Audald Lloret-Villas

Un tipo llamado Fred Sanger - Gen-Ética Este verano hemos pasado unos días en Cambridge (Reino Unido), ciudad universitaria por excelencia y sede de prestigiosos e históricos centros de investigación. Estos centros convierten a Cambridge en...

Este verano visitamos Cambridge, con su universidad y centros de investigación referentes en biología molecular. Donde trabajó Fred Sanger, ganador de 2 premios Nobel de Química. Un investigador singular e irrepetible. Te lo explico en mi blog @naukas.bsky.social
montoliu.naukas.com/2025/08/24/u...

GitHub - vibaotram/simulation Contribute to vibaotram/simulation development by creating an account on GitHub.

💡 Bonus: Open Snakemake pipelines for both simulation and imputation are provided:
- github.com/vibaotram/si...
- github.com/vibaotram/im...

Feel free to test and optimize imputation strategies for your own datasets before committing to large-scale LCS projects.

💥 Downstream impact:
- PopGen analyses (relatedness, population structure) were congruent with imputation accuracy and depend on genetic relatedness.
- Inbreeding coefficient estimates were more sensitive to imputation.
- Demographic analysis on imputed data showed similar results across the tools.

🔑 Choosing your imputation tool:
- All tools worked well in highly related populations.
- Accuracy varied in populations with low relatedness, but GLIMPSE2 & QUILT2 generally outperformed the other tools.
- STITCH is useful when no reference panel exists but results in some missing data.

👩🏻‍💻 We tested 5️⃣ imputation methods (GLIMPSE2, GeneImp, QUILT2, STITCH, Beagle5.4), simulated realistic populations with different genetic structures, and applied the methods to data from 283 wild hihi (stitchbird) 🧬.

Assessing Genotype Imputation Methods for Low‐Coverage Sequencing Data in Populations With Differing Relatedness and Inbreeding Levels Low-coverage sequencing (LCS) followed by genotype imputation has become a cost-efficient approach for obtaining whole-genome SNPs. Several imputation methods for LCS data have been developed over th....

We explored that in this new study in Molecular Ecology Resources 🔎

onlinelibrary.wiley.com/doi/10.1111/...

@vbtram.bsky.social
@huizhentan.bsky.social
@katarinastuart.bsky.social
@annasanture.bsky.social

Low-coverage sequencing (LCS) + genotype imputation is a cost-effective approach to genotype hundreds of samples at a full-genome level. But how do different imputation tools perform across populations with varying relatedness and inbreeding?

A male New Zealand Falcon perched on a branch at Zealandia wildlife sanctuary. Wellington, New Zealand

Aotearoa, meet your 2025 Bird of the Year 👑🦅

The kārearea or New Zealand falcon is our only species of falcon, and has reclaimed the top spot once again after its last victory in 2012 🏆

Learn more about this endemic bird of prey ⬇️
w.wiki/FUGN

📷: Tony Wills, CC BY-SA 3.0 #BirdOfTheYear

Postdoctoral Fellowship in Water Buffalo Population Genomics The Department of Biology, Faculty of Science at University of Copenhagen is offering a post doc position to work on population genomic analyses in water buffal

UCPH seeks a postdoc in Water Buffalo Population Genomics, starting Jan 2026. Applicants need a PhD in related fields, programming skills, & experience with… https://candidate.hr-manager.net/ApplicationInit.aspx/?cid=1307&departmentId=18965&ProjectId=164930&MediaId=5&SkipAdvertisement=false #postdoc

Scientists, DON'T USE LaTeX UNLESS ABSOLUTELY NECESSARY, DON'T GIVE LaTeX TO YOUR YOUNG CHILD FOR VIRTUALLY ANY REASON, BREAK UP THE .tex DOC INTO THREE TOTALLY SEPARATE DOCS (NOT MIXED!), TAKE [Underfull \vbox (badness 10000) has occurred]

YouTube video by SciShow These Birds Aren’t Real

Nice SciShow-video with many examples of studies using "fake birds" (i.e. decoys or dummies). #ornithology
www.youtube.com/watch?v=aSzC...

☀️ My Mediterranean summer has come to an end, and today I’m kicking off a new postdoctoral adventure in @hernmoral.bsky.social’s group at the Globe Institute! Lots to learn, lots to contribute, and hopefully lots more posting here about Evolutionary & Conservation Genomics 🚀

🦣🍖🧬 Fully funded 3-yr PhD in palaeogenomics & bioinformatics! Help me push non-model palaeogenomes beyond their limits @DTU in Denmark.

Start: Feb 2026 (flexible)
Application deadline: 24 Oct 2025

For details click here: tinyurl.com/BioExtPhD

Reposts appreciated 😁

1/10 We are thrilled to announce that our new paper on conservation genomics of the Balearic shearwater has just been published online at @pnas.org! www.pnas.org/doi/10.1073/...

High Imputation Accuracy Can Be Achieved Using a Small Reference Panel in a Natural Population With Low Genetic Diversity Genotype imputation, the inference of missing genotypes using a reference set of population haplotypes, is a cost-effective tool for improving the quality and quantity of genetic datasets. Imputation...

Genomic imputation can boost dataset quality and benefit research on wild populations. In hihi, we found high #imputation accuracies despite a small reference panel of high-fecundity individuals. Imputation improves downstream #ConservationGenomics analyses. onlinelibrary.wiley.com/doi/10.1111/...

Me promoting the Genomic History Inference Strategies Tournament at #eseb2025! ghi.st
Population geneticists: join, compete, earn cash, become an author, learn, help the community! ghi.st

Will be presenting our work on imputation of lcWGS in populations with a range of relatedness and inbreeding. Find me throughout the day at #ESEB2025 (board 337)

Dr. Tram Vi, @annasanture.bsky.social and colleagues (@aucklanduni.bsky.social)

Back home for a good reason 💁🏻‍♂️
#ESEB2025

Dr. Tram Vi presented yesterday her fantastic work on imputation of lcWGS in population analyses, in which I had the chance to participate (w/ @annasanture.bsky.social and colleagues). #GSA2025

I had the chance to talk about this work (part of my postdoc in @susanneppfeifer.bsky.social’ group) at #GSA2025

As seen in @huizhentan.bsky.social’ presentation - all credit to her!

The actual PopGen Power Rangers were revealed at the #GSA2025

First chilly jog in Tāmaki Makaurau / Auckland and ready for the #GSA2025 - @geneticsaus.bsky.social

Just three more sleeps until #GSA2025 kicks off in Tāmaki Makaurau/Auckland!

Bring your love of science, your curiosity, and maybe a rain jacket - just in case 🌧️🧬

We can't wait to see you there!

✍ New blog post: The World Is Falling Apart, But You Don't Have To Follow
jenteottenburghs.wordpress.com/2025/05/19/t...

SIBE summer school SIBE SUMMER SCHOOL 2025 7th − 11th September 2025 FERRARA (ITALY) Overview The analysis of genomic data has become increasingly feasible, even in non-model organisms, thanks to the “omics” revolution...

I'll be teaching in the SIBE Summer School in Ferrara, from the 7th to 11th of September.
Great place to learn about PopGen, comparative genomics and ✨Conservation Genomics✨
🚨Deadline to apply: 11th of May🚨
sites.google.com/view/sibesum...

See you there!

CJ Versoza @susanneppfeifer.bsky.social @audald.bsky.social & JD Jensen use WGS of pedigrees of aye-ayes to map crossover and noncrossover recombination events.

🔗 doi.org/10.1093/gbe/evaf072

#genome #primate #recombination #evolution

A graphic for the Marie Skłodowska-Curie Actions (MSCA), showing a historical portrait of Marie Skłodowska-Curie overlaid with an image of four young researchers walking down a hallway. The European Commission logo is in the top left. Text reads: "Marie Skłodowska-Curie Actions – €404.3 million to support postdoctoral researchers”

Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF

Already 30+ registered for our 7th #bioinformatics #hackathon
@bcmhgsc.bsky.social
around Structural Variants, Graph genomes & many related topics: fritzsedlazeck.github.io/blog/2025/ha...
Groups will work on interesting topics that will be published in F1000.

Registration till 10th of Aug!

Lovely spring day in Tucson, enjoying many exciting talks at the #AZPopGroup, moderated by @ryangutenkunst.bsky.social.