Enrico Sandro Colizzi

In case you missed it: our review titled "Spatial structure: shaping the ecology and evolution of microbial communities" is out! 🚨

Let me hit you with some highlights on why spatial structure matters. (and why you should care!)

Sharing is appreciated 🙏 🧵👇

doi.org/10.1093/fems...

That a tiny polymerase ribozyme exists is good news *especially* for metabolism-first models of OoL, because it makes it easier to picture genetic memory emerging gradually within a self-maintaining proto-metabolic system.

Spatial structure: shaping the ecology and evolution of microbial communities Spatial structure naturally emerges in microbial communities, shaping growth, interactions, and evolution, and revealing how microscale processes scale up

Most microbes don't live in shaking flasks; spatial structure shapes how microbes interact and evolve at every scale, as we discuss in our recent review @jeroenmeijer.bsky.social @simonvanvliet.bsky.social @bedutilh.bsky.social @bramvandijk.bsky.social and others
academic.oup.com/femsre/artic... 🧵👇

Bridging the gap from chemistry to life: discovery of a tiny RNA that can copy itself | MRC Laboratory of Molecular Biology Led by Edoardo Gianni, Philipp Holliger’s group in the LMB’s PNAC Division have identified a small self-replicating catalytic RNA (ribozyme), providing new ...

Have a look at the Insight on Research story on our Science paper www.science.org/doi/10.1126/... on the @mrclmb.bsky.social website: mrclmb.ac.uk/news-events/... including a great little animation from LMB VisLab.

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Great summaries of our paper www.science.org/doi/10.1126/... in Science: www.science.org/doi/epdf/10.... and New Scientist: www.newscientist.com/article/2515... and in the Science museum blog: blog.sciencemuseum.org.uk/in-the-begin...

New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/...
Outstanding work by @edogia.bsky.social

How did life arise from simple chemical building blocks?

New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.

Read more: mrclmb.ac.uk/news-events/...

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
1/n

Very nice review! Congrats to all the authors.

Spatial structure: shaping the ecology and evolution of microbial communities Spatial structure naturally emerges in microbial communities, shaping growth, interactions, and evolution, and revealing how microscale processes scale up

Wrapping up a productive week: very glad to have contributed to this review on how spatial structure shapes microbial ecology and evolution, led by @marcelbaecker.bsky.social, @bedutilh.bsky.social, @bramvandijk.bsky.social and many others. doi.org/10.1093/fems...

New year, new conferences! Consider submitting to the symposium on Fitness landscapes and Genotype-phenotype maps, linking computational and experimental approaches (organising with @n-martin.bsky.social; @dbajic.bsky.social invited spreaker) at SMBE (28/6-2/7)! Abstract deadline February 3rd!

Bottleneck size drives the evolution of cooperative traits in an aggregative multicellular myxobacterium Population bottlenecks shape the evolution of cooperative traits in Myxococcus xanthus through life cycle trade-offs. This study shows that stringent bottlenecks favor growth and sporulation, while re...

Very cool paper by Jyotsna Kalathera et al. from @iamsamayp.bsky.social 's-lab on

Bottleneck size drives the evolution of
cooperative traits in an aggregative multicellular
myxobacterium

just out @plosbiology.org

Congratulations to all coauthors.

journals.plos.org/plosbiology/...

Interior of Sainsbury Laboratory building showing experimental laboratories on left with floor-to-ceiling glass facing into the main central avenue with people walking on stairs and sitting at study boxes. Lots of natural light and views to the Cambrdge University Botanic Garden. Overlay text "Join SLCU" and logos and closing date of 15 January 2026.

🌱 2x David Sainsbury Career Development Fellowships at @slcuplants.bsky.social

Unique opportunity for early-career researchers to launch their own independent research programme in quantitative plant development, with generous support & world-class facilities.

www.cam.ac.uk/jobs/david-s...

Pyocyanin produced by Pseudomonas aeruginosa Creates Legacy Effects That Boost Antibiotic Resistance Evolution in Enterococci Polymicrobial infections are small communities of multiple interacting bacterial species. Interactions among constituent species may modify the growth of community members in the presence of antibioti...

New preprint:
www.biorxiv.org/content/10.6...

The fitness costs of reproductive specialization scale inversely with organismal size The evolution of reproductive specialization represents a fundamental innovation in multicellular life, yet the conditions favoring its evolution remain poorly understood. Here, we develop a populatio...

1/28 New preprint up, which I think is the best theoretical idea I've ever had. We asked a simple question: what are the costs of investment into non-reproductive somatic cells? Turns out these costs decrease with the *logarithm* of organism size!

www.biorxiv.org/content/10.6...

@wcratcliff.bsky.social and collaborators, congrats on this!
I am reminded by a paper by Solari and Ray Goldestein on the same topic: www.journals.uchicago.edu/doi/10.1086/...
I wonder what you think about it.

Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...

Extensive horizontal transfer of transposable elements shapes fungal mobilomes Romeijn et al. reveal that horizontal transposon transfer is widespread in fungi, contributing up to 70% of transposon content in some taxa. The authors uncover thousands of events across diverse line...

Extensive horizontal transfer of transposable elements shapes fungal mobilomes

@currentbiology.bsky.social by @jromeijn.bsky.social et al from @mfseidl.bsky.social

www.cell.com/current-biol...

A concrete step: what if all scientific output was required by law to be published in not-for-profit journals?
It might not fix everything (AI slop, impact factors and publish-or-perish would stay), but it would stop this huge tax-payer money drain, and maybe have positive downstream effects.

An obviously AI-generated figure with AI slop and fake text all over it, recently published in Scientific Reports.

Since AI slop is again all over Scientific Reports, a thread on the economics of grey-zone publishing.

Why does slop keep getting published? What does it mean for science? How can we stop this?

Background readings:
Understand the strain: tinyurl.com/2b6wxx5r
Stop the drain: tinyurl.com/3jfscscy

The evolutionary role of mutational robustness: theoretical insights Mutational robustness, the ensemble of mechanisms that allow organisms to maintain a stable phenotype despite genetic mutations, affects adaptive evol…

Excited to share our new review: The evolutionary role of mutational robustness: theoretical insights, in Trends in Genetics!
Our review distils the main theoretical insights into when robustness evolves and how it shapes evolvability.

www.sciencedirect.com/science/arti...

Cellular structure self-organizes through an interplay between internal mechanisms and external cues. The single-celled suctorian P. collini builds a trap structure to capture large prey using microtubule feeding tentacles, creating feedback between cell morphology and prey availability.

Nutrient availability affects optimal growth strategy in predatory DPANN | mSystems The bacterial and archaeal domains each possess a major clade that appears to be predominantly host-associated (1–3). These two lineages, Patescibacteriota and DPANN archaea (named for the Diapherotri...

Ever since publishing our observations of the predatory behaviour of Ca. Nha. antarcticus people have asked me why it would want to kill its host. My perspective discussing the ecological factors that I believe led to this behaviour is out now in mSystems:
doi.org/10.1128/msystems.01475-25

Let me use this as an opportunity to talk about Jordi et al's very cool paper, now out in PNAS 🧪:

pmc.ncbi.nlm.nih.gov/articles/PMC...

You can read our news and views here: www.pnas.org/doi/10.1073/...

Mycobacterium smegmatis Expands Across Surfaces by Hydraulic Sliding - Environmental Microbiology Reports enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/... - Our new paper is out!

#microsky #mevosky @spp2389.bsky.social

A PhD position is available in my lab to work on:

Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.

Please RT

Deadline: 12.11.25

More infos 👇
shorturl.at/rAKAT

Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

From polymicrobial water kefir grains to PCD in biofilms, microorganisms are magnificently multicellular!
Thanks to @embo.org @ibe-barcelona.bsky.social for having Lena Friebel and Thorsten Mascher @tudresden.bsky.social as well as @escolizzi.bsky.social at the
#Multicellverse workshop

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

Only a few days left to apply!

My group is looking for a postdoc to engineer and deploy new tools to precisely manipulate and decode how auxin coordinates plant morphogenesis.

@starmorph-syg.bsky.social

Research Associate - Reprogramming Development (closes 7 October 2025)