Gabriel Victora

Spoiler alert: you have to treat the organism.
& people who think in silico approaches are ready to replace animal models should not be included in adult conversations (ppl who want to develop them, very welcome, it's those who think they are ready for prime time that need to fuck all the way off)

In my simple brain, it's exciting but you need to understand the limitations: cell free systems allow you to ask q's about molecules; in vitro systems allow you to ask q's about molecules & cells; organoids may one day allow you to ask q's about mols, cells, and tissues/organs - but never organisms

Or have a listen to my convo with Tasuku Honjo & Pierre Golstein, whose labs discovered PD1 and CTLA4 respectively, and imagine a scenario where this is worked out with the current non-animal methods

www.embo.org/podcasts/fro...

We are not really there yet, not even close. The most valuable (in market terms) drugs out there today come fm understanding the incretin effect, the unexpected finding that oral & iv glucose provoke different insulin response. Can you see a road to that from any of the current animal alternatives?

Could go both ways. Feedback helps favor non-dominant clones like bnAb precursors, but it might make it harder for these clones to mature for long enough if at some point they do become dominant

Congrats @janabilanovic.bsky.social, Alex Barbulescu, and all other authors!

Antibody-mediated feedback modulates interclonal competition in the germinal center Antibodies generated by prior immune responses regulate B cell responses upon recall immunization. Barbulescu et al. examine whether antibodies produced by an ongoing immune response influence the out...

One more trick pulled off by antibody-mediated feedback

www.cell.com/immunity/ful...

Happy to present Gloss, our new computational method for the analysis of multi-modal LIPSTIC + scRNA-seq data coupling cell-cell interaction measurements with intracellular transcriptomes.

Paper: doi.org/10.1016/j.cr...

Led by an amazing PhD student Tamjeed Azad, with @victora.bsky.social

B Cell and Antibody Responses | Keystone Symposia Join us at the Keystone Symposia on B Cell and Antibody Responses, February 2027, in London, with field leaders!

Save the date!

www.keystonesymposia.org/conferences/...

'Here, we discover functional adaptation of resident lymphocytes within two distinct skin stem cell niches and show that through this communication, each niche adjusts to meet diverse tissue demands.'
#Preprint #Immunology
www.biorxiv.org/content/10.6...

A study from @danmucida.bsky.social and @victora.bsky.social showed how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of #foodallergies. #RockefellerScience #YearInReview

🔗: https://bit.ly/4hyS18b

Zincfinger

Immunological sin: how a person's earliest flu infections dictate life-long immunity Researchers are striving to understand the impact a phenomenon known as original antigenic sin has on immunity to the virus.

In @natureportfolio.nature.com: Researchers, including Rockefeller's own Gabriel Victora (@victora.bsky.social), are striving to understand the impact a phenomenon known as original antigenic sin has on immunity to the virus that causes the flu.

Congrats on a very important paper!

Secret to great science: find the absolute best collaborators 👇👇

Summer Undergraduate Research Experience | HHMI The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.

Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows

One more piece for the very interesting puzzle of how antibodies feed back onto B cell responses in an epitope-specific manner. Lots more still to learn!

Long story short, antibodies can modulate the balance between B cells of different epitope specificities, countering excessive expansion of dominant clones

Antibody-mediated feedback modulates interclonal competition in the germinal center Serum antibodies from prior immune responses regulate B cell activation and germinal center (GC) access upon recall immunization. However, how antibodies produced by an ongoing immune response influen...

Check out our latest preprint on the effects of antibody-mediated feedback on ongoing germinal center reactions, led by Alex Barbulescu and @janabilanovic.bsky.social

www.biorxiv.org/content/10.1...

@biorxiv-immuno.bsky.social Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation
www.biorxiv.org/content/10.1...
@ucberkeleyofficial.bsky.social

@biorxivpreprint.bsky.social Lymphatic constraint of germinal centers optimizes protective antibody responses
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social

Our B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...

AI-generated poster for a horror movie called "The Study Section" showing zombies reviewing NIH grants

I’ll take it. But I’ll be renewing my bet again next year

Very

I would be happy to be wrong in that case!

B and T cells—the organizing principle of the adaptive immune system - Lasker Foundation For their discovery of the two distinct classes of lymphocytes, B and T cells – a monumental achievement that provided the organizing principle of the adaptive immune system and launched the course of...

Renewing my yearly bet on Cooper/Miller for the Nobels.

One might think that I would learn after being wrong so many times, but one would be mistaken.

laskerfoundation.org/winners/b-an...

@cyrilpedia.bsky.social is biased, I’ve grilled him too many steaks

Congratulations to all, especially Rockefeller's @veenapadmanaban.bsky.social, a research associate in
@sohailtavazoie.bsky.social's lab, and Maria Cecilia Campos Canesso, formerly a postdoc in @danmucida.bsky.social and @victora.bsky.social’s labs. A very well-deserved recognition!

Congrats!! Increadibly well deserved, at the risk of stating the obvious!