaction appears to be disrupted by PRPP in a #physiological feedback loop! Indeed PRPP serves not only as the PPAT substrate but also as its main #allosteric activator!
⚙️ High PRPP → dissociation of NUDT5 from PPAT → increased purine synthesis
7/9
We show that the interaction of NUDT5 with PPAT prevents PPAT’s full activity and maintains the #PRPP pool, which is the ribose donor common to both purines and pyrimidines!
⚙️ Low NUDT5 → hyperactive PPAT → no more PRPP for pyrimidines
6/9
🧩 We made two key observations for the mechanism:
(1) NUDT5 binds to and oligomerizes with #PPAT, the first and rate-limiting enzyme in purine synthesis
(2) PPAT depletion rescues pyrimidine synthesis in NUDT5-KO cells #epistasis
But why pyrimidines?!?
5/9
And so, we focused on hit number 4: #NUDT5 (#NUDIX5)!
While we confirmed low pyrimidine levels in NUDT5-KO cells, we were surprized to find an increase in #purines, indicating nucleotide imbalance.
How is this possible, and how is NUDT5 involved?
4/9
#Uridine is the main substrate for #pyrimidine salvage, and uridine supplementation is given to patients with mutations in de novo pyrimidine synthesis #Vistogard #Xuriden 💊
🎯 We screened in +/- uridine and found the three pyrimidine enzymes as hits 1-2-3!
#CAD #DHODH #UMPS
3/9
Nucleotides are essential for life and can be synthesized de novo or obtained through #salvage. Genes involved in de novo synthesis are essential, except when a substrate for salvage is provided.
🧫 We designed a #CRISPR screen comparing growth with and without salvage.
2/9
🚨 New preprint available! Third and final in the #CRISPR screen series!🚨
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
🚨Registrations are open🚨
Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.
Attendance is limited to 150 participants!
My lab at #EmoryUniversity is seeking a #Postdoc candidate with expertise in #proteinbiochemistry to continue our exciting work on engineered protein therapies for #MitochondrialDiseases and #MetabolicDiseases. Email me to discuss this further. Please repost! #Proteinengineering #proteintherapy
12.02.2025 16:05 — 👍 6 🔁 4 💬 0 📌 0The place to be :)
31.01.2025 19:14 — 👍 0 🔁 0 💬 0 📌 0Thank you!
31.01.2025 16:57 — 👍 0 🔁 0 💬 0 📌 0Thank you Anupam!
31.01.2025 16:57 — 👍 0 🔁 0 💬 0 📌 0Thank you! We don't have (solid) evidence for that now, but that's definitely something we should look at!
31.01.2025 15:34 — 👍 0 🔁 0 💬 0 📌 0With a special thanks to our institution and funders: @dib-unil.bsky.social , @fbm-unil.bsky.social L, @snsf-ch.bsky.social , and the FSRMM 🙏🏻
5/5
This work is a direct follow up of our 2016 @Cell_Metabolism paper with @VamsiMootha (PMID 27667664).
It is also the fruit of our collaboration with #Menieres experts JA Lopez-Escamezo and A. Lysakowsi, and microscopy wizards @jclandoni.bsky.social and @sulianamanley.bsky.social !
4/5
