Jerelle Joseph

Yasssssssss!!!!!! Congratulations Alex!!! 💃🏽💃🏽💃🏽💃🏽💃🏽💃🏽💃🏽💃🏽💃🏽

Theory of Condensate Size Control by Molecular Charge Asymmetry Biomolecular condensates are complex droplets comprising diverse molecules that interact by various mechanisms. Condensation is often driven by short-range attraction, but net charges can also mediate...

Out now in #ACSMacroLett: we demonstrate how molecular charge asymmetry can control the size of condensates! Work done in collaboration with @zwickergroup.bsky.social!!

Theory led by Chengjie Luo and simulations by @nathanieldhess.bsky.social!!

pubs.acs.org/doi/10.1021/...

Out now in #SoftMatter, our work on linking single molecule features, microstructure, and macroscopic properties of condensates! Led by Daniel Tan, a former undergrad student who is now pursuing a PhD in Computational biophysics, Dilimulati Aierken and Pablo Garcia!

pubs.rsc.org/en/content/a...

@ananyac2000.bsky.social (not sure why your tag got messed up, my bad)! 🥳🥳

Now out in #ProteinScience! Work led by the talented 🥳🥳@ananyac2000.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

Wow!

Nice work!!!

Who else gets nervous for the first lecture of the semester? It doesn’t matter how many times you’ve taught the course?!!! 😩#fallsemester

Our new approach, MAPPS, opens up new opportunities for screening small-molecule-condensate interactions on computers! Read the article here: pubs.acs.org/doi/full/10.10… 6/6

Leveraging these findings, as well as our Mpipi model for proteins, we developed a framework for probing small molecule partitioning into condensates — which is much faster that all atom simulations and allows us to model biologically relevant systems 5/

Our work suggests that small molecule selectivity of condensates can be engineered 4/

We also find that condensates enriched in hydrophobic residues exhibit stronger selectivity for small molecules. However those rich in polar residues can be selective for higher log P compounds that also have high dipole moments! 3/

By simulating ~65 atomistic system’s this work probes the partitioning landscape of four model condensates (varying in their hydrophobic residue content). We find that BOTH characteristics of condensates and small molecules dictate partitioning 2/

On the cover of JACS Au! @alinaemelianova.bsky.social’s work with Pablo and Daniel on using atomistic and residue-resolution coarse-grained simulation to probe interactions between small molecules and biomolecular condensates!! Cover designed by D. Aierken w/ Alina! 1/

I second that!!! ♥️

Prediction of Small-Molecule Partitioning into Biomolecular Condensates from Simulation Predicting small-molecule partitioning into biomolecular condensates is the key to developing drugs that selectively target aberrant condensates. However, the molecular mechanisms underlying small-mol...

Huge congratulations to @alinaemelianova.bsky.social Pablo and Daniel on their paper on small-molecule partitioning into condensates now published in JACS Au and selected as ACS Editor’s Choice!!! pubs.acs.org/doi/full/10....

Can't say enough about the Condensates program at @kitp-ucsb.bsky.social. Invigorating discussions, fantastic facilities, and a beautiful location (a place I consider "home"). Thanks to @weber-lab.bsky.social, @jerelleaj.bsky.social, @zwickergroup.bsky.social, and Frank Julicher for organizing!

Thanks Jeremy! It was wonderful having you join us. You always bring such insight and fresh perspectives! Hope you had a safe trip back

Few more days left to nominate a rising star in bioengineering! Self-nominations are welcomed!

“Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment”

The conference associated with our #KITP program on condensates runs for the next three days. Looking forward to meeting everyone and the discussions!

www.kitp.ucsb.edu/activities/b...

There’s nothing quite like #KITP! So grateful that we got the opportunity to put this on! The fun continues…🥰

I’m beyond proud of them! And so thankful for the graduate students and postdocs in the group who served as their day-to-day mentors! Looking forward to all they accomplish in the next chapter of their careers! ♥️♥️

This was a big week for the group! Our four seniors graduated and made us very proud. Ethan graduates as a Sachs Scholar, Ian secured several minors, Daniel won the MacCracken Senior Thesis Award from SEAS, and Caroline earned the highest awards in both CBE and Engineering!

Jerelle Joseph: seeing biomolecular condensates with computation - Nature Structural & Molecular Biology Jerelle Joseph is an assistant professor at the Department of Chemical and Biological Engineering and the Omenn–Darling Bioengineering Institute at Princeton University in New Jersey. We contacted Jer...

@natsmb.nature.com has launched new content this month, namely Q&As. This interview with Dr. Joseph @jerelleaj.bsky.social‬ www.nature.com/articles/s41... highlights what's great about these pieces. Get to learn about the scientist and their interesting work (consensates/computational biol)!

See u all in Santa Barbara!!

Jerelle Joseph: seeing biomolecular condensates with computation - Nature Structural & Molecular Biology Jerelle Joseph is an assistant professor at the Department of Chemical and Biological Engineering and the Omenn–Darling Bioengineering Institute at Princeton University in New Jersey. We contacted Jer...

Thanks to @natsmb.nature.com for interviewing on our work: “seeing biomolecular condensates with computation”

www.nature.com/articles/s41...

Thanks so much for being an incredible host! Enjoyed this visit!!

Yesterday was a great day to be at WashU!

Join our interdisciplinary team developing computational approaches to understand and engineer biomolecular condensates. We’re looking for a postdoc—please apply or share with interested persons! 👩🏽‍💻💧🧬
puwebp.princeton.edu/AcadHire/app...

Congratulations to our 4 seniors (Dan, Ethan, Caroline and Ian) on defending their theses today in the #CBE poster session!! We’re so proud! They’re heading off to Rockefeller, Caltech, Fancy Industry job, and UCLA in the fall! 3/4 were the first 3 juniors in the group. *Cue the tears*😭😭