Phil Biggin

Home Office advisers launch review of UK visas to attract top talent Study by independent committee announced as concerns grow that immigration crackdown will hit fiscal plans

This sounds like a step in the right direction.

www.ft.com/content/89ba...

In-person training. 7th UK Workshop on Membrane Proteins. Birmingham, UK. 15-17 April 2026. Includes Biochemical Society logo, image of scientists in lab coats, in a lab, and event logo.

There are still a few places left for the 7th UK Workshop on Membrane #Proteins! Join us from 15-17 April at Aston University to understand the basics of membrane protein purification using cutting edge methods 🧪 ow.ly/rx0B50YbAUt

If you are a #GROMACS user and/or interested in #moleculardynamics simulations join us next week for our "What's new in GROMACS 2026.0" #webinar

🗓️ 3 March 2026, 15:00 CET
✍️ bioexcel.eu/cpok

@gromacs.bsky.social

Cool opportunity here!

Structural determinants for GPCR-mediated inhibition of TASK K2P channels by diacylglycerol and its dysfunction in disease - The EMBO Journal Two-Pore Domain K+ (K2P) channels are crucial determinants of the resting membrane potential and of cellular electrical excitability in many different cell types. TASK-1 and TASK-3 K2P channel activit...

Great to see this paper out with @profkalium.bsky.social - with MD from David Seiferth.

GqPCR inhibition inversely correlates with channel open probability, and results from a state-dependent destabilisation of the open state by DAG promoting channel closure.

link.springer.com/article/10.1...

Absolutely brilliant!

Come work with Ben Berks FRS in Oxford
2 x PDRA posts: Molecular Analysis of Bacterial Outer Membrane Protein Biogenesis

2 complementary projects investigating bacterial outer membrane protein biogenesis. Building on our recent work (Nature (2015) 647: 479-487)

my.corehr.com/pls/uoxrecru...

UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6 Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...

Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR

The Lipid Interactome: an interactive and open access platform for exploring cellular lipid–protein interactions AbstractSummary. Lipid–protein interactions play essential roles in cellular signaling and membrane dynamics, yet their systematic characterization has lon

This is SO COOL!!!

academic.oup.com/bioinformati...

MDAnalysis is participating in #GSoC 2026!

👉 Read our blog post for details on how you can apply to work with MDAnalysis through GSoC: www.mdanalysis.org/2026/02/19/g...

🗓️ Pre-proposals must be submitted by March 9.

❗For transparency and fairness, use public forums for all #GSoC communications.

Congratulations!

Learning the committor without collective variables - Nature Computational Science By learning directly from atomic motion, without the need for handcrafted descriptors, a graph neural network reveals how molecular systems change state, delivering accurate kinetics and atom-level in...

📢Out now! Work from @chipotlab.bsky.social and colleagues presents a method that learns from atomic motion without the need for handcrafted descriptors, allowing for accurate kinetics and atom-level insights. www.nature.com/articles/s43...

🔓 rdcu.be/e4p3B

🧐 Who will be presenting their #research projects during the upcoming #Theory #workshop in #Hünfeld? ⏩ Take a look at the program and list of #speakers. www.mpinat.mpg.de/workshop/hue... #Registration for 🖥️ online only participation is still open...

Ever get tired of tiny timesteps bottlenecking your MD simulations?

We show how to train a model for large-timestep Hamiltonian dynamics directly on standard MLFF datasets. 𝗡𝗼 𝗿𝗲𝗳𝗲𝗿𝗲𝗻𝗰𝗲 𝘁𝗿𝗮𝗷𝗲𝗰𝘁𝗼𝗿𝗶𝗲𝘀, 𝗻𝗼 𝘂𝗻𝗿𝗼𝗹𝗹𝗶𝗻𝗴, 𝗻𝗼 𝘁𝗲𝗮𝗰𝗵𝗲𝗿 needed!

🧵👇

Insights from aquaporin structures into drug-resistant sleeping sickness.

🔗 buff.ly/Y0A47zR

Webinar: From Quick Script to Reproducible Workflow: Small Research Software Engineering Habits, Big Impact (2026-02-17) Date: 17 February 2026 Time: 15:00 CET Registration Abstract Reproducible analysis pipelines sound great in theory, but what does that look like in the life of a busy researcher doing biomolecular sy...

⏰ Don't forget to register for our #webinar tomorrow, 17 February 2026, 15:00 CET
✍️ bioexcel.eu/7c2s

"From quick script to reproducible workflow"

#molecularsimulations #workflows #FAIR #SoftwareEngineering

@coderefinery.org

Molecular dynamics simulations reveal DNA gate opening mechanisms for M. smegmatis topoisomerase 1A Type 1A topoisomerases relax torsional strain in DNA via a strand passage mechanism in which a protein-mediated DNA gate must open during the enzyme’s catalytic cycle. This gate-open conformational…

#OPENACCESS: Molecular dynamics simulations reveal DNA gate opening mechanisms for M. smegmatis topoisomerase 1A. Deepesh Sigdel and Maria Mills. buff.ly/GZXDTzi

Research Associate on genAI applied to drug discovery (ref. PD/25/23) - IRB Barcelona IRB Barcelona is seeking a talented and highly motivated Research Associate to join the Structural Bioinformatics and Network Biology group (https://sbnb.irbbarcelona.org), led by Dr. Patrick Aloy,...

🚀 JOB OPPORTUNITY: Research Associate in GenAI applied to Drug Discovery! 🧬

Full details: recruitment.irbbarcelona.org/jobs/6928145...

There's still time to make a 16 February poster abstract deadline for the Molecular and ion flows #FaradayDiscussion, Manchester, 13-15 April 2026. Poster presenters can expect lively discussions, networking, and a collaborative atmosphere where every delegate can contribute. #ChemSky #Nanofluidics

Our new preprint. First prospective use of a transformer model for drug repurposing against Streptococcus pneumoniae, a major AMR threat. Great collaboration with Nick Croucher’s lab. Of 11 tested, 9 showed strong activity, some against multidrug‑resistant strains.
#AI #AMR

Second time this month I've encountered a paper on MD simulations of protein kinases with no coordinates from the trajectory provided. I'd like a few snapshots or cluster centroids. Something.

Makes these papers essentially useless.

Structural basis for domain coupling in heteromeric glycine receptors revealed by an atypical allosteric agonist Counteracting ligands stabilize glycine receptor states revealing mechanisms of pentameric ligand-gated channel allostery.

Check out our latest paper on the glycine receptor with
@chakrapanilab.bsky.social

where we show the interplay between the orthosteric and allosteric binding sites.

www.science.org/doi/10.1126/...

Associate Director, Computational Chemistry at Takeda Pharmaceutical Learn more about applying for Associate Director, Computational Chemistry at Takeda Pharmaceutical

Takeda (Boston, MA) looking for Associate Director, Computational Chemistry, (PhD, 7+ yrs exp): jobs.takeda.com/job/boston/a... #chemjobs #compchem

(position pretty old, Nov 2025 posting)

Happy that simulations, performed by Gabriel Diaz, stellar master student in the team, helped to decipher how PIP2 lipids help recruiting Munc13 protein to prime synaptic vesicle Collaborative work led by F. Pincet @normalesup.bsky.social

full story at @pnas.org : www.pnas.org/doi/10.1073/...

In-person training. 7th UK Workshop on Membrane Proteins. Birmingham, UK. 15-17 April 2026. Includes Biochemical Society logo, image of scientists in lab coats, in a lab, and event logo.

Registration is open for the 7th UK Workshop on Membrane #Proteins! Join us from 15-17 April to understand the basics of membrane protein purification using cutting edge methods. Places are limited, save £50 with our earlybird discount if you register before 15 February: ow.ly/rx0B50YbAUt

Photo of panel discussion from our careers event, with Lizzie Coker (AZ), Marta Polak (J&J), and Ben Hall (UCL)

Inspiring computational #cancer careers session yesterday with speakers from J&J and AZ!

Interested in the field? On Friday I’m giving a lecture to introduce our new MSc Computational Cancer. Register below:

www.ucl.ac.uk/engineering/...

Congratulations Beatrix!

Indeed :-(

something to digest... ;-)

📩 Join our interdisciplinary team as #PhD student or #postdoc and contribute to the project "Theory and #Algorithms for Structure Determination from Single Molecule X-Ray Scattering Images", a new route to the structure determination of biomolecules. #job #XFEL in #Göttingen 🇩🇪
@mpi-nat.bsky.social