Audald Lloret-Villas

🦣🧬🦣🤯💥We are pleased to share our new paper about ancient RNA expression profiles from the Woolly Mammoth, now published in Cell @cellpress.bsky.social

www.cell.com/cell/fulltex...

If you want to know more, read the 🧵 below:

"Franklin was an equal member in a group of four scientists [...] recognized by her colleagues as such, although that acknowledgement was both belated and understated [...] deserves to be remembered not as the victim of the double helix, but as an equal contributor to the solution of the structure."

"it was not a case of them stealing the King’s group’s data and then, voila, those data gave them the structure of DNA. Instead, they solved the structure through their own iterative approach and then used the King’s data — without permission — to confirm it."

What a course!🧬🦣

Thanks to this amazing team of instructors @claudiafontsere.bsky.social @jazminrm.bsky.social & @hernmoral.bsky.social for delivering such a great first edition of the #Museomics course.
Thanks to everyone who has joined us this week and good luck with your data!💯

New Zealand’s invasive starlings on the cover of Molecular Ecology! 🐦🧬

This collaborative project unpacks the invasion history of starlings in Aotearoa New Zealand, combining population genomics with historical records of human-mediated translocations.

onlinelibrary.wiley.com/doi/10.1111/...

Our monthly #EPIC seminars are back! 🎉
This month, Thomas Bøggild kicked things off with a fascinating talk on stopped recombination in new sex chromosomes, and @audald.bsky.social followed with great insights into recombination maps and imputation in #PopGen studies.
See you next month!

Q&A: inbreeding and its implications for conservation - BMC Biology Inbreeding depression plays a role in the decline, endangerment, and extinction of small populations, and thus inbreeding has received much attention in conservation biology. The term inbreeding is us...

Our Q&A article on inbreeding for conservation is out in BMC Biology!

We discuss some important key concepts related to inbreeding in the light of new genomic tools and what it means for conservation when we want to improve species survival.

#consgen

bmcbiol.biomedcentral.com/articles/10....

Un tipo llamado Fred Sanger - Gen-Ética Este verano hemos pasado unos días en Cambridge (Reino Unido), ciudad universitaria por excelencia y sede de prestigiosos e históricos centros de investigación. Estos centros convierten a Cambridge en...

Este verano visitamos Cambridge, con su universidad y centros de investigación referentes en biología molecular. Donde trabajó Fred Sanger, ganador de 2 premios Nobel de Química. Un investigador singular e irrepetible. Te lo explico en mi blog @naukas.bsky.social
montoliu.naukas.com/2025/08/24/u...

GitHub - vibaotram/simulation Contribute to vibaotram/simulation development by creating an account on GitHub.

💡 Bonus: Open Snakemake pipelines for both simulation and imputation are provided:
- github.com/vibaotram/si...
- github.com/vibaotram/im...

Feel free to test and optimize imputation strategies for your own datasets before committing to large-scale LCS projects.

💥 Downstream impact:
- PopGen analyses (relatedness, population structure) were congruent with imputation accuracy and depend on genetic relatedness.
- Inbreeding coefficient estimates were more sensitive to imputation.
- Demographic analysis on imputed data showed similar results across the tools.

🔑 Choosing your imputation tool:
- All tools worked well in highly related populations.
- Accuracy varied in populations with low relatedness, but GLIMPSE2 & QUILT2 generally outperformed the other tools.
- STITCH is useful when no reference panel exists but results in some missing data.

👩🏻‍💻 We tested 5️⃣ imputation methods (GLIMPSE2, GeneImp, QUILT2, STITCH, Beagle5.4), simulated realistic populations with different genetic structures, and applied the methods to data from 283 wild hihi (stitchbird) 🧬.

Assessing Genotype Imputation Methods for Low‐Coverage Sequencing Data in Populations With Differing Relatedness and Inbreeding Levels Low-coverage sequencing (LCS) followed by genotype imputation has become a cost-efficient approach for obtaining whole-genome SNPs. Several imputation methods for LCS data have been developed over th....

We explored that in this new study in Molecular Ecology Resources 🔎

onlinelibrary.wiley.com/doi/10.1111/...

@vbtram.bsky.social
@huizhentan.bsky.social
@katarinastuart.bsky.social
@annasanture.bsky.social

Low-coverage sequencing (LCS) + genotype imputation is a cost-effective approach to genotype hundreds of samples at a full-genome level. But how do different imputation tools perform across populations with varying relatedness and inbreeding?

A male New Zealand Falcon perched on a branch at Zealandia wildlife sanctuary. Wellington, New Zealand

Aotearoa, meet your 2025 Bird of the Year 👑🦅

The kārearea or New Zealand falcon is our only species of falcon, and has reclaimed the top spot once again after its last victory in 2012 🏆

Learn more about this endemic bird of prey ⬇️
w.wiki/FUGN

📷: Tony Wills, CC BY-SA 3.0 #BirdOfTheYear

Postdoctoral Fellowship in Water Buffalo Population Genomics The Department of Biology, Faculty of Science at University of Copenhagen is offering a post doc position to work on population genomic analyses in water buffal

UCPH seeks a postdoc in Water Buffalo Population Genomics, starting Jan 2026. Applicants need a PhD in related fields, programming skills, & experience with… https://candidate.hr-manager.net/ApplicationInit.aspx/?cid=1307&departmentId=18965&ProjectId=164930&MediaId=5&SkipAdvertisement=false #postdoc

Scientists, DON'T USE LaTeX UNLESS ABSOLUTELY NECESSARY, DON'T GIVE LaTeX TO YOUR YOUNG CHILD FOR VIRTUALLY ANY REASON, BREAK UP THE .tex DOC INTO THREE TOTALLY SEPARATE DOCS (NOT MIXED!), TAKE [Underfull \vbox (badness 10000) has occurred]

YouTube video by SciShow These Birds Aren’t Real

Nice SciShow-video with many examples of studies using "fake birds" (i.e. decoys or dummies). #ornithology
www.youtube.com/watch?v=aSzC...

☀️ My Mediterranean summer has come to an end, and today I’m kicking off a new postdoctoral adventure in @hernmoral.bsky.social’s group at the Globe Institute! Lots to learn, lots to contribute, and hopefully lots more posting here about Evolutionary & Conservation Genomics 🚀

🦣🍖🧬 Fully funded 3-yr PhD in palaeogenomics & bioinformatics! Help me push non-model palaeogenomes beyond their limits @DTU in Denmark.

Start: Feb 2026 (flexible)
Application deadline: 24 Oct 2025

For details click here: tinyurl.com/BioExtPhD

Reposts appreciated 😁

1/10 We are thrilled to announce that our new paper on conservation genomics of the Balearic shearwater has just been published online at @pnas.org! www.pnas.org/doi/10.1073/...

High Imputation Accuracy Can Be Achieved Using a Small Reference Panel in a Natural Population With Low Genetic Diversity Genotype imputation, the inference of missing genotypes using a reference set of population haplotypes, is a cost-effective tool for improving the quality and quantity of genetic datasets. Imputation...

Genomic imputation can boost dataset quality and benefit research on wild populations. In hihi, we found high #imputation accuracies despite a small reference panel of high-fecundity individuals. Imputation improves downstream #ConservationGenomics analyses. onlinelibrary.wiley.com/doi/10.1111/...

Me promoting the Genomic History Inference Strategies Tournament at #eseb2025! ghi.st
Population geneticists: join, compete, earn cash, become an author, learn, help the community! ghi.st

Will be presenting our work on imputation of lcWGS in populations with a range of relatedness and inbreeding. Find me throughout the day at #ESEB2025 (board 337)

Dr. Tram Vi, @annasanture.bsky.social and colleagues (@aucklanduni.bsky.social)

Back home for a good reason 💁🏻‍♂️
#ESEB2025

Dr. Tram Vi presented yesterday her fantastic work on imputation of lcWGS in population analyses, in which I had the chance to participate (w/ @annasanture.bsky.social and colleagues). #GSA2025

I had the chance to talk about this work (part of my postdoc in @susanneppfeifer.bsky.social’ group) at #GSA2025

As seen in @huizhentan.bsky.social’ presentation - all credit to her!

The actual PopGen Power Rangers were revealed at the #GSA2025

First chilly jog in Tāmaki Makaurau / Auckland and ready for the #GSA2025 - @geneticsaus.bsky.social