Carlos Rodrรญguez's Avatar

Carlos Rodrรญguez

@carloslab.bsky.social

#newPI studying plant chemical diversity through Mass Spectrometry, and Natural Products biosynthesis whenever I can. Opinions are my own. ๐Ÿ‡ฒ๐Ÿ‡ฝ

522 Followers  |  1,362 Following  |  20 Posts  |  Joined: 14.12.2023  |  1.6423

Latest posts by carloslab.bsky.social on Bluesky

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Call for Ambizione

Ambizione grants are aimed at early-career researchers who wish to conduct and lead a project of their own. Interested in learning more about this call? Take part in our online info event on 14 August 2025.

Submission deadline: 4 November 2025

โžก๏ธ buff.ly/dDQl9QA

05.08.2025 08:50 โ€” ๐Ÿ‘ 17    ๐Ÿ” 12    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Iโ€™ve been mystified for years why my line of research (which includes genetic engineering of plants) makes (German) people so much more upset than the AI work of my campus neighbors.

And why does eco-anxiety have a @wikipedia.org page, but not AI-anxiety?

30.07.2025 06:39 โ€” ๐Ÿ‘ 17    ๐Ÿ” 5    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Also, I can tell you exactly all the components on your sample with a single test, including concentrations and place of origin! That's why my screen has all these spinning structures.

27.07.2025 20:43 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Hello, I am a scientist in a film. All my liquids are brightly coloured. The time it takes to perform tests and experiments is dependent on plot requirements, not biology or chemistry. Also, my safety glasses are extremely stylish.

27.07.2025 13:29 โ€” ๐Ÿ‘ 1056    ๐Ÿ” 99    ๐Ÿ’ฌ 24    ๐Ÿ“Œ 51

Fiiiine, apparently half my readers enjoy an info dump, so here we go!

Grasslands Sequester Carbon Too or โ€œWhy trees are not the be-all and end-all.โ€

Ahem. *takes a sip of water*

25.07.2025 23:50 โ€” ๐Ÿ‘ 2190    ๐Ÿ” 586    ๐Ÿ’ฌ 68    ๐Ÿ“Œ 113

We owe this confidence to generations of scientists who pushed the boundaries of knowledge, not knowing if their efforts would make a difference. Oliver and Schafer didnโ€™t put calf adrenal extracts into dogs to save my son but because they thought the world should know what adrenal glands do. 20/n

05.05.2025 07:11 โ€” ๐Ÿ‘ 383    ๐Ÿ” 41    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 4
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Expansion of the Stereochemical Space of Triterpenes by Mining Noncanonical Oxidosqualene Cyclases Across the Diversity of Green Plants Triterpenoids and steroids are structurally complex polycyclic natural products with potent biological functions, for example, as hormones. In all eukaryotes, the carbon skeletons of these compounds a...

Started as a very successful master thesis, now published in JACS. Screening sequence similarity networks turned out to be a great way to discover oxidosqualene cyclases with unusual activity from more than thousand plant transcriptome sequence datasets.

pubs.acs.org/doi/10.1021/...

18.03.2025 10:15 โ€” ๐Ÿ‘ 14    ๐Ÿ” 9    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Authoritarians love "Gen AI" because it
- Sounds confident even when factually wrong
- Broadly conforms to & reproduces their biases, off the shelf
- Lets them create bespoke realities (text, audio, moving & still image) which agree w/ their biases
- Degrades trust in knowledge/evidence/expertiseโ€ฆ

24.04.2025 14:05 โ€” ๐Ÿ‘ 2638    ๐Ÿ” 999    ๐Ÿ’ฌ 39    ๐Ÿ“Œ 56
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Three-step biosynthesis of salicylic acid from benzoyl-CoA in plants - Nature The salicylic acid (SA) biosynthesis pathwayโ€”involving ligation of benzoyl coenzyme A and benzyl alcohol to give benzyl benzoate; hydroxylation of benzyl benzoate to give benzyl salicylate; and cleava...

Three back-to-back Salicylic Acid biosynthesis papers 1/3 www.nature.com/articles/s41...

23.07.2025 15:50 โ€” ๐Ÿ‘ 37    ๐Ÿ” 18    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 1

The 64th Annual Meeting of the Phytochemical Society of North America (#PSNA2025) starts today at York University, Toronto. We welcome all attendees to dive into groundbreaking phytochemical research, vibrant networking, and fun experiences! #PlantScience #Phytochemisty
Download detailed programme

24.06.2025 17:50 โ€” ๐Ÿ‘ 2    ๐Ÿ” 3    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Rachel Thomas, PhD - Deep learning gets the glory, deep fact checking gets ignored an AI researcher going back to school for immunology

"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...

04.06.2025 15:53 โ€” ๐Ÿ‘ 93    ๐Ÿ” 47    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 5

Highly recommended read on the discovery of a very, very elusive enzyme!

20.06.2025 01:04 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

Today in Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III & deBz-deoxy-Taxol #SingleCell #secmet ๐Ÿงฌ๐Ÿงช๐ŸŒพ

11.06.2025 19:49 โ€” ๐Ÿ‘ 113    ๐Ÿ” 43    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 6
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Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

Fantastic work by the Sattely group on taxol biosynthesis, featuring a highly innovative application of single nuclei sequencing to find elusive biosynthetic genes ๐Ÿ‘
www.nature.com/articles/s41...

11.06.2025 19:48 โ€” ๐Ÿ‘ 20    ๐Ÿ” 11    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
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Hi everyone! Iโ€™m new to Bluesky. At the beginning of the year, I moved to Zurich @UZH_en to start a postdoc with #CyrilZipfel and @pedrobeltrao.bsky.social, investigating protein phosphorylation in plants ๐ŸŒฑ

If youโ€™re nearby or working on something similar, letโ€™s connect ๐Ÿ˜€

01.06.2025 21:24 โ€” ๐Ÿ‘ 117    ๐Ÿ” 26    ๐Ÿ’ฌ 6    ๐Ÿ“Œ 0

New preprint out from the @oconnorlab.bsky.social department led by Moonyoung Kang, Anh Vu and Lorenzo Caputi.
Metabolomics and RNA-seq on the same single cell!

Or as we call it here in the lab: "the split-cell method"

23.05.2025 15:44 โ€” ๐Ÿ‘ 5    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1

I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.

Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design

Please repost for reach ๐Ÿ’š

02.05.2025 14:39 โ€” ๐Ÿ‘ 161    ๐Ÿ” 283    ๐Ÿ’ฌ 7    ๐Ÿ“Œ 4
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Laboratory Technician, Department of Plant and Environmental Sciences

We're hiring!
๐Ÿฅผ 2-year lab technician at UCPH from 01 Aug
๐ŸŒฟ Support our research in plant natural products with relevance in agriculture, nutrition, and medicine.
๐Ÿงฌ Your skills: plant molecular biology and/or tissue culture & transformation
๐Ÿ“… Deadline 18 May 2025
jobportal.ku.dk/administrati...

16.04.2025 13:27 โ€” ๐Ÿ‘ 4    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Hello Bluesky! ๐ŸŽ‰ The Photochemical Society of North Americaโ˜˜๏ธ is here! We'll be sharing all the latest updates on PSNA2025. Don't miss out on early bird registration โ€“ it's still available! Join us! #PSNA2025 #Photochemistry
#Science
www.psna2025.com/register

11.03.2025 12:14 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

It's working now! It was temporary

29.03.2025 01:36 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Thanks! I think lately I just panic whenever a database is down :(

27.03.2025 22:29 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Is anyone else having problems with MASSive? Anyone know if the repository is going to remain active? #MassSpec

27.03.2025 18:25 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Sarah O'Connor is a new member of the Leopoldina Sarah O'Connor has been elected as a new member of the Leopoldina's Section for Organismic and Evolutionary Biology. Election to the oldest scientific society in the German-speaking world is one of th...

Our director Sarah O'Connor, head of the Department of Natural Product Biosynthesis @oconnorlab.bsky.social, has has been elected a member of the German National Academy of Sciences, the #Leopoldina! Congratulations! ๐Ÿ‘
www.ice.mpg.de/492460/sarah...

27.03.2025 15:42 โ€” ๐Ÿ‘ 28    ๐Ÿ” 6    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Anyone knows of an alternative to GenBank for depositing sequences? An EBI mirror like the ENA is to the SRA?

19.03.2025 23:28 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Radicalize your loved ones before they get radicalized.

09.03.2025 00:33 โ€” ๐Ÿ‘ 29    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Opening at UdeM Biochemistry department for a professor position in bioinfomatics!

www.umontreal.ca/public/www/d...

03.03.2025 15:15 โ€” ๐Ÿ‘ 4    ๐Ÿ” 7    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Pictures of Lise Meitner Group leaders: Sofie Valk, Flore Kunst, Anna-Maria Meister, Maria Sokolova, Heidi Colleran, Nathalie Feiner und Ulrike Kraft.

Pictures of Lise Meitner Group leaders: Sofie Valk, Flore Kunst, Anna-Maria Meister, Maria Sokolova, Heidi Colleran, Nathalie Feiner und Ulrike Kraft.

A new round of the Lise Meitner Excellence Program for #tenuretrack group leaders opened today - please consider applying! The program aims to recruit and promote exceptionally qualified female scientists. www.mpg.de/lise-meitner... #LiseMeitnerGroups #WomeninScience #ScienceCareer

12.02.2025 14:46 โ€” ๐Ÿ‘ 72    ๐Ÿ” 53    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 6

This preprint makes a point that is valid for a lot of machine learning approaches. Organisms or genes are linked by evolutionary history; they are not independent. This results in correlation between learning and test sets, and often in over-optimistic evaluations of the methods' outcome.

18.01.2025 18:25 โ€” ๐Ÿ‘ 59    ๐Ÿ” 27    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 0

The latest one on the withanolide clusters. I believe this is number 3 within three months?! Contains previously not yet elucidated part of the pathway from what I can see after a brief look.
#PlantScience
#NatProd

29.12.2024 13:39 โ€” ๐Ÿ‘ 8    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

A new paper out from our @oconnorlab.bsky.social department led by @angelicagg.bsky.social and Tobias Kรถllner. They optimised expression of an insect pathway in Benthy. Expressing insect proteins in plants is often not as easy as it sounds so this is a nice story! Congratulations!
#PlantScience

28.12.2024 07:44 โ€” ๐Ÿ‘ 16    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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