Eugenio F. Fornasiero

We used it in several super-resolution imaging modalities

There is a pH-sensitive version for SV recycling

We were able to use if for interactome analysis and LC-MS/MS

It localizes correctly to synaptic vesicles

It is specific and works in human cells

We designed and customized several versions

Nanobinders for Synaptotagmin 1 enable the analysis of synaptic vesicle dynamics in rodent and human models. Synaptic neurotransmission is a critical hallmark of brain activity and one of the first processes to be affected in neural diseases. Monitoring this process, and in particular synaptic vesicle recycl...

Excited for our latest work! We developed nanobinders for the luminal domain of Synaptotagmin 1 (calcium sensor for synaptic vesicles). Thanks among others to @verstrekenlab.bsky.social @opazo.bsky.social @meunierlab.bsky.social @volkerhaucke-lab.bsky.social www.biorxiv.org/content/10.1...

Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to juan.bonifacino@nih.gov. Please share and repost!

Harsha (@har.bsky.social) ⒸⓄⓃⓃⒺⒸⓉ ⒸⓄⓁⓁⒺⒸⓉ ⒸⓇⒺⒶⓉⒺ | 0xharsha.eth | Experimenting with Dummy Degen (crash test dummy character) to journal our web3 journey!

DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning

@boazmohar.bsky.social har.bsky.social @rhodamine110.bsky.social mine110.bsky.social @forna.bsky.social @hhmi.org

www.nature.com/articles/s41...

Thanks to @eduardunterauer.bsky.social, @jekristina.bsky.social, @forna.bsky.social, @opazo.bsky.social and @carstenmarr.bsky.social for putting together this great step-by-step guide on how to achieve up to 30-color DNA-PAINT spatial proteomics at sub-15 nm resolution. 🚀

🚀 Thrilled to share our latest research! With the labs of Yansheng Liu and Junmin Peng we’ve built the largest in vivo protein turnover resource across multiple tissues and brain regions, now published in Cell @cellpress.bsky.social 🔬💡 #Proteomics Check it out! 👇
authors.elsevier.com/c/1koBJL7PXu...

Sonoepigenetics: Spatiotemporal Calcium Dynamics and cAMP Signaling Driven by High Frequency Nanomechanostimulation Regulates Transient Epigenetic Modifications and Early Osteogenic Commitment in Mese... Cells effectively balance and integrate numerous pathways to adapt to external signals in an attempt to regain homeostasis, although the complex nuclear mechanotransduction mechanism through which thi...

I am Absolutely delighted to share the preprint of our last collaborative efforts where we investigated the impact of sonostimulation of Mesenchymal Stem Cells. Thread -1-

www.biorxiv.org/content/10.1...

🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains.

Read more: e11.bio/news/roadmap

With Ben Cooper I am excited to announce the 8th Schram Foundation Symposium (Göttingen 25th of March 2025 as a satellite of the German Neuroscience society). It is free of charge and we have distinguished speakers including @alex-filosa.bsky.social and @pawelburkhardt.bsky.social. Please circulate!

SUM-PAINT that our lab developed with a massive collaborative effort with the Jungmann and the Opazo lab represents a unique way to image in parallel 30 or more proteins at ~15 nm spatial resolution www.sciencedirect.com/science/arti...

CZI Neurodegeneration Challenge Network Projects We’re proud to support research that aims to advance the study of neurodegenerative disease and accelerate progress toward cures.

I am very excited and grateful to be one of the pairs of collaborators funded by the CZI Neurodegeneration Challenge Network, which will allow me to start a new project with one of my favorite scientists: Giordano Lippi at Scripps!

Interested in a #PhDposition, fully funded in #Genome Science? For example the project of @CyganekLukas @yourUMG. Deadline is January 26. #CRISPR #omics #MolecularBiology More information here: uni-goettingen.de/de/556628.html

2024 start off on the right foot: our preprint on the repurposing of a small molecule inhibitor to induce rapid, synchronous and SASPless senescence to human cells is now out in Aging Cell! A multi-lab effort led by former PhD student S. Palikyras

onlinelibrary.wiley.com/doi/10.1111/...

Are you a cell biologist interested in nanoscale fluorescence imaging?

Check out our new review in Trends in Cell Biology:
www.sciencedirect.com/science/arti...

Thanks and kudos to all authors: Elisa DʼEste, Gražvydas Lukinavičius, Felipe Opazo and @rlicolnchemist.bsky.social