Gladfelter Lab

RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

Also check out the News and Views by Ayse Ecer and Tatjana Trcek!

nature.com/articles/s41...

RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations.
www.nature.com/articles/s41...

@gladfelterlab.bsky.social kicking off the first SRC of 2026 with an amazing turnout at #PhaseTSRC. Special thanks to our organizers for their leadership in this brand-new conference topic, including lead organizer @umassmdlab.bsky.social

How can you tackle emerging questions in cellular organisation, adaptation, and robustness? Join #EESPhaseSeparation! 🧬🦠

Bringing together scientists from diverse fields to foster new discoveries in condensate biology.

Submit your abstract by 10 Feb: s.embl.org/ees26-08-bl

📅 19 – 22 May 2026

Interested in the MBL Physiology Course in Woods Hole and want to learn more before you apply?

Join myself and Cliff at our Virtual Open House TOMORROW 2–3 PM ET. You will hear what the course experience is like and get all your questions answered.

Register/Join: princeton.zoom.us/j/97673682905

Fantastic ASCB so far! Haven’t even had time to live tweet with all the great talks and catching up with folks. Some science standouts to far have been the Planetary Cell Bio session organized by @gladfelterlab.bsky.social and @robinsall.bsky.social’s beautiful talk on cell migration

Cells for Planetary Health Community Registration Form Following the “Integrating Cell and Planetary Scales to Address Climate Resilience” workshop held in Lisbon in April 2025, we’re launching a new community dedicated to bridging scientific disciplines ...

🌍 Heading to #CellBIO2025 meeting @embo.org @ascbiology.bsky.social ? Join us as we continue building Planetary Cell Biology, a cross scale field - from cells to biodiversity. Sunday, Dec 7 | 8:30–9:45 AM EST
Curious? www.youtube.com/@Cells4Plane...
🌱 Join the community: forms.gle/AjQ6dVBL7QT5...

#Lipid packing and local geometry influence #septin curvature sensing, say Brandy Curtis, Amy Gladfelter @gladfelterlab.bsky.social and colleagues @duke-university.bsky.social: rupress.org/jcb/article/...

#Biochemistry #Cytoskeleton

Lipid packing and local geometry influence septin curvature sensing Localization of the septin cytoskeleton is controlled by regulatory factors, membrane curvature, and charge. In this study, changes to lipid composition th

Delighted to share the latest chapter in the mystery series on how septins sense membrane curvature. Grateful to reviewers for thoughtful critiques and @jcb.org for publishing our work! doi.org/10.1083/jcb....

Our paper on the spatial organization of nuclear paraspeckles is out in #PNAS! Excited to see what comes next from the teams of @shrinivaslab.bsky.social and @sneadlab.bsky.social at Northwestern! pnas.org/doi/10.1073/pnas.2504778122

We are back! 🔬👩‍🔬👨‍🔬
Mark your calendars, TCM 2025 is happening September 15th at the Trent Semans Center! 🧠✨

Get ready for an incredible lineup of speakers including Dr. Kris DeMali, Dr. Rae Cho, and Dr. Stefanie Redemann.

🗓️ Registration opens July 7th, don’t miss out!

#TCM2025

Discover the wonder of the fungi in this latest issue of Current Biology 🍄 www.cell.com/curbio/issue...

Start of 2025 @mblscience.bsky.social Physiology course! This is the second year of Amy @gladfelterlab.bsky.social and I co-Directing this absolutely amazing and life-changing course: www.mbl.edu/education/ad...

Amazing start to EMBO workshop Cells4Climate resilience>>https://meetings.embo.org/event/25-climate-resilience>>day 1 energy captured here youtu.be/KFRFSPHdjFM

🌍🔬 📣 Please spread the word! Join us!
How can cell biology shape a more resilient planet?
Virtual registration is still open for the EMBO Workshop on Cells 4 Climate Resilience → meetings.embo.org/event/25-cli...
🗓️ Deadline: April 11
🎥 Watch the teaser → youtu.be/8eMJ91udHDs
@embo.org

What a wonderful time catching us with @meghanriddell.bsky.social in Charolette at the Society for Reproductive Investigation Annual Meeting!

Cell biology meets climate resilience – a call to action The molecular and cellular biology community has always been driven by a fascination with mechanisms – how proteins interact, how organelles communicate and how cells respond to stimuli. Yet one of th...

Mónica Bettencourt-Dias @monicabettencourt.bsky.social, Amy Gladfelter @gladfelterlab.bsky.social, Gautam Dey @gautamdey.bsky.social Samara Reck-Peterson @samreckpeterson.bsky.social @cells4planethealth.bsky.social @embo.org share a call to action to apply the lens of #cellbio to climate challenges.

Immiscible proteins compete for RNA binding to order condensate layers Biomolecular condensates mediate diverse and essential cellular functions by compartmentalizing biochemical pathways. Many condensates have internal subdomains with distinct compositional identities. ...

Excited to share our first story on nuclear paraspeckles! Led by @sneadlab.bsky.social, this is the culmination of a ~4 year effort in collab. with @shrinivaslab.bsky.social. Can’t wait to see more paraspeckle stories from the future Snead Lab at Northwestern 🫧 www.biorxiv.org/content/10.1...

Cooperativity in septin polymerization is tunable by ionic strength and membrane adsorption Cells employ cytoskeletal polymers to move, divide, and pass information inside and outside of the cell. Previous work on eukaryotic cytoskeletal elements such as actin, microtubules, and intermediate...

The mysteries of septins continue to unfold in this study examining mechanisms of septin polymerization and assembly! www.biorxiv.org/content/10.1...

Lipid packing and local geometry influence septin curvature sensing Septins assemble into scaffolds that direct cell growth and morphology that are often localized to the plasma membrane. While septins preferentially bind convex membranes via amphipathic helices, thei...

We are excited to share our next installment of insights into how septins sense micron-scale curvature via detecting lipid packing! www.biorxiv.org/content/10.1...

Change your life! Physiology course application deadline is extended to February 3rd! Apply now for a summer of discovery at MBL!

Integrating cell and planetary scales to address climate resilience The climate crisis is a multiscale problem that requires transdisciplinary expertise for understanding and engineering climate resilience. Cells are the first responders of the biosphere and yet cell…

The deadline for @cells4planethealth.bsky.social has been extended to February 1st- register now! meetings.embo.org/event/25-cli...

Physiology: Modern Cell Biology Using Microscopic, Biochemical and Computational Approaches | Marine Biological Laboratory This course is at the forefront of new tools — molecular, computational, biophysical — as it prepares students to tackle emerging biological questions.

The deadline to apply for the MBL Physiology course is fast approaching, January 27th! Consider applying to this amazing, life-changing research discovery experience in Woods Hole! www.mbl.edu/education/ad...

Integrating cell and planetary scales to address climate resilience The climate crisis is a multiscale problem that requires transdisciplinary expertise for understanding and engineering climate resilience. Cells are the first responders of the biosphere and yet cell…

📢 Dive into topics like cell biology in changing environments, microbial ecology, and climate adaptation strategies for planet and human health at the EMBO Workshop in Lisbon! 🌱
🗓️ April 13–16, 2025 | Lisbon, Portugal
Secure your spot: meetings.embo.org/event/25-cli...
#CellBiology #PlanetaryHealth

Two weeks left to apply for this year's Physiology Course! We are looking forward to another exciting summer 🔬🦑☀️

Negative feedback equalizes polarity sites in a multi-budding yeast Morphogenesis in fungi and animals is directed by polarization of small GTPases Cdc42 and Rac. In the budding yeast Saccharomyces cerevisiae competition between polarity patches results in one polariz...

New work lead by graduate student Alex shows how concerned signaling networks can be modulated for distinct morphogenic programs even within the constraints of fungal budding! www.biorxiv.org/content/10.1...

RNA encodes physical information Most amino acids are encoded by multiple codons, making the genetic code degenerate. Synonymous mutations affect protein translation and folding, but their impact on RNA itself is often neglected. We ...

Thrilled to share our recent work on the power of RNA to encode physical information and how this can be embedded in the genetic code
www.biorxiv.org/content/10.1...

Condensates act as translation hubs to coordinate multinucleate cell growth Coordination between growth and division is a fundamental feature of cells. In many syncytia, cell growth must couple with multiple nuclear divisions in one cytoplasm. In the fungus, Ashbya gossypii, ...

Excited to share the latest work from postdocs Ameya
and Zach! We thought about how multinucleate cells are able to maintain N:C ratio, and found a condensate rheostat that regulates translation of cell cycle + growth mRNAs. Check it out! www.biorxiv.org/content/10.1...