Nils Kroemer

Sneak peek of an inset of the results figures from our diffusion basis spectrum imaging data.

I am enjoying a few uninterrupted hours of plotting today. Finally got my hands on our diffusion basis spectrum imaging data, and it looks good, particularly in white matter voxels. I hope we will have a preprint coming out in a few weeks, led by @lhkal.bsky.social & @akuehnel.bsky.social

New paper in Imaging Neuroscience by Timo Hofsähs, Petra Ritter, et al:

The Virtual Brain links transcranial magnetic stimulation evoked potentials and inhibitory neurotransmitter changes in major depressive disorder

doi.org/10.1162/IMAG...

fMRI connectivity is dominated by recurring high-amplitude BOLD events (CAPs, QPPs)
But what originates these events? Many think neuromodulation is the culprit. Our new work offers a simpler take: cortico-cortical dynamics alone can generate CAP-like events! doi.org/10.1371/journal.pcbi.1013995
🧵1/n

The wonderful historic city of Marburg

🚨 University Marburg (Germany) is recruiting a W2 Professor of Mol. Pharmacology in the Faculty of Medicine.

Focus areas: Epithelial adaptation in #inflammation, #regeneration, and/or #cancer

stellenangebote.uni-marburg.de/jobposting/0...

#AcademicJobs #Pharmacology #FacultyPosition #cellbio

BahnBet — Bet on German Train Delays Predict Deutsche Bahn delays and win. Real-time prediction markets on ICE, IC & EC train delays.

What I thought was a joke is real: you can now bet on German train delays. bahn.bet

🚨Preprint! “Bayesian surprise tracks the strength of perceptual insight” - Work with @lindedomingo.bsky.social & @gonzalezgarcia.bsky.social

Ever wondered what factors influence the subjective experience of suddenly understanding a previously unclear input?

Click below:
doi.org/10.64898/202...

A crowdsourced megastudy of 12 digital single-session interventions for depression in US adults Nature Human Behaviour - An online experiment compared 12 brief online interventions for depression. Most improved mental health immediately, but these gains decreased over time, with only two...

Our crowdsourced megastudy comparing a diverse set of 12 single-session interventions for depression is out today in @nathumbehav.nature.com!

Read the full paper here: rdcu.be/e6pzz (no paywall)

We also published a brief non-academic piece about the study today: theconversation.com/free-10-minu...

Striatum-wide dopamine encodes trajectory errors separated from value - Nature Cue-evoked striatal dopamine release in mice encodes bidirectional trajectory errors, spatially and temporally separated from value coding, reflecting the relationship between the speed and direc...

Striatum-wide dopamine encodes trajectory errors separated from value
www.nature.com/articles/s41...
#neuroscience

Parieto-occipital ERP indicators of gut mechanosensation in humans - Nature Communications Understanding the neural processes governing the human gut-brain connection has been challenging. Here, the authors investigate the perceptual response and neural correlates of gastrointestinal sensat...

For gastric interoception, I like the smart/vibrating pill studies as examples:
www.nature.com/articles/s41...

elifesciences.org/articles/85567

I’m currently redesigning my Body–Brain–Emotion seminar for our General Psychology MSc students. Last year, we covered the spectrum from basic sensory processes to perception (e.g., cardiac effects), as well as breathing and sleep, gut-brain interaction.

As body-augmenting technologies become more common, it is important to understand how the brain decides what counts as "the body", and how that changes over time.

My first postdoc paper 🦾 now out in @elife.bsky.social 👇

a person is putting a coin into a machine that says loser on it ALT: a person is putting a coin into a machine that says loser on it

Another fun story about the current grant situation. I applied for a modest sum in response to a call from a foundation. Apparently, they received more than 1000 applications, and they award only a few per call, so the funding rate is lower than 1%.

That's true, and I am sorry to hear that. I wish there was a more streamlined process for resubmissions because this would also save scarce resources, especially if the initial review round only asks for minor revisions.

Yeah, still under review, so at least the second is still missing. This is the first time it has taken so long for one of my grants, but I heard similar stories from others. I am just waiting for the reviewer to complain that it lacks the most recent references 🫠.

a birthday cupcake with a pink candle and sprinkles on it ALT: a birthday cupcake with a pink candle and sprinkles on it

Happy birthday!

I can't believe it's already been 12 months since I submitted my beautiful grant, and the reviews are still not in. Is this the slow science everyone is talking about?

Remodeling of human diurnal adipose tissue transcriptome by the composition of morning and afternoon meals Circadian clocks orchestrate metabolic processes in the whole body and their response to food. Therefore, not only what and how much, but also when we…

@dzg-forschen.bsky.social
🕒 How the timing of carbs + fats shapes metabolic health
The timing of macronutrient intake significantly reshapes gene activity in adipose tissue. Chrononutrition may help reduce metabolic dysfunction and inflammation linked to #obesity and #diabetes.➡️https://t1p.de/kqny0

Simulated trait distributions for two groups with different shapes. Top left: distinct skewness. Top right: distinct kurtosis. Bottom: different correlations between two traits for two groups.

Differences between M & F are pervasive, but we often focus on #SexDifferences in the mean. @pietropollo.bsky.social @danielwanoble.bsky.social @itchyshin.bsky.social &co present #stats tools that allow comparison of #skewness, #kurtosis & correlations b'n groups @plosbiology.org 🧪 plos.io/4093nJs

Thrilled to finally share this work! 🧠🔊

Using a new reinforcement-free task we show mice (like humans) extract abstract structure from sound (unsupervised) & dCA1 is causally required by building factorised, orthogonal subspaces of abstract rules.

Led by Dammy Onih!
www.biorxiv.org/content/10.6...

Abdominal ultrasound activates afferent vagal signaling and central autonomic pathways.

Abdominal ultrasound activates afferent vagal fibers and suppresses systemic inflammation.
This 🤯 paper has many interesting findings, including increased c-Fos expression in the NTS, confirming central activation. #neuroskyence 🩺
Work by Shimoyama et al., PNAS
www.pnas.org/doi/abs/10.1...

Duration between rewards controls the rate of behavioral and dopaminergic learning - Nature Neuroscience Cue–reward learning rate scales proportionally with the time between rewards. Consequently, learning over a fixed duration is independent of the number of trials. This challenges trial-based dopamine ...

Very excited to post our paper led by @daburke.bsky.social www.nature.com/articles/s41... where we uncover a simple mathematical rule underlying how brains learn that a cue predicts a reward. 1/26

🧠🏃 New in Neuron (open access): “Exercise-induced activation of VMH SF1 neurons mediates improvements in endurance”

Finally able to share what we learned about the brain & exercise 🧵

New neuromapr #rstats package is available from GitHub! Highly experimental, early adopters and bug identifiers are super welcome to report issues!

github.com/lcbc-uio/neu...

#neuroscience #rstats #neuroimaging

📣 NEW! I’ve just released the BIGGEST and perhaps most creative project I’ve ever worked on!

“Searching for Birds” searchingforbirds.visualcinnamon.com 🐤

A project, an article, an exploration that dives into the data that connects humans with birds, by looking at how we search for birds.

Wow, congratulations, Lina 👏!

Subcomponents of reward processing in adolescent anhedonia Nature Reviews Psychology - Understanding the link between anhedonia and reward processing in adolescence can enhance mental health interventions specifically for young people. In this Review, Ma...

Excited to share our new review on #adolescent #anhedonia and #reward processing, published in
@NatRevPsych
with my lab @XueqingMa @AngadSahni9
rdcu.be/e2ENh
bsky.app/profile/unir...

👀

Prefrontal neural geometry of learned cues guides motivated behaviours - Nature The dorsomedial prefrontal cortex encodes the value, salience and valence of learned stimuli along distinct neural dimensions, and the geometry of these representations shapes motivated behaviours in ...

Can you easily distinguish between value, valence, and salience?

Probably not, but the prefrontal cortex of mice seems to achieve this by creating a sort of multidimensional orthogonal neural space, where each dimension corresponds to one of these subjective elements

www.nature.com/articles/s41...

Dark blue hexagon, with a light blue frame. Features a brain facing the left, with the front half as a wire-frame mesh of light blue, and the back half with several polygon segments of different colours. Below is written "ggseg" in light blue.

The ggseg ecosystem finally has a proper home! 🧠

For those who don't know, ggseg is an R package ecosystem for visualizing brain atlas data. Think ggplot2, but for brains.

#rstats #neuroimaging #openscience

Breakthrough @nature.com study showcases new non-invasive treatment for Parkinson’s Disease that targets the somato-cognitive action network (SCAN) with personalized neuromodulation, for superior outcomes. www.nature.com/articles/s41...