Burcu Darst

Validation and context-dependent effects of a prostate cancer polygenic risk score in the All of Us Research Program This investigation demonstrates the validity and high predictive ability of a prostate cancer polygenic risk score (PRS) across populations in the All of Us Research Program. It further demonstrates t...

🧬New from @burcudarst.bsky.social & co
📄Validation and context-dependent effects of a prostate cancer polygenic risk score in the #AllofUs Research Program

The Rory Gilmore Reading Challenge Over the course of seven seasons of Gilmore Girls, Rory Gilmore was seen reading 339 books on screen. How many have you read? From...

For #Readers: The Rory Gilmore Reading Challenge is pretty darn great. It has the 339 books (novels, nonfiction, plays, poetry) that Rory of the The Gilmore Girls* is shown reading. I'm only at 23% so I need to get to steppin'.

* I've haven't seen an episode...yet.

share.google/2IBopgRRRtpf...

8 high level positions at NIH posted including 6 institute director positions (NIMH, NIGMS, NICHD, NIDCR, NHGRI, NLM).

Only open for 2 weeks (applications due November 21).

Application materials include a) CV b) vision statement c) a photocopy of doctoral degree.

hr.nih.gov/careers/open...

uva rejects the compact

ASHG 2025 PRIMED Abstracts

Attending #ASHG25? Learn how @prsmethods.bsky.social investigators are improving polygenic risk prediction in diverse populations by visiting these talks and posters docs.google.com/spreadsheets...

Further, while PRS are highly predictive of T2D risk across populations, more work is needed to ensure equitable clinical utility.

HUGE thank you to the many collaborators across many cohorts and biobanks who made this work possible! (3/3)

Our findings suggest that across populations, PRS have the potential to inform early interventions for T2D and risks of T2D complications and comorbidities. However, it is important to consider contexts to interpret PRS, as T2D PRS performance varies based on demographic and lifestyle factors. (2/3)

Polygenic risk score for type 2 diabetes shows context-dependent effects across populations - Nature Communications Polygenic risk scores can help identify individuals at higher risk of type 2 diabetes. Here, the authors characterise a multi-ancestry score across nearly 900,000 people, showing that its predictive value depends on demographic and clinical context and extends to related traits and complications.

Excited to share our recent work characterizing a type 2 diabetes (T2D) polygenic risk score (PRS) in a collaboration that included 244,637 T2D cases and 637,891 controls, led by @boyaguo.bsky.social! (1/3)

www.nature.com/articles/s41...

Fred Hutch Girls Who Code Fall 2025 Application Please click the link to complete this form.

Fred Hutch Girls Who Code is rolling again with another session on computational biology! Please share the word with high school students and educators

📅 Tuesdays 4:30-6pm, Oct 14 - Dec 2
📍 Fred Hutch (in-person)
🎯 Small groups, comp bio & fun

Apply by Oct 10: form.jotform.com/fredhutch/fr...

Huntington's disease successfully treated for first time One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

New cures feel sudden, but the seeds were planted decades ago by basic scientists.

Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵

Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a critica...

PRS are well know to have variable performance across ancestries, frequently with a European bias. We looked closely at fairness of PRS for CVD risk prediction, both with PRS on it's own and in an integrated risk score...

Our results were surprising... 👉 www.medrxiv.org/content/10.1...

Best of both worlds: You can pass a Linux command to data.table
jozef.io/r917-fread-c...

This is now the third year that I'm reminded how greatful I am to @jkpritch.bsky.social when I'm preparing my human genetics lectures, for An Owner's Guide to the Human Genome (web.stanford.edu/group/pritch...). It really is the textbook we are all missing. Its crazy no real alternative exists.

I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.

This was neat work by @nmancuso.bsky.social et al developing and benchmarking a new multi-ancestry fine-mapping method (“SuShiE”). I learned something about the performance of pooled v stratified analyses but still have some Qs. 1/n

Our Department of Health issued a Standing Order for the COVID-19 vaccine today, as we work to ensure that all Washingtonians 6 months or older have access to these vaccines.

I will do everything in my power to protect our residents with policies still based in rigorous science.

UCSC Genome Browser User Satisfaction Survey | SurveyMars I have posted a survey titled 'UCSC Genome Browser User Satisfaction Survey' on SurveyMars. Please help me by filling it out. Thank you very much!

Please take a moment to tell us how you use the Genome Browser: surveymars.com/q/mnb...

Your feedback supports future improvements and our continued funding.

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...

I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)

Yesterday the president demanded that evidence about Covid vaccines be shown to the public. Today @apoorvanyt.bsky.social & I run through some of the studies made public over the past 4+ years that show that the vaccines work. Gift link: nyti.ms/46k17Tq

You're invited to the 3rd Annual BACPAC #ProstateCancer Community Research Symposium — a free event hosted by Fred Hutch Cancer Center and @uwmedicine.bsky.social, in collaboration with BACPAC and ZERO Prostate Cancer.

Register: https://bit.ly/4fSYyv5

An arrow with a LaTeX equation

Trigonometric functions and a unit circle

A bivariate change model with structured residuals

A hierarchical model of cognitive abilities

Now on CRAN, ggdiagram is a #ggplot2 extension that draws diagrams programmatically in #Rstats. Allows for precise control in how objects, labels, and equations are placed in relation to each other.
wjschne.github.io/ggdiagram/ar...

Rapid Response: Reinvesting in Racial and Indigenous Health Equity Research The purpose of this call for proposals is to meet the current moment by supporting timely, actionable health equity research that has been interrupted by shifts in federal funding.

ATTN: Robert Wood Johnson has money to support “canceled” research on racial-indigenous health equity

www.rwjf.org/en/grants/ac...

I'm looking to recruit a PhD student to study patterns of local adaptation and introgression across the spruce hybrid zone in the Rockies near Calgary. Projects can include field work, bioinformatics, pop gen theory, or comparison to plant/ conifer species
yeamanlab.weebly.com/uploads/5/7/...

An anole extends its dewlap, which says "call for scientists!"

Seeking scientist volunteers for this fall! Want to practice science communication and help author a 🌟comic🌟 about your research? I need collaborators for the next cohort of SciComm & Comics art and design students. All countries and scientific fields eligible.

We are hiring into 3 (THREE!) tenure track lines this year at Wake Forest — if you’re looking please reach out, I love chatting about our department! We are a vibrant group that love & embrace the teacher-scholar model 👩‍🏫

happy to say my new department is hiring an associate/full professor: academicjobsonline.org/ajo/jobs/30328

please apply!

Open Call for Expressions of Interest in Max Planck Directorships: Expressions of interest can be submitted until 31 October 2025.

Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.

ICYMI it's not a Max Planck directorship but still a great opportunity to join an exciting research environment down under 😁 bsky.app/profile/mike...

Are you an early-career biologist or ecologist who would benefit from an invited seminar? Would you like to come to UMaine next fall or spring to give a talk? Leave a brief comment with some info about what you do. I'm co-hosting our seminar series again, and am filling out our rosters.