Dr Vipin M Vashishtha

A review of some 3,000 studies implicates microplastics in a variety of serious health problems. These include male & female infertility, colon cancer and poor lung function. The particles also may contribute to chronic pulmonary inflammation, which can increase the risk of lung cancer. 1/

A NEW study has found that higher scores on the Dietary Inflammatory Index (DII) are associated w/ an increased incidence of all-cause dementia & Alzheimer's disease dementia. Diets that correlate w/ low DII scores may prevent late-life dementia

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Bad news for RSV vaccine development for infants!

The FDA halted enrollment of young children in RSV vaccine trials after 5 infants developed severe RSV infections who received one of Moderna’s mRNA vaccines for RSV during a phase 1 trial.

www.healio.com/news/pediatr...

A 24-month National Cohort Study examining long-term effects of COVID-19 in children and young people - Communications Medicine Stephenson, Pinto Pereira et al. investigate the proportion of children and young people with Post Covid-19 condition 24-months post-infection. Only 7.2% meet the definition consistently at 3-, 6-, 12...

When researching LongCOVID, we need to consider clinical impairment and the range of symptoms reported. 5/5

www.nature.com/articles/s43...

Reinfected children and young people had more symptoms than children and young people who report one infection; those who report no infection had the lowest symptom burden. 4/

They found that 7.2% of children and young people consistently meet the ‘Long COVID’ research definition at 3-, 6-, 12- and 24-months post-infection. These children and young people reported around 5-to-6 symptoms at each time-point. 3/

Researchers used data from the Long COVID in Children and Young People (CloCk) study to describe symptoms and how much they impact children and young people’s lives 24-months post-infection. 2/

Most young people who were confirmed to have #LongCOVID 3 months after a positive PCR test had recovered within 24 months finds CLoCK study—the world's largest longitudinal cohort study on long COVID in children. 1/

Asthma attacks & COPD flare-ups (also called exacerbations) can be deadly. Every day in the UK four people with asthma & 85 people with COPD will tragically die. Both conditions are also very common. In the UK, someone has an asthma attack every 10 seconds 6/6

www.thelancet.com/journals/lan...

The benralizumab injection was administered by health care professionals in the study but can be potentially administered safely at home, in the GP practice, or in the Emergency Department. 5/

Benralizumab is a safe and effective drug already used to manage severe asthma. The researchers used the drug in a different way—at the point of an exacerbation—to show that it's more effective than steroid tablets, which is the only treatment currently available. 4/

Treatment with the #benralizumab injection took longer to fail, meaning fewer episodes to see a doctor or go to hospital. There was also an improvement in the quality of life for people with asthma and COPD. 3/

#Benralizumab is a monoclonal antibody which targets eosinophils to reduce lung inflammation. The new trial has found a single dose can be more effective when injected at the point of exacerbation compared to steroid tablets. 2/

First new treatment for Asthma in 50 years!
An injection given during some asthma attacks is more effective than the current treatment of steroid tablets, reducing the need for further treatment by 30%. The findings could be "game-changing" for millions of people with asthma! 1/

A new nasal vaccine against Whooping Cough!

The new vaccine combines the traditional pertussis antigens with an innovative adjuvant called T-vant, which boosts the body's immune response specifically in the respiratory tract. 1/

Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis Dietary fat drives the pathogenesis of atherosclerotic cardiovascular disease (ASCVD), particularly through circulating cholesterol and triglyceride-r…

Here is the link to the study👇

www.sciencedirect.com/science/arti...

Trans fats are preferred over Cis fats by SPT to synthesize long-chain sphingoid bases. Trans-fat-derived sphingomyelin is highly secreted from cells.
Trans fats promotes hepatic SPT flux, VLDL secretion & atherosclerosis. SPT inhibition reduces circulating VLDLs & atherosclerosis in mice 4/4

Here, using a combination of in vitro and in vivo metabolic tracing, dietary manipulations, pharmacological interventions, and physiological analyses, researchers have highlighted a functional role for serine palmitoyltransferase (SPT) in hepatic lipoprotein metabolism and ASCVD progression. 3/

Fortunately, this attention to cholesterol has prompted the development of cholesterol-lowering drugs called statins and lifestyle interventions like dietary and exercise regimens. But what if there's more to the picture than just cholesterol? 2/

Cholesterol may not be the only lipid involved in trans fat-driven cardiovascular disease!

A NEW study describes how another class of lipids, called sphingolipids, contributes to arterial plaques and atherosclerotic cardiovascular disease(ASCVD). 1/

Hi!