Gabriel Victora

In the minority here, but I think it would be refreshing and I'd appreciate reading a piece like "On the value of reductionist science".

While *incredibly* valuable, not everything *needs* -omics and the like, let alone when only done because it _can_ be done, with an illusion of mechanism.

Oslo University's Johanne Tracey Jacobsen visited CCII this week & shared exciting progress in the application of cutting edge imaging techniques to decode dynamic T-B interactions in the Germinal Center.
#Immunology #GerminalCenter
www.jjacobsenlab.com

Open Positions｜Careers｜Center for Cancer Immunotherapy and Immunobiology Open Positions

Check it out, a great opportunity for people looking to start their own lab in Japan 👇
www.ccii.med.kyoto-u.ac.jp/en/careers-e...

a classic!

Germinal center clonal diversity trees as a musical score, a great image to start @victora.bsky.social's CCII seminar, "Replaying germinal center evolution on a quantified affinity landscape"
#GerminalCenter #Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/the...

Following Daniel @danmucida.bsky.social's session, Angelina Bilate @rockefelleruniv.bsky.social discussed strategies to identify antigen specific T cells.

www.science.org/doi/10.1126/...

@cyrilpedia.bsky.social

With a little help from my friend

A great start to a 3-day workshop: Daniel & Angelina Bilate discussing with students & postdocs at @ccii-kyoto.bsky.social all the obstacles faced & strategies to overcome them (or, more drastically, the thorny topic of when to pull the plug on a project).
www.ccii.med.kyoto-u.ac.jp/en/event/wor...

Our streamlined Junior PI application process asks you to submit:
a cover letter;
a research plan;
a current curriculum vitae;
brief narrative summary of your main research achievements;
Contact information for three references
#Immunology #Immunotherapy

www.ccii.med.kyoto-u.ac.jp/en/careers-e...

Great to be back for the last iteration of this great symposium. It will be missed!

Nice, thank you. Maybe some of these features will turn out to be broadly true whenever there is clonal expansion in adaptive immune systems

I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.

Thanks for the kind words. I’m curious, what parallels do you mean?

Another tour de force by the Victora lab. A must read for germinal center aficionados. There goes the weekend!

Additional credit to multiple members of the Matsen, Victora, and other labs, especially Jared Galloway for coding; @tylernstarr.bsky.social and @jbloomlab.bsky.social for deep mutational scanning; Ward lab for cryo-EM; and @thearmita.bsky.social and @yun-s-song.bsky.social for help with modeling

We took this idea seriously and applied it to germinal centers, evolving the same reaction over 100 times. No spoilers here, though I can tell you that the amount of data is huge, and some of the findings were pretty surprising. Please check out the preprint!

In his book Wonderful Life, Stephen Jay Gould proposes a thought experiment where one would replay evolution on Earth many times from the beginning, so as to find out what features would emerge reproducibly and which ones were contingent on historical accidents

Replaying germinal center evolution on a quantified affinity landscape Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...

Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch

www.biorxiv.org/content/10.1...

”replication crisis” has always been hyperbole. Scientists ALWAYS argued, called each other frauds, and eventually land on consensus. A lot of what van Leeuwenhoek observed in the late 1600s was NOT REPRODUCIBLE because nobody could make lenses like him. But he was right, about cells, and bacteria.

thanks to @danmucida.bsky.social, @kamphorstlab.bsky.social and Joel Ernst (UCSF) for reporting these problems and coming up with the solution!

In any case, an emerging solution seems to be to cross the host uLIPSTIC mouse to a cre line that is expressed in the thymus, such as Pou2F3-cre or Foxn1-cre, to enforce tolerance.

(though beware that such cre lines may also recombine in other tissues, eg tuft cells and lung epithelium).

This doesn't seem to be a problem for studying physiological settings or in short-term infection experiments (we never saw it ourselves in any of our own studies).

Dear uLIPSTIC users,

We have been getting reports that, under some more inflammatory settings like TB or chronic LCMV infection, uLIPSTIC-expressing lymphocytes adoptively transferred into cre-negative uLIPSTIC hosts may be rejected at later timepoints (>1 wk).

A collaborative study between the labs of @danmucida.bsky.social and @victora.bsky.social earlier this year showed how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of food allergies: bit.ly/4hyS18b

#FoodAllergyAwarenessWeek

Someone should try this for treating cancer (IYKYK)

myspace?

Congrats John!

New mechanism behind adaptive immunity revealed. It could impact how we design vaccines. - News Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted...

New imaging from @victora.bsky.social's lab reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. #RockefellerScience

Cool germinal center acrobatics from Juhee Pae et al, check it out!

www.nature.com/articles/s41...