I am looking forward to my visit and to sharing some of our recent work with QBI colleagues!

Genome rearrangements induced by the stimulation of end-joining of DNA double strand breaks through multiple phosphorylation of MRE11 by the kinase PKB/AKT1 Abstract. Genetic instability is a major hazard threatening the fate of cells and ultimately of organisms. DNA double-strand break (DSB) is a highly toxic

The hyper-activation of DNA double-strand break repair by the AKT1/PKB oncogene generates genetic instability.
(A new role for the oncogene AKT1: the phosphorylation of MRE11).
academic.oup.com/nar/article-...

CST Is Epistatic With Shieldin to Limit DNA Double‐Strand Break End Resection and Promote Repair During Igh Class Switch Recombination Here we show that CST and SHLD are required for CSR, while SHLD1-CTC1 interaction via the SHLD1 LDLP motif is dispensable. Mechanistically, we show that CTC1 and SHLD1 are epistatic during CSR, preve...

New publication from the lab. CST Is Epistatic With Shieldin to Limit DNA Double‐Strand Break End Resection and Promote Repair During Igh Class Switch Recombination - Lescale - 2025 - European Journal of Immunology - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....