Jerelle Joseph

Want to learn about how we use computational approaches at different scales to study biomolecular condensates?
Check out our latest review, out in Advances in Physics X
@juliamaristany.bsky.social @alinaemelianova.bsky.social
@rcollepardo.bsky.social

www.tandfonline.com/doi/epdf/10....

Congratulations 🥳🥳🥳🥳🥳!!!!

Gave my last lecture yesterday. Started celebrating that, for the first time, I managed an entire semester without getting sick. Started feeling sick today 🤒…had a solid run though 😅

On the cover of #SoftMatter! Our work on condensate microstructure. Cover designed by Daniel Tan☺️ pubs.rsc.org/en/content/a...

Congrats everyone!! Nice to see this out! Huge shout out to Kieran! 🥳

Have not fully stopped but definitely way less now than before 💔

YouTube video by Physical Properties of the Cytoplasm Physical Properties of the Cytoplasm Seminar Series #25 | Allan Drummond

Very insightful reconsideration what Stress Granules might actually be good for!

Going back to the fundamentals & questions arising from Susan Lindquist's and Nancy Kedersha's work.

Amazing talk & scholarship by @drummondlab.bsky.social!

youtu.be/caAPToh8v0Q

Biomolecular condensate viscoelasticity is dictated by the interplay between single-molecule shape memory and mesh reconfigurability Biomolecular condensates are membraneless organelles that compartmentalize biological functions in living cells. Formed by the phase separation of biomolecules, condensates possess a wide range of mec...

Is there a way to directly connect microstructural dynamics of condensates to their mechanical response?

In his new pre-print, Pablo presents a “condensate Deborah number” that does just that!

www.biorxiv.org/content/10.1...

Wow 😩

Yasssssssss!!!!!! Congratulations Alex!!! 💃🏽💃🏽💃🏽💃🏽💃🏽💃🏽💃🏽💃🏽💃🏽

Theory of Condensate Size Control by Molecular Charge Asymmetry Biomolecular condensates are complex droplets comprising diverse molecules that interact by various mechanisms. Condensation is often driven by short-range attraction, but net charges can also mediate...

Out now in #ACSMacroLett: we demonstrate how molecular charge asymmetry can control the size of condensates! Work done in collaboration with @zwickergroup.bsky.social!!

Theory led by Chengjie Luo and simulations by @nathanieldhess.bsky.social!!

pubs.acs.org/doi/10.1021/...

Out now in #SoftMatter, our work on linking single molecule features, microstructure, and macroscopic properties of condensates! Led by Daniel Tan, a former undergrad student who is now pursuing a PhD in Computational biophysics, Dilimulati Aierken and Pablo Garcia!

pubs.rsc.org/en/content/a...

@ananyac2000.bsky.social (not sure why your tag got messed up, my bad)! 🥳🥳

Now out in #ProteinScience! Work led by the talented 🥳🥳@ananyac2000.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

Wow!

Nice work!!!

Who else gets nervous for the first lecture of the semester? It doesn’t matter how many times you’ve taught the course?!!! 😩#fallsemester

Our new approach, MAPPS, opens up new opportunities for screening small-molecule-condensate interactions on computers! Read the article here: pubs.acs.org/doi/full/10.10… 6/6

Leveraging these findings, as well as our Mpipi model for proteins, we developed a framework for probing small molecule partitioning into condensates — which is much faster that all atom simulations and allows us to model biologically relevant systems 5/

Our work suggests that small molecule selectivity of condensates can be engineered 4/

We also find that condensates enriched in hydrophobic residues exhibit stronger selectivity for small molecules. However those rich in polar residues can be selective for higher log P compounds that also have high dipole moments! 3/

By simulating ~65 atomistic system’s this work probes the partitioning landscape of four model condensates (varying in their hydrophobic residue content). We find that BOTH characteristics of condensates and small molecules dictate partitioning 2/

On the cover of JACS Au! @alinaemelianova.bsky.social’s work with Pablo and Daniel on using atomistic and residue-resolution coarse-grained simulation to probe interactions between small molecules and biomolecular condensates!! Cover designed by D. Aierken w/ Alina! 1/

I second that!!! ♥️

Prediction of Small-Molecule Partitioning into Biomolecular Condensates from Simulation Predicting small-molecule partitioning into biomolecular condensates is the key to developing drugs that selectively target aberrant condensates. However, the molecular mechanisms underlying small-mol...

Huge congratulations to @alinaemelianova.bsky.social Pablo and Daniel on their paper on small-molecule partitioning into condensates now published in JACS Au and selected as ACS Editor’s Choice!!! pubs.acs.org/doi/full/10....

Can't say enough about the Condensates program at @kitp-ucsb.bsky.social. Invigorating discussions, fantastic facilities, and a beautiful location (a place I consider "home"). Thanks to @weber-lab.bsky.social, @jerelleaj.bsky.social, @zwickergroup.bsky.social, and Frank Julicher for organizing!

Thanks Jeremy! It was wonderful having you join us. You always bring such insight and fresh perspectives! Hope you had a safe trip back

Few more days left to nominate a rising star in bioengineering! Self-nominations are welcomed!

“Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment”

The conference associated with our #KITP program on condensates runs for the next three days. Looking forward to meeting everyone and the discussions!

www.kitp.ucsb.edu/activities/b...

There’s nothing quite like #KITP! So grateful that we got the opportunity to put this on! The fun continues…🥰