Analysing pancreatic cancer researchers establish a neuron–cancer–microenvironment interactome & propose denervating tumours as a new therapeutic pathway

📹 @verat-h.bsky.social, @simon-renders-md.bsky.social
& Jasper Panten et al HI STEM Heidelberg in @nature.com

➡️ bpod.org.uk/archive/2025...

Pancreatic cancer is evasive. Is the nervous system the reason why? A growing body of research suggests tumours rely on proteins and genes that are unique to the nervous system to persist in the body.

Check out the outlook article in Nature Magazin with a focus on the role of neural innervation in pancreatic cancer featuring our Nature publication

www.nature.com/articles/d41...

*81. Heidelberg Grand Round*
zu den neuesten Erkenntnissen und Fortschritten in der Pankreaskarzinomforschung
Vorsitz: Andreas Trumpp (DKFZ/HI-STEM/NCT Heidelberg) & Christoph Michalski (UKHD/NCT Heidelberg)
📅 11. 11.25, 16 - 19 Uhr
📍 Kommunikationszentrum DKFZ
💻 Anmeldung: indico.dkfz.de/e/81hgr

New podcast episode 🚨 we hear from Andreas Trumpp & Vera Thiel about trace-n-Seq, a new technology that enables the molecular characterisation at single cell resolution of neurons, innervating any organ or tumour in preclinical models.

Listen or read: magazine.eacr.org/unlocking-ca...

Next-gen tools in cancer neuroscience The emerging field of cancer neuroscience is rapidly evolving, driven by novel technologies and tools. These include advances in single-cell and spati…

Happy to share the review out in @cp-cellreports.bsky.social
Thanks to amazing Sebastien Talbot and Alexander Birbrair

www.sciencedirect.com/science/arti...

Characterization of single neurons reprogrammed by #PancreaticCancer 🧪 www.nature.com/articles/s41...

There have been so many topics discussed on TWHAB that were initially put on our radar by Dr Topol, we should credit him as a co-host!

Characterization of single neurons reprogrammed by pancreatic cancer

www.nature.com/articles/s41...

Chasing Ghosts – The Quest to Capture Neurons in Pancreatic Cancer Neurons infiltrate pancreatic tumors, yet their molecular identity has remained elusive . How do these nerves shape the tumor microenvironment and influence cancer progression? Using Trace-n-Seq, we m...

A bit of the backstory to our recent Nature paper. Find out more in the „behind the paper“ with @hi_stem_lab @dkfz.bsky.social
Thanks again to all the co-authors specifically @simon-renders-md.bsky.social and Jasper Panten

communities.springernature.com/posts/chasin...

Pinpointing neurons that hinder cancer treatment Method to identify neurons associated with pancreatic cancer.

A technology to identify and profile mouse neurons that connect the spinal cord to pancreatic cancer might improve treatment of this disease

https://go.nature.com/40ZoYUK

oops, actually three cancer neuroscience papers, number three, very cool combination of retrograde tracing and single cell analyses: www.nature.com/articles/s41...

Pinpointing neurons that hinder cancer treatment Method to identify neurons associated with pancreatic cancer.

and the News & Views: www.nature.com/articles/d41...

Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature.
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...

Today @nature.com on how pancreatic cancer can hijack our nervous system and how denervation may be therapeutic
www.nature.com/articles/s41...