Silvana Novelli

The $100 whole human genome sequence finally reached!
www.sandiegouniontribune.com/2026/02/19/s...

Read the first #PreprintWatch of 2026 which delves into healthy hematopoiesis, from the most immature stem cells to more committed progenitors. This issue also features community submissions from Constanze Bonifer, @boierslab.bsky.social and more➡️ iseh.org/Publications...

Selection of a Salvage Regimen for Relapsed or Refractory Classic Hodgkin Lymphoma in the Era of Novel Therapies - Hematology/Oncology Clinics www.hemonc.theclinics.com/article/S088...

CAP Aims to Improve Early Diagnosis of Amyloidosis With New Guideline The College of American Pathologists published a guideline for the laboratory workup of amyloidosis.

The @pathologists.bsky.social published a guideline for the laboratory workup of #amyloidosis in the Archives of Pathology & Laboratory Medicine.

https://bit.ly/496t2I9

Microbiota utilization of intestinal amino acids modulates cancer progression and anticancer immunity Qiao et al. identify gut microbes and amino acid-metabolizing genes that influence tumor burden. A Bacteroides asparaginase, bo-ansB, modulates host tumor responses to dietary asparagine (Asn) by depl...

Microbiota utilization of intestinal amino acids modulates cancer

Bacteroides asparaginase, bo-ansB, modulates host tumor responses to dietary asparagine by depleting Asn w/in TME. Reduced Asn impacts stemness of intratumoral CD8 T cells & tumor burden
www.cell.com/cell-host-mi...

CD8+ T-cell activation, function, and metabolic reprogramming are suppressed by hypoxia, linked to decreased mTOR activity. Read in Blood Advances: buff.ly/ttZb0at #BloodAdvances #MultipleMyeloma

Method of the Year: EM connectomics - Nature Methods Using electron microscopy, scientists mapped a Caenorhabditis elegans nervous system and Drosophila brain at single-neuron resolution. Connectomics work on bigger brains takes new methods strategies.

Method of the Year 2025: In her feature, @vivienm.bsky.social asks scientists about their strategies and decision-making as they scale EM-based approaches for larger brains.

www.nature.com/articles/s41...

Hans IHC discrimination of Cell-of-Origin Subtype is a valid method for predicting Polatuzumab response in DLBCL aacrjournals.org/clincancerre...

Should we start seeking clonal hematopoiesis before B-Cell Maturation Antigen–Directed Chimeric Antigen Receptor T-cell Therapy? aacrjournals.org/clincancerre...

#FoodInsecurity affects #healthcare workers too.

Efforts like #HCWvsHunger can help.

hcwvshunger.org

A new prognostic index (CLIPI) for advanced cutaneous lymphoma enables precise patient risk stratification Key PointsThere is poor survival in advanced stage MF/SS.CLIPI stratifies patients with advanced MF/SS into risk groups for survival and has been validated

Now it is imperative to include CLIPI in the routine evaluation of advanced stages Mycosis Fungoides & Sézary syndrome; especially when considering for alloSCT #ctcl

ashpublications.org/blood/articl...

Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial In this article by Robert Yeh and colleagues ( BMJ 2018;363:k5094, doi:10.1136/bmj.k5094), the final sentence of the Methods section should …

Reviewing this classic article @bmj.com

Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial

doi.org/10.1136/bmj....

I still teach it all the time

Our comprehensive Review on MGUS: Monoclonal Gammopathy of Undetermined Significance @NEJM

5% of people over age 50 have MGUS. Every physician needs to know and understand MGUS. Lots of Tables and Figures. www.nejm.org/doi/abs/10.1...

Lo mejor de escuchar a otros especialistas es cuando te encuentras con inmunólogas como la Dra. Silvia Vidal y te da una clase de #XPO #selinexor en el #mieloma
#Hemato2025 @sehhematologia.bsky.social

“Manejo periquirúrgico de los pacientes con coagulopatías adquiridas inmunológicas” con Eva Mingot, un enfoque práctico. @hospitaluvrocio.bsky.social @sehhematologia.bsky.social #Hemato2025

“Perfil molecular en la leucemia linfática crónica: más allá del TP53”. @ferrannadeu.bsky.social nos revela el universo de complejidad biológica de la #LLC @idibaps.bsky.social @sehhematologia.bsky.social #Hemato2025

Rafael de la Cámara nos revela la inmensa cantidad de fármacos antivirales en ensayo para mejorar el cuidado de nuestros pacientes. @sehhematologia.bsky.social #Hemato2025

CART de la Mano de Dr. Olalekan O. Oluwole - #Kite #hemato2025 @sehhematologia.bsky.social

Secuenciación de tercera generación en el diagnóstico hematológico. Dr. Javier Corral de la Calle repasando la evolución de la NGS. #hemato2025 @sehhematologia.bsky.social

Platelet transcriptomic-powered scientific discovery in Thrombosis and Hemostasis Dr. Matthew T. Rondina
Huntsman Cancer Institute & University of Utah Health,
Salt Lake City, Utah (USA). #sepsis #inflamación #hemato2025 ❤️

bleader.nmdp.org

The HLA-B Leader Assessment Tool (BLEAT) translates HLA-B leader matching based off of the research findings. doi.org/10.1016/S235...

“Selection of best donor in allogeneic stem cell transplantation: beyond HLA typing” por la Dra. Effie Wang Petersdorf #hemato2025 #educacional @sehhematologia.bsky.social

Es un lujo poder escuchar al Dr. Orfao hablando de la EMR en ls distintas neoplasias hematológicas #Hemato2025 @sehhematologia.bsky.social

Limited SUMOylation inhibitor administration enhances eradication of Burkitt’s lymphoma with CD19 CAR-T therapy Signal Transduction and Targeted Therapy - Limited SUMOylation inhibitor administration enhances eradication of Burkitt’s lymphoma with CD19 CAR-T therapy

Administration of SUMOylation inhibitor could eradicate #Burkitt’s #lymphoma treated with CD19 CAR-T.

rdcu.be/eJu9C

Reprogramming glutamine metabolism enhances BCMA-CART cell fitness and therapeutic efficacy in multiple myeloma Key Points. Glutamine deprivation in the tumor microenvironment might limit CAR T-cell therapeutic efficacy in cancer patients.ASCT2 overexpression improve

What a beautiful work from our colleagues from Navarra! @unav.edu #CUN
Increasing glutamine uptake may enhance anti-tumor BCMA-CAR T-cell functionality #MM

ashpublications.org/blood/articl...

A phase 2 trial of CHOP with anti-CCR4 antibody mogamulizumab for older patients with adult T-cell leukemia/lymphoma Key PointsMoga-CHOP significantly improved 1-year PFS in older patients with aggressive ATL.CCR4 mutations and Moga-associated cAEs were related to better

Improved PFS with Moga-Chop for elderly ATL patients. I wonder how the Moga
-Pembro would work in the same scenario 🧐
ashpublications.org/blood/articl...

🏁Avui #bcnhop #dansaurbana

www.barcelona.cat/barcelonacul...

🧠 Neurotoxicity in Cancer Therapy
New review (Nat Rev Clin Oncol)

✅ Pathophysiology of chemo-, RT- & IO-induced neurotoxicity
✅ Clinical recognition & biomarkers
✅ Prevention & management strategies

🔍 Key messages – Cavaletti, Cámara, DeAngelis et al. Nat Rev Clin Oncol 2025

WU Hoo! The Promise of Allogeneic WU-CART-007 in Relapsed/Refractory T-Cell Malignancies Ghobadi A, Aldoss I, Maude SL, . Phase 1/2 trial of anti-CD7 allogenic WU-CART-007 in patients with relapsed/refractory T-cell malignancies. Blood. Publish

WU Hoo! The Promise of Allogeneic WU-CART-007 in Relapsed/Refractory T-Cell Malignancies url: ashpublications.org/thehematolog...