Fleur Ferguson

‼️ Call for Nominations🏅Chi-Huey Wong Chemical Biology Award

1️⃣ Official Nomination Form

2️⃣ Nomination Letter (maximum 1,000 words)

🙅 Self-nominations will not be considered

📅 Nominate before October 31, 2025

👉 Ms. Marene Chan
📧 jccs@gate.sinica.edu.tw

🌐 chemistry.org.tw/award_chwong/

Pew Awards 22 Researchers Biomedical Science Grants

Incredibly honored to be named a 2025 Pew Scholar in the Biomedical Sciences! 🧬 Grateful to Pew Trusts for this recognition and support, and to my awesome lab team, mentors and colleagues at @ucsdhealthsci.bsky.social Excited for what's ahead!
www.pew.org/en/about/new...

ZBTB11 depletion targets metabolic vulnerabilities in KRAS inhibitor-resistant PDAC - Nature Chemical Biology Depletion of a transcriptional factor ZBTB11 using molecular glue degraders can overcome oxidative-phosphorylation-mediated KRAS inhibitor resistance in pancreatic ductal adenocarcinoma with low acute...

Excited to share our latest work developing molecular glue degraders of ZBTB11, now out in @natchembio.nature.com
www.nature.com/articles/s41...

Rewiring DNA repair with PARP-based chemical inducers of proximity Chemical inducers of proximity (CIPs) can elicit durable, and often neomorphic, biological effects through the formation of a ternary complex, even at low equilibrium occupancy of their targets. This ...

New work out today introducing PCIPs, heterobifunctional chemical inducers of proximity that inhibit DNA repair by recruiting BET proteins to PARP2. Great work uncovering a new form of event-driven pharmacology by Bryce/Eric/Erin and the rest of the team. (1/3)

www.biorxiv.org/content/10.1...

📣 Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org
#ubiquitin

Faculty/Health Educator Job: Assistant/Associate Professor, Chemical Biology at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA Assistant/Associate Professor, Chemical Biology job

We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...

Development of PROTACs for targeted degradation of oncogenic TRK fusions Chromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRK) with diverse partner proteins have been identified as oncogenic drivers in many adult and pediatric cancers. Whil...

🚨 New preprint!

Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson‬ lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...

Download and distribute our (massive) database of funding opportunities and fellowships for POSTDOCs

Cuts across all fields of research. 293 fellowships with info about deadline, amount, field, eligibility, etc.

Good luck!

Download this database freely here: research.jhu.edu/rdt/funding-...

Registration for the 2025 San Diego MedChem Symposium is now open! Come join us for a free event on UCSDs campus.

A big congratulations to the newly minted Dr. Forrest @inesforrest.bsky.social. Super proud! A big thanks to her committee members @michael-erb.bsky.social @wisemanlab.bsky.social @fleurmferguson.bsky.social @shenvi.bsky.social

So much fun sharing MrTAC with Keystone and seeing old friends and making new ones @fleurmferguson.bsky.social @stevenbanik.bsky.social @dannomura.bsky.social @danetteldaniels.bsky.social #lysosome #tpd

Really enjoyed this proximity-based therapeutics keystone conference! Appreciate the organizers Fleur @fleurmferguson.bsky.social and Phil for the opportunity and for putting together this wonderful event!

Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!

Big thanks to @womenintpd.bsky.social for this amazing initiative and support in empowering women in the field! Grateful and excited to attend @keystonesymposia.bsky.social soon and make the most of this incredible experience! ✨️

Congratulations to both of you! @WomeninTPD first official scholarship award winners ☺️

Chemical Biology Postdoc in the Ferguson Lab at UCSD Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

Chemical Biology Postdoc in the Ferguson Lab at UCSD #ScienceJobs #AcademicSky jobrxiv.org/job/univ...

Thoughts for the future Nature Chemical Biology - As Nature Chemical Biology approaches its third decade we asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most...

We asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?”

You can read that they said in our Feature “Thoughts for the future” – Free to read in January. rdcu.be/d5Ksw

Please share widely - we are hiring, come join our team!

January 2025 cover

Our January issue is live and it’s our 20th Anniversary Issue!

www.nature.com/nchembio/vol...

It includes a collection of Retrospective News & Views on historical developments in the field, a Feature “Thoughts for the future” from chemical biologists on the next challenges, and more.

Chemical Biology Postdoc in the Ferguson Lab at UCSD Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

We are hiring! Apply to join our dynamic team as a #chemicalbiology postdoc or research scientist below.
Chemical biology: jobrxiv.org/job/universi...
Mass spectrometry: jobrxiv.org/job/universi...

Here is the link for the Keystone Conference:
www.keystonesymposia.org/conferences/...
Thank you to the organizers @fleurmferguson.bsky.social and Phil Chamberlain for helping us coordinate and setup this opportunity.

Join us for the final TPD webinar of 2024 on 12/19.

@fleurmferguson.bsky.social & Eric Wang - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC"

Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"

Awesome collaboration with the Fischer and Sellers labs at HMS, and with Charu Chaudhry at J&J!

A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharm....

Excited to share our work investigating how ligand residence time influences targeted protein degradation outcomes at scale, and how we can combine kinetic scout degrader approaches with mathematical modeling to accelerate hit finding and optimization!
onlinelibrary.wiley.com/doi/abs/10.1...

Covalent targeting of splicing in T cells Despite significant interest in therapeutic targeting of splicing, few chemical probes are available for the proteins involved in splicing. Here, we s…

New paper out of Katya Vinogradova’s lab! www.sciencedirect.com/science/arti...