Condensate-Driven Triglyceride Depletion Links α-Synuclein to Mitochondrial Dysfunction
Inclusions of α-Synuclein (αSyn) characterize multiple age-related neurodegenerative diseases, including Parkinson’s disease (PD) and Multiple System Atrophy (MSA). While interactions between αSyn and...
🚨 New preprint alert! We uncovered a link between Parkinson’s protein α-synuclein and fat metabolism. α-syn inclusions disrupt lipid droplets and deplete TAGs during aging & MCFAs restore movement in α-synuclein worms.
👉 Targeting fat metabolism could help to combat Parkinson’s! shorturl.at/2mVG6
21.11.2025 08:15 —
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Excited to announce that Suzanne Couzijn and Anna Ainslie have received a grant from Stichting ParkinsonFonds🎉👏 for their project “Protecting against alpha-synuclein toxicity at molecular and physiological levels”. They will investigate the mechanisms driving alpha-synuclein toxicity in C. elegans🪱🧠
28.08.2025 09:04 —
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Congratulations Jamil!
11.02.2025 13:53 —
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We’d love to connect with researchers, advocates, and anyone curious about the biology of ageing and neurodegenerative diseases! 💬
09.01.2025 12:06 —
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We’re the Nollen Lab, and we’re excited to join the scientific community on Blue Sky!🌞 Our lab uses the nematode worm C. elegans to understand the molecular neurobiology of ageing and neurodegerative diseases 🧠🔬🧪🪱
#Neurobiology #AgingScience #Parkinsons #ALS #Alzheimer #Metabolism #Ageing #Celegans
09.01.2025 12:06 —
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