Mashek Lab

Interested in lipids? Join us @ the 2026 FASEB Lipid Droplet: From Mechanisms to Disease Conference (July 26-30, Scottsdale, AZ). Registration is now open!

events.faseb.org/event/Lipid-...

We are co-locating with the FASEB Phospholipids SRC! Register for one to enjoy BOTH meetings!

Fueling MASH: Metabolic Drivers and Inflammatory Crosstalk | Keystone Symposia Join us at the Keystone Symposia on Fueling MASH: Metabolic Drivers and Inflammatory Crosstalk, April 2026, in Vancouver, with field leaders!

Worked with a great team to organize @keystoneSymposia.bsky.social Fueling #MASH : #Metabolic Drivers & #Inflammatory Crosstalk, this April! Join us to explore emerging research in Vancouver! keysym.us/KSMASH26 #KSMASH26

Early Registration and Abstract deadline is in less than 2 weeks!

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

☕ @mikelangelipid.bsky.social @olzmannlab.bsky.social & co identify a #LipidDroplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of #ferroptosis.
@berkeleymcb.bsky.social
bit.ly/49mTeyF

Congrats! Groundbreaking work!

Quantitative imaging of lipid transport in mammalian cells - Nature Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

Quite a week for #lipidtime: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from @nadlerlab.bsky.social and colleagues is now out @nature.com! www.nature.com/articles/s41...

Congrats Judi!!!

Understanding the predictors of metabolic dysfunction-associated steatotic liver disease—

ASCI member Peter Crawford & team suggest ketogenesis serves a protective role in MASLD-MASH progression via processes other than fat oxidation: buff.ly/f26w63M

Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

These data are in agreement with www.nature.com/articles/s41... from @dremilygoldberg.bsky.social showing that HDAC1-3 can acylate proteins using fatty acids rather than their acyl-CoA derivatives as substrates. This raises many questions about epigenomic regulation via changes in metabolism.

Sorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expression of inflammation genes Sorbic acid regulates inflammatory gene expression through the mechanism of lysine sorbylation.

Super excited to share our new publication identifying the food preservative, sorbic acid, as a new PTM. Even cooler is that the deacylation and acylation of this PTM is catalyzed by the non-canonical activity of Class I HDACs using free sorbate (not sorbyl-CoA) www.science.org/doi/10.1126/...

Congrats. This is very cool!

We recently published
@geroscience.bsky.social
the development and validation of the mouse social frailty index (mSFI) link.springer.com/article/10.1...

We now report a detailed step-by-step resource paper describing how to conduct the mSFI.
bio-protocol.org/en/bpdetail?...

Congrats!!

Proud to share the work of my forst ever PhD student and first author of this paper @dylanduerre.bsky.social!! Here, he summarizes it perfectly! #brownfat #metabolism #BCAA #heme @uwmadison.bsky.social @uofutahcihd.bsky.social

Congrats! That is so cool. I hope you are getting some royalties….

What are 26 different Rab GTPases doing on Lipid Droplets? Are lipids transferred by membrane contact sites? Moving the FAT: Emerging roles of Rab GTPases in the regulation of lipid droplet contact sites M Alonso @albertpol.bsky.social and Harriet P Lo www.sciencedirect.com/science/arti...

Neutral lipids restrict the mobility of broken DNA molecules during comet assays This study reveals that neutral lipids (NL), naturally present in cells, become trapped within genomic DNA as a consequence of the standard execution of the comet assay, a technique used to measure D...

New from
@MorieLAB.bsky.social!
Neutral Lipids restrict DNA mobility!!
1. This has important implications for DNA repair in vivo,
2. also in vitro when you measure DNA breaks using the comet assay, beware!
3. And, we provide a fast new protocol overcoming this issue 😍

doi.org/10.1111/boc....

Can’t wait to read this. Congrats!

Soooo cool!