Carolina Cabalín

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@biorxivpreprint.bsky.social Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis
www.biorxiv.org/content/10.1...

@biorxivpreprint.bsky.social T Cell-Driven Mechanisms of Kidney Damage in Immune Checkpoint Inhibitor-Associated Acute Interstitial Nephritis
www.biorxiv.org/content/10.1...

IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions @cp-immunity.bsky.social
www.cell.com/immunity/ful...

A grey tabby cat is staring over his shoulder, white gleaming fangs on full display, as he hisses fearsomely

This Halloween I'm a vampire! 🧛‍♂️ hisss!!! Hisss! #HappyHalloween

A 37-color spectral flow cytometry panel to characterize phenotype and cytokine expression in human intestinal T cells https://www.biorxiv.org/content/10.1101/2025.10.29.685441v1

No one wants to do a postdoc anymore, they all want to rob the Louvre

It feels very meaningful to be closing the year this way. There has been so much dedication invested into both projects, and I really needed this boost of energy to remind myself that the data are strong, and that it's time to publish those papers! 😅

2. My PhD/postdoc work at UC on using vernix caseosa to treat atopic dermatitis, presented by Dr. Borzutzky at PAAM 2025, received the Best Short Talk Award in the Food Allergy & Dermatology category! 🏆🧴
So excited, especially with the mouse model validation 😍

1. In addition to enjoying the excellent and wonderful Montagna Symposium in Skin Biology thanks to the Molly Kulesz-Martin Director’s Award, I was also recognized for the poster presentation of my postdoctoral work at WCM, where we are studying the role of aPD-1 in skin irAEs 🔵

This week has been full of wonderful scientific news ✨👩🏼‍🔬

Fat cat Friday (I’m allowed to post again)

Ps. Hopefully next time Itai and Tim will give Chile 🇨🇱 another chance, and come back to give talks free of awkward moments 😅

It was wonderful to reconnect at the NYC Postdoc Night Science! Such a great and inspiring conversation about how to give better talks and tell science stories that matter

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

A human pan-disease blood atlas of the circulating proteome
@science.org @buenoalvez.bsky.social
www.science.org/doi/epdf/10....

😍😍

Congrats! 🥳

@biorxivpreprint.bsky.social TCR activation impairs CAR-T cytotoxicity against separate target cells
www.biorxiv.org/content/10.1...

Adiponectin to the rescue: extracorporeal photopheresis for managing immune checkpoint inhibitor-induced toxicities - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Adiponectin to the rescue: extracorporeal photopheresis for managing immune checkpoint inhibitor-induced toxicities

🚨New research highlight: study on managing immunotherapy side effects without weakening anti-tumor power!
ECP reduces harmful immune activity via neutrophils/T cells & promotes M2 macrophages via adiponectin.
Promising results from Zeiser et al. 🔬 🧪 🧫
Full summary:
www.nature.com/articles/s41...

Treg cells rule!

Interested in learning how to be a good speaker and give effective talks? Season 2 of the NYC Postdoc Night Science Club begins October 15th. Join us NYC Postdocs for a 2hr workshop and maybe also a drink at a bar! Free registration (usually ~100 come): docs.google.com/forms/d/1dII...

Cis-elements required for Blimp1-mediated Tcf7 repression in control of memory CD8 T differentiation, where decoupling Tcf7 silencing from effector differentiation is permissive for effector gene expression @cp-immunity.bsky.social
www.cell.com/immunity/ful...

S. aureus causes a basophil influx into skin-draining lymph nodes that heightens Th2 responses & increases serum IL-4, which enhances intestinal permeability, exaggerating oral anaphylaxis (dermatitis --> food allergy) @cp-immunity.bsky.social @harvardmed.bsky.social
www.cell.com/immunity/ful...

Big fan here as well! I feel like I get to see more articles than I normally would thanks to your posts! Thanks!!

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression - Nature Aging Bodogai et al. identify a unique subset of CD8+ T cells expressing CD39 and CD73 that accumulate during aging and are recruited to and actively promote tumor progression by suppressing antitumor CD4+ T cells. Targeting their function or recruitment attenuates tumor growth in aged mice.

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression @nataging.nature.com
www.nature.com/articles/s43...

NIH establishes nation's first dedicated organoid development center to reduce reliance on animal modeling The Standardized Organoid Modeling Center aims to produce standardized protocols for organoid research, addressing reproducibility challenges.

NIH establishes nation's first dedicated organoid development center to reduce reliance on animal modeling | National Institutes of Health (NIH) share.google/odgU3dnlWbTv...

An optofluidic workflow for isolating antigen-specific functional CD8+ T cells with or without a prior knowledge of peptide-MHC specificities @cp-iscience.bsky.social
www.cell.com/iscience/ful...

CD103 facilitates the interaction of naive CD8+ T cells with E-cadherin-expressing dendritic cells that in turn provide cytokine-mediated cues to promote their differentiation into memory-phenotype effector T cells @cp-immunity.bsky.social
www.cell.com/immunity/ful...

IFN-induced senescent CD8+ T cells mediate immunotherapy nonresponsiveness in early TNBC, which can be reversed by nicotinamide mononucleotide
www.science.org/doi/10.1126/...