Markku Hakala's Avatar

Markku Hakala

@mhakala.bsky.social

Protein, membranes and their interplay. Group Leader at University of Helsinki in ๐Ÿ‡ซ๐Ÿ‡ฎ. Former postdoc at UNIGE ๐Ÿ‡จ๐Ÿ‡ญin @rouxlab.bsky.social and @kaksonen.bsky.social labs. I like bicycling, hiking, skiing, climbing and sour things.

994 Followers  |  861 Following  |  102 Posts  |  Joined: 20.09.2023
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Posts by Markku Hakala (@mhakala.bsky.social)


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Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028

๐Ÿšจ Job Alert! ๐Ÿšจ

We have an opening at our Microscopy Core Facility in Turku ๐Ÿ‡ซ๐Ÿ‡ฎ.
If you love imaging ๐Ÿ”ฌ and helping scientists succeed, we want you! ๐Ÿ‘‡

abo.rekrytointi.com/paikat/index...

#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social

15.01.2026 14:04 โ€” ๐Ÿ‘ 48    ๐Ÿ” 74    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 2

Early bird deadline in 10 days!! This is going to be amazing!

06.01.2026 19:12 โ€” ๐Ÿ‘ 8    ๐Ÿ” 10    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

I will be recruiting two postdocs early next year.
- One image analyst
- one biologist interested in working on lymphatics!

Reach out if you are interested ๐Ÿ‘

21.12.2025 08:58 โ€” ๐Ÿ‘ 54    ๐Ÿ” 43    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
copyright Palina Nepachalovich of ZML Dresden

copyright Palina Nepachalovich of ZML Dresden

Ups we did it again! Please mark your calender. EMBO Workshop โ€œLipid Code to Lifeโ€, taking place September 7โ€“11, 2026, in Dresden, organized by Maria Fedorova, @lipid.bsky.social, Valerie O'Donnell, @holthuislab.bsky.social and @molcellbiophys-lab.bsky.social ๐Ÿฅณ Retweets = lipidlove

15.12.2025 14:36 โ€” ๐Ÿ‘ 44    ๐Ÿ” 37    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1

๐Ÿ’ฅI am excited to present our first research paper from the lab about caveolae lipid trafficking ๐ŸŽ‰ Led by my fantastic PhD candidate @estherocket.bsky.social

Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated ๐Ÿ‘‡ 1/n

11.12.2025 07:08 โ€” ๐Ÿ‘ 44    ๐Ÿ” 17    ๐Ÿ’ฌ 6    ๐Ÿ“Œ 0
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Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism The emergence of cell compartmentalization depends on membrane fission to create the endomembrane compartments. In eukaryotes, membrane fission is commonly executed by ESCRT-III, a protein complex con...

New preprint from the lab!!๐ŸŽ‰
We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...

01.12.2025 09:09 โ€” ๐Ÿ‘ 81    ๐Ÿ” 32    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 9
Main - Cell Dynamics and Fragmentation Lab The Cell Dynamics and Fragmentation lab at We study how single cells move and fragment in complex environments using microfluidics. We bring tools and concep...

Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!

11.11.2025 17:10 โ€” ๐Ÿ‘ 73    ๐Ÿ” 35    ๐Ÿ’ฌ 14    ๐Ÿ“Œ 1

Watch out folks, I donโ€™t wanna alarm anyone, but good news is possible!!

12.11.2025 14:43 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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๐Ÿ“ขElectron Microscopy Unit, Helsinki BioImaging, and ZEISS are organizing a symposium "Frontiers in Imaging: celebrating the EMBI-ZEISS partnership on volumeEM"
๐Ÿ—“๏ธDecember 2-3, 2025
๐Ÿ“Institute of Biotechnology, University of Helsinki
๐Ÿ”—Program and registration linkโคต๏ธ
www.helsinki.fi/en/infrastru...

10.11.2025 10:49 โ€” ๐Ÿ‘ 5    ๐Ÿ” 4    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. Weย analyzeย thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...

06.11.2025 07:38 โ€” ๐Ÿ‘ 82    ๐Ÿ” 30    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 6

If you are planning to do Flipper-TR experiments or FLIM imaging in general, I strongly recommend reading this beautiful method paper first! Lots of information about optimal data acquisition for reliable data analysis! Nice work from Tithi, @rouxlab.bsky.social and @juanmagararc.bsky.social !

22.10.2025 08:54 โ€” ๐Ÿ‘ 5    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

๐ŸŒŸ Thrilled to share that my labโ€™s first publication is now out in @natmetabolism.nature.com. Congrats to the team ๐ŸŽ‰

๐Ÿง  We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3

01.10.2025 04:11 โ€” ๐Ÿ‘ 45    ๐Ÿ” 21    ๐Ÿ’ฌ 4    ๐Ÿ“Œ 1
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Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging

www.biozentrum.unibas.ch/open-positio...

#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

29.09.2025 14:58 โ€” ๐Ÿ‘ 49    ๐Ÿ” 52    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 5

Join us for the first @embo.org meeting on Intracellular mechanics and organelle mechanobiology! Registrations are open, submit your abstract by November 14: we have plenty of slots for short talks! #EMBOMechanobio

29.09.2025 18:12 โ€” ๐Ÿ‘ 10    ๐Ÿ” 7    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Research Assistant or Master Thesis worker, group Hakala Research Assistant or Master Thesis worker, group Hakala

Undergraduate/internship/master's thesis position: jobs.helsinki.fi/job-invite/4...

29.09.2025 15:45 โ€” ๐Ÿ‘ 4    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Doctoral Researcher, group Hakala Doctoral Researcher, group Hakala

PhD student position: jobs.helsinki.fi/job-invite/4...

29.09.2025 15:45 โ€” ๐Ÿ‘ 4    ๐Ÿ” 3    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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I have a PhD student and an undergrad student positions open at the Institute of Biotechnology @helsinki.fi We are using reconstitution, cell and structural biology to study protein-membrane interactions and membrane microdomain formation. Links to calls below! Feel free to drop a message and share!

29.09.2025 15:45 โ€” ๐Ÿ‘ 11    ๐Ÿ” 6    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0

Halfway to I2K is BACK, friends of all kinds! Last year, 650 people attended 30+ TOTALLY FREE image analysis workshops of all kinds, across many timezones.

If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.

23.09.2025 15:48 โ€” ๐Ÿ‘ 50    ๐Ÿ” 33    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 2
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Tiny Tubes Reveal Clues to the Evolution of Complex Life | Quanta Magazine Scientists have identified tubulin structures in primitive Asgard archea that may have been the precursor of our own cellular skeletons.

Story on our Asgard microtubule paper by Nikki Greenwood: www.quantamagazine.org/tiny-tubes-r...
Thanks to all interviewees๐ŸŽค

10.09.2025 07:07 โ€” ๐Ÿ‘ 36    ๐Ÿ” 13    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

For all of you #Actin folks ... It's out !
Happy to help at anypoint

10.09.2025 09:11 โ€” ๐Ÿ‘ 27    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

A new #UExM probe for #Actin!

Fun times thinking/developing/testing with @centriolelab.bsky.social & @lreymond.bsky.social !

Congrats to all !

If interested in #UExM, or #HAK-Actin, feel free to reach out !

Soon available at @spirochrome.com

#Expansion #Microscopy #ProtistsOnSky

28.08.2025 07:16 โ€” ๐Ÿ‘ 45    ๐Ÿ” 19    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 0

Postdoc program at the MDC in Berlin, @mdc-berlin.bsky.social : take a look ๐Ÿ‘‡๐Ÿ‘‡

For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!

www.mdc-berlin.de/postdocs#t-g...

04.08.2025 10:23 โ€” ๐Ÿ‘ 11    ๐Ÿ” 8    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Suomen Akatemian LinkedIn-pรคivitys: 

The Research Council of Finland firmly condemns the harassment and hate speech that RCF-funded researchers have recently faced online.
ย 
This kind of targeting behaviour is highly inappropriate and dangerous. It threatens academic freedom, narrows public debate, and undermines trust in science and the people behind it.
ย 
๐—œ๐—ป ๐—™๐—ถ๐—ป๐—น๐—ฎ๐—ป๐—ฑ, ๐—ฎ๐—ฐ๐—ฎ๐—ฑ๐—ฒ๐—บ๐—ถ๐—ฐ ๐—ณ๐—ฟ๐—ฒ๐—ฒ๐—ฑ๐—ผ๐—บ ๐—ถ๐˜€ ๐—ฎ ๐—ฐ๐—ผ๐—ฟ๐—ฒ ๐˜ƒ๐—ฎ๐—น๐˜‚๐—ฒ. Researchers must be able to explore, question and share knowledge openly. The RCF funds research through open competition and international peer review, and our staff work to ensure the ๐—ถ๐—ป๐˜๐—ฒ๐—ด๐—ฟ๐—ถ๐˜๐˜† ๐—ฎ๐—ป๐—ฑ ๐—ณ๐—ฎ๐—ถ๐—ฟ๐—ป๐—ฒ๐˜€๐˜€ of the process.
ย 
Debate and disagreement are part of a healthy democracy. But there is a line that is crossed when the conversation turns into personal attacks or intimidation.
ย 
We call on everyone to help keep that line clear. ๐—Ÿ๐—ฒ๐˜โ€™๐˜€ ๐—ฝ๐—ฟ๐—ผ๐˜๐—ฒ๐—ฐ๐˜ ๐˜๐—ต๐—ฒ ๐—ณ๐—ฟ๐—ฒ๐—ฒ๐—ฑ๐—ผ๐—บ ๐˜๐—ผ ๐—ฑ๐—ผ ๐˜€๐—ฐ๐—ถ๐—ฒ๐—ป๐—ฐ๐—ฒ, and the people who make it possible.

In 2023, we released a statement on the online targeting of researchers: https://lnkd.in/dbRrUDBu

Suomen Akatemian LinkedIn-pรคivitys: The Research Council of Finland firmly condemns the harassment and hate speech that RCF-funded researchers have recently faced online. ย  This kind of targeting behaviour is highly inappropriate and dangerous. It threatens academic freedom, narrows public debate, and undermines trust in science and the people behind it. ย  ๐—œ๐—ป ๐—™๐—ถ๐—ป๐—น๐—ฎ๐—ป๐—ฑ, ๐—ฎ๐—ฐ๐—ฎ๐—ฑ๐—ฒ๐—บ๐—ถ๐—ฐ ๐—ณ๐—ฟ๐—ฒ๐—ฒ๐—ฑ๐—ผ๐—บ ๐—ถ๐˜€ ๐—ฎ ๐—ฐ๐—ผ๐—ฟ๐—ฒ ๐˜ƒ๐—ฎ๐—น๐˜‚๐—ฒ. Researchers must be able to explore, question and share knowledge openly. The RCF funds research through open competition and international peer review, and our staff work to ensure the ๐—ถ๐—ป๐˜๐—ฒ๐—ด๐—ฟ๐—ถ๐˜๐˜† ๐—ฎ๐—ป๐—ฑ ๐—ณ๐—ฎ๐—ถ๐—ฟ๐—ป๐—ฒ๐˜€๐˜€ of the process. ย  Debate and disagreement are part of a healthy democracy. But there is a line that is crossed when the conversation turns into personal attacks or intimidation. ย  We call on everyone to help keep that line clear. ๐—Ÿ๐—ฒ๐˜โ€™๐˜€ ๐—ฝ๐—ฟ๐—ผ๐˜๐—ฒ๐—ฐ๐˜ ๐˜๐—ต๐—ฒ ๐—ณ๐—ฟ๐—ฒ๐—ฒ๐—ฑ๐—ผ๐—บ ๐˜๐—ผ ๐—ฑ๐—ผ ๐˜€๐—ฐ๐—ถ๐—ฒ๐—ป๐—ฐ๐—ฒ, and the people who make it possible. In 2023, we released a statement on the online targeting of researchers: https://lnkd.in/dbRrUDBu

Suomen Akatemia tuomitsee jyrkรคsti tutkijaan kohdistuvan hรคirinnรคn ja vihapuheen.

โ€In Finland, academic freedom is a core value. Researchers must be able to explore, question and share knowledge openly.โ€

โ€Letโ€™s protect the freedom to do science, and the people who make it possible.โ€

27.06.2025 20:07 โ€” ๐Ÿ‘ 304    ๐Ÿ” 66    ๐Ÿ’ฌ 4    ๐Ÿ“Œ 4
A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg  and Julie

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

๐Ÿšจ JOB ALERT ๐Ÿšจ
We're hiring a Research Assistant โ€“ no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired ๐Ÿงซ๐Ÿ”ฌ
Apply now ๐Ÿ‘‰ www.nature.com/naturecareer...

#STEMCareers #ResearchJobs

23.06.2025 13:00 โ€” ๐Ÿ‘ 49    ๐Ÿ” 32    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 5
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The EMBO workshop on ESCRT proteins is up and running at Caux Palace. The view from the hotel room to Lac Leman is rather amazing!

23.06.2025 16:49 โ€” ๐Ÿ‘ 9    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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RCF winter call results: funding decisions in biosciences, health and environmental research The Research Council of Finland’s Scientific Council for Biosciences, Health and the Environment has granted funding for 38 Academy Research Fellowships, 12 Clinical Researchers and 76 Academy P...

I'm grateful for the Research Council of Finland for granting me the Academy Research fellowship! After getting over the shock I will soon move back to Finland to start as a group leader at the Institute of Biotechnology @helsinki.fi. Looking for a PhD student soon! www.aka.fi/en/about-us/...

22.06.2025 09:18 โ€” ๐Ÿ‘ 40    ๐Ÿ” 9    ๐Ÿ’ฌ 9    ๐Ÿ“Œ 0
An illustration showing a set of lines of different colors labeled library of oligos and a broken circle labeled backbone. Then an arrow with a question mark and ligase polymerase and on the other side a sect of circles with the colored lines added into the gap labeled library of plasmids.

An illustration showing a set of lines of different colors labeled library of oligos and a broken circle labeled backbone. Then an arrow with a question mark and ligase polymerase and on the other side a sect of circles with the colored lines added into the gap labeled library of plasmids.

๐ŸงชHey Sciencers,

We're looking to make a library of 50-100 plasmids that differ in ~60bp stretch. The differences will be designed (not random). The library will then be screened for a phenotype.

What is the best way to do this?

Cost is an issue.

16.06.2025 19:39 โ€” ๐Ÿ‘ 2    ๐Ÿ” 5    ๐Ÿ’ฌ 7    ๐Ÿ“Œ 2

It's fellowship season in the EU. If you want to talk and join our group at the amazing MDC in Berlin on a fellowship, please write me an email.

We do cryo-EM/ET, membrane proteins, data science/AI, our work: scholar.google.com/citations?so...

Fellowships: Marie Curie, EMBO, HFSP, Humboldt...

19.05.2025 12:44 โ€” ๐Ÿ‘ 2    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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๐Ÿงต5 Top Free Alternatives to BioRender for Scientific Illustrations!

These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.

Save and share the post!

13.05.2025 19:55 โ€” ๐Ÿ‘ 677    ๐Ÿ” 349    ๐Ÿ’ฌ 32    ๐Ÿ“Œ 6
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Advancing Super-Resolution Microscopy: Recent Innovations in Commercial Instruments Abstract. Super-resolution microscopy techniques have accelerated scientific progress, enabling researchers to explore cellular structures and dynamics wit

We have a new review out! In this Microscopy & Microanalysis piece, Louisa Mezache and I survey some of the latest commercially available microscope technologies: Nikon NSPARC, Re-scan Gaia, CSR Biotech MI-SIM, refinements to STED, SMLM from Bruker and Abbelightโ€ฆ Check it out with free access:

09.04.2025 15:47 โ€” ๐Ÿ‘ 107    ๐Ÿ” 44    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 4