Keisuke Ito

Today, Dr. John Crispino from St. Jude stopped by Einstein @einsteinmededu.bsky.social. I really enjoyed chatting with him, especially about fostering interactions and collaborations. Coincidentally, his new blog @isehsociety.bsky.social is so engaging and insightful!

Dr. Hideo Watanabe from Mount Sinai NY, my childhood friend and pulmonologist, stopped by Ito Lab today! He's been my role model since junior high—through med school, residency, PhD, postdoc, and now as a PI—always a year ahead. Had such great science chats! @einsteinmededu.bsky.social

Thrilled to share that Dr. Samaneh DiMartino, our amazing @nyctrainkuhr.bsky.social postdoc, has received an NIH/NIDDK F32 award to explore BCAA catabolism in AKI and fibrosis. Huge achievement—so proud of you, Sama!! @stonybrookmedicine.bsky.social

Had such an amazing time at the tri-lab joint BBQ to kick off summer! Loved sharing fun moments, delicious food, and building new connections with Dr. Dawlaty and Guo (@wenjunguolab.bsky.social) labs. Looking forward to more collaborations! @einsteinmededu.bsky.social @aysegulerdemm.bsky.social

Congrats Katherine @thekinglab.bsky.social and the team!

Congrats Rob @stonybrooku.bsky.social!

Huge congrats to Dr. Robert Bronstein @stonybrookmedicine.bsky.social, our @nyctrainkuhr.bsky.social postdoc and an expert in glomerulopathies, on being named a 2025 KidneyCure grantee! So well-deserved—an inspiring future leader in KUH field. So proud of you, Rob!! @einsteinmededu.bsky.social

Congrats Rob @stonybrooku.bsky.social!

Remembering James Till, 1931-2025 It has been 64 years since the publication of the classic 1961 Till & McCulloch paper that described spleen colonies in lethally irradiated mice following a bone marrow transplant [1]. On May 18, 2024...

Beautiful tribute to Dr. James Till by Dr. Norman Iscove. Truly honored to serve as editor for this legacy in @isehsociety.bsky.social, as a proud scientific descendant of Dr. McCulloch. Tx to Norman for insights into the early HSC era & Jim’s pivotal role. bit.ly/45NPeWb @einsteinmededu.bsky.social

New Medical Scientist Training Program students gather in front of bust of Albert Einstein at the Forchheimer Medical Science Building to take their group photo with program leader Myles Akabas.

New Medical Scientist Training Program students gather in front of bust of Albert Einstein at the Forchheimer Medical Science Building to take their group photo with program leader Myles Akabas.

New Medical Scientist Training Program students standing and seated at table at Forchheimer Medical Science Building.

New Medical Scientist Training Program students poses for her headshot at the Forchheimer Medical Science Building.

Welcome! Einstein’s newest M.D.-Ph.D. students in our Medical Scientist Training Program continued their orientation session Tuesday afternoon, gathering at the Forchheimer Medical Science Building to take their group photo with program leader Myles Akabas and their individual headshots.
#MedEd

Today is our Dr. Katrina Blankenhorn’s final SAC meeting before she starts as Clinical Asst Prof @stonybrooku.bsky.social. So proud of her ongoing dedication to clinical care & research in sickle cell disease & Pediatric HemOnc. Can’t wait to work together again, Katrina! @einsteinmededu.bsky.social

Continuing our interview spotlight series is the 2025 McCulloch and Till Awardee @steidluli.bsky.social‬ Dr. Steidl discusses his current work, career inspirations and more. Watch part III on www.simplyblood.org

Catching up with my @harvardmed.bsky.social postdoc buddies instantly takes me back! Had such a lovely dinner in New York with my close, same-age friends Shingo Kajimura @hhmi.org & Hiro Morishita @sinaibtain.bsky.social. So grateful for your inspiring science and a friendship that never changes!

Another heartfelt farewell to our collaborator Dr. Deepa Manwani, Dept of Pediatrics @einsteinmededu.bsky.social, as she heads to St. Jude (led by our friend Dr. Mitch Weiss) after years of dedicated care & research in sickle cell disease. We’ll miss you, Deepa—here’s to bridging Memphis & NY!

Bittersweet to see trainees move on, but so proud of our amazing Lidiane (Dr. Lidiane Torres) as she starts her next chapter! Your passion for neutrophil biology & sickle cell disease has inspired us all. Keep shining—we can’t wait for more chances to team up again! @einsteinmededu.bsky.social

Thanks to @lindemileslab.bsky.social and @challenlab.bsky.social (& team) for writing our first commentary for @isehsociety.bsky.social journal Experimental Hematology! Two recent papers on Clonal Hematopoiesis- want to learn more? Read the link here 👇🏻

Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations confer a fitness advantag...

Excited to see the first commentary in Experimental Hematology (@isehsociety.bsky.social)! Kudos to Aishwarya, Linde ‪@lindemileslab.bsky.social, and Grant @challenlab.bsky.social for highlighting recent papers in Exp Hem on cell-extrinsic factors in Tet2-mutant clonal hematopoiesis!! bit.ly/4k3pEAI

@nyctrainkuhr.bsky.social ‬team joined inspiring talks on mentoring & program growth, connected with other KUH training programs, and took part in mentor–mentee sessions. Huge thanks to ATLANTIS-KUH for the fantastic organization! #KUHRTN2025
@einsteinmededu.bsky.social @einsteincellbio.bsky.social

Our trainees had a truly enriching experience at #KUHRTN2025 at Emory, Atlanta! They gained insights into career development, received valuable advice, and enjoyed connecting with field leaders and peers from across the country. bit.ly/3H529IZ
@steidluli.bsky.social @gritsmanlab.bsky.social

Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival - Cancer & Metabolism Background Enhanced glycolysis plays a pivotal role in fueling the aberrant proliferation, survival and therapy resistance of acute myeloid leukemia (AML) cells. Here, we aimed to elucidate the extent...

New paper from our lab! In this study, we show that AML cells critically depend on LDHA to maintain their NAD+/NADH balance. Congrats to first author Ayşegül Erdem and all co-authors! cancerandmetabolism.biomedcentral.com/articles/10....

Had wonderful dinners with Dr. Jean-Emmanuel Sarry from CRCT-Oncopole, Toulouse! Loved his AML metabolism seminar at @einsteinmed.bsky.social’s Blood Cancer Institute, co-hosted by Drs. Will and Konopleva. Enjoyed the inspiring chats before and after. Excited to collaborate! @steidluli.bsky.social

Thank you so much, HemaSphere (@hemasphere-journal.bsky.social), for kind and warm words!

TET3 regulates hematopoietic stem cell homeostasis during embryonic and adult hematopoiesis The ten-eleven translocation family of enzymes (TET1/2/3) promotes DNA demethylation and is essential for hematopoiesis. While the roles of TET1 and TET2 are well-studied in hematopoiesis, the requir....

Our collaborative study with Dr. Meelad Dawlaty of @einsteinmededu.bsky.social is published in HemaSphere (@hemasphere-journal.bsky.social)! So excited that Harmony and Claudia’s teamwork uncovered the roles for TET3 in HSC homeostasis during embryonic and adult hematopoiesis!! bit.ly/3RQgFqf

Had a wonderful dinner with young Japanese researchers from @einsteinmededu.bsky.social and a guest clinical resident from Japan! Truly inspired and encouraged by all of you. Congrats on your amazing achievements—excited to see your continued growth and future successes!

Congrats, Stephanie @stephxie.bsky.social !!

So happy for you both, Kira and Jen (@trowbridgelab.bsky.social), and Steven Chan on the paper’s publication! Such a joy working with you and team. Claudia and I are thrilled to be part of this amazing study on mitochondrial activity in CH-mutant HSPCs! @einsteinmededu.bsky.social

Age-related blood condition counteracted with a common diabetes drug Metformin could reduce people’s risk of certain age-associated blood cancers, but more work is needed to identify who is likely to benefit.

New paper from my lab! Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis: rdcu.be/eh1Nb Complementary to new work from Steven Chan & @georgevassiliou.bsky.social as described by @goodell-lab.bsky.social: www.nature.com/articles/d41...

Congrats to Kira Young who spearheaded this work & all contributing authors. This was a fun (and long!) collaboration with @marcmansour.bsky.social, @challenlab.bsky.social, @ericpietras.bsky.social, Kelsey Fisher-Wellman, @keisukeito-lab.bsky.social & Steven Chan