Joshua Elkington

Let the Best Drug Win with Errik Anderson axial.substack.com/p/let-the-be...

Errik Anderson is the CEO and Founder of ⁠⁠Alloy Therapeutics⁠⁠. Founded in 2017, the company democratizes access to drug discovery platforms and services. In our conversation, we discuss Alloy's product offering and story

Alexion helped pioneer the rare disease business model. Their business was enabled by new technology (recombinant biology), new regulations (Orphan Drug Act), and better ways to acquire patients (close partnership with Leeds Hospital) axial.substack.com/p/axial-alex...

Focused on managing clinical data and communications for life sciences companies, Veeva pioneered the vertical Software-as-a-Service (SaaS) business model by building out one of the first industry-specific clouds.

Veeva axial.substack.com/p/axial-veeva

Veeva was founded in 2007 by Peter Gassner and Matt Wallach to make life sciences more efficient and bring new medicines to patients. The company is one of the most important case studies on how to build a standalone software business in life sciences.

Drugs that are their own pipelines axial.substack.com/p/drugs-that...

BridgeBio axial.substack.com/p/axial-brid...

Scientist Stories: Terry Orr-Weaver, Cell Division and Chromosome Segregation youtu.be/4OHiHK4GlSE

Scientist Stories: Sonja Schrepfer, The Future of Stem Cells and Hypoimmune Cell Therapies youtu.be/6sthpRhMZhg

Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins www.nature.com/articles/s41...

Deep Visual Proteomics defines single-cell identity and heterogeneity www.nature.com/articles/s41...

Founder Stories: Tassos Gianakakos, CEO of MyoKardia youtu.be/Haa6ORz__ig

The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection www.science.org/doi/10.1126/...

"It's not enough what I did in the past - there is also the future"

- Rita Levi-Montalcini, Nobel Prize winner for discovering nerve growth factor

KRAS is vulnerable to reversible switch-II pocket engagement in cells www.nature.com/articles/s41...

"We believe that the last person in the door is just as important as the first. We consciously reject the German model for the Silicon Valley model. We want the guy on the loading dock to be thinking about clinical programs."

- Joshua Boger, Founder & CEO of Vertex Pharmaceuticals

Founder Stories: Joshua Boger, Founder and CEO of Vertex Pharmaceuticals youtu.be/DdKVhpZ9Q4k

Human chimeric antigen receptor macrophages for cancer immunotherapy www.nature.com/articles/s41...

Worth a Read: 'Unexpected Effects of Protein Degradation' www.science.org/content/blog...

Accelerating high-throughput virtual screening through molecular pool-based active learning pubs.rsc.org/en/content/a...

Applying Bayesian optimization to the problem of HTS by constructing a surrogate model of the docking score of a ligand for a given protein target

Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development www.nature.com/articles/ncb...

With 2 approaches, the paper estimates that there are approximately 30 HSC clones that arise during development in zebrafish. Similar to estimates in other animals

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal and leukemia cells www.nature.com/articles/nm....

The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer www.cell.com/cell/pdf/S00...

Global profiling of phosphorylation-dependent changes in cysteine reactivity www.nature.com/articles/s41...

The paper studies how phosphorylation of proteins affects the reactivity of cysteine residues

Scientist Stories: Magdalena Zernicka-Goetz, Human Development and Synthetic Embryos youtu.be/2_cjdLb7adg

www.pnas.org/doi/abs/10.1... The paper introduces Botryllus schlosseri, a marine colonial chordate, as a model organism for the study of neurodegeneration. As well as the evolutionary origins of these processes

Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively www.biorxiv.org/content/10.1...

Identifying and overcoming the sampling challenges in relative binding free energy calculations of a model protein:protein complex led by Ivy Zhang from the John Chodera lab www.biorxiv.org/content/10.1...

Image-based cell sorting using focused travelling surface acoustic waves

Describes a new method for sorting cells based on their physical properties. Using a combination of real-time deformability cytometry (RT-DC) and focused travelling surface acoustic waves (FTSAW).

pubs.rsc.org/en/content/a...

"Everything is made from a chemical reaction. If you look around my office, everything is made from a chemical reaction."

- David MacMillan, Nobel Prize winner for developing asymmetric organocatalysis

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