"Premature optimisation is the enemy of progress!" I shout as I submit yet another half-baked vibe coded PR
27.02.2026 23:33 — 👍 2 🔁 0 💬 0 📌 0"Premature optimisation is the enemy of progress!" I shout as I submit yet another half-baked vibe coded PR
27.02.2026 23:33 — 👍 2 🔁 0 💬 0 📌 0
Pretty wild Ai result, that will probably get less press than the latest Ai boyfriend article: arxiv.org/abs/2602.21201
A benchmark was created with professional mathematicians, using problems naturally encountered in their research and not publicly released. Aletheia solved 6/10 autonomously.
We (PYC Therapeutics) are hiring two biostatisticians, one senior, one junior
www.seek.com.au/job/90561321...
and
www.seek.com.au/job/90560959...
We need people who can give us confidence in rare disease diagnostics with small n!
#biostatistics
Outcomes for full apps won’t arrive until “15 Jan – 15 April” next year according to ARC’s new schedule – that’s up to 16 months since the EOIs were submitted 🤯
▶️ www.arc.gov.au/funding-rese...
#ERGAReads | 🐚 🌊 🧬 Ocean Genomes: reference genome resources for marine vertebrates
rdcu.be/e25OP
OpenAI is a menace. Two recent stories make that clearer than ever.
One day you have Sam Altman denigrating humanity to defend AI. The next, WSJ reveals OpenAI could have alerted Canadian police of a potential mass shooter, but refused pressure from employees. That person went on to kill 8 people.
As a teenager I was obsessed with conspiracy theories, I now think because in conspiracies, the people running the show are good at what they do.
But these days I'm learning that the power in the shadows is as garbage as everyone else
I remember when Humankapital (human capital) was voted worst German word. True
22.02.2026 05:44 — 👍 1 🔁 0 💬 0 📌 0My phone knows my age because it just auto-replaced "instagram" by "installation"
22.02.2026 04:55 — 👍 1 🔁 0 💬 0 📌 0
There's an image of people, of ourselves as a species, behind this statement that I find disgusting to my core.
He thinks humans are purely automatons to extract value from, and I'm sure that's the majority view of his social class.
Annotating genomes at increased scale and resolution
www.nature.com/articles/s41...
An agentic system for rare disease diagnosis with traceable reasoning
www.nature.com/articles/d41...
Surprisingly accurate!! I guess there's a long tail of information, especially in rare diseases, where the literature exists but physicians are unlikely to have encountered the papers
❤️said NO to yet another thing I was doing forever and nobody was paying me for ❤️
19.02.2026 04:24 — 👍 10 🔁 0 💬 0 📌 0
I'm finally on level D salary and with three dependents I might as well be back on my phd scholarship. Always one unexpected cost away from scrounging to pay rent.
"Real wages have gone backwards. Even earning $100,000 isn’t what it used to be"
theconversation.com/real-wages-h...
350 seems to be the average for kids sports clubs! Which is also way too much if you think about it - what does that pay?
16.02.2026 13:34 — 👍 2 🔁 0 💬 1 📌 0
BarleyGVDB: A Comprehensive Barley Variome Database for Population Evolution and Molecular Breeding Research in Barley
onlinelibrary.wiley.com/doi/full/10....
Trying to sign up my 7 year old for soccer - they want $971 per season. How am I supposed to afford that
16.02.2026 12:09 — 👍 4 🔁 0 💬 2 📌 0
'To run your locally installed version of Prettier, prefix the command with npx , yarn exec , pnpm exec , or bunx'
they have played us for absolute fools
Short musings on "cognitive debt" - I'm seeing this in my own work, where excessive unreviewed AI-generated code leads me to lose a firm mental model of what I've built, which then makes it harder to confidently make future decisions simonwillison.net/2026/Feb/15/...
15.02.2026 05:22 — 👍 465 🔁 88 💬 42 📌 20Most unimpressive/boring thing about the international far-right is how much they copy each others' homework. Not a single new idea, not a single invented concept. The dumbest people run the show.
15.02.2026 06:22 — 👍 5 🔁 1 💬 0 📌 0
Spiderman pointing at spiderman
The AI-generated code review is criticising the AI-generated pull request
14.02.2026 04:18 — 👍 3 🔁 0 💬 1 📌 0
Happy birthday to one of my favourite haters, Charles Darwin
12.02.2026 16:31 — 👍 10351 🔁 3083 💬 162 📌 419
when the README on github looks like this you KNOW the pipeline hasn't been updated in >2 years
13.02.2026 07:02 — 👍 1 🔁 0 💬 0 📌 0
the most annoying (of many) things of this AI/copilot integration in Positron is when the AI integration is faster than the file-system integration, so you get an AI-hallucinated file path (always wrong) far faster than the real file on your filesystem
12.02.2026 02:50 — 👍 4 🔁 0 💬 1 📌 0Or, like depression! Gradually, then suddenly
11.02.2026 01:20 — 👍 1 🔁 0 💬 0 📌 0we invented literate programming so you don't write English text around your code blocks
11.02.2026 01:18 — 👍 0 🔁 0 💬 0 📌 0
Love having this kind of brain-brokenness where I spend 20 minutes looking for my phone, not remembering where I put it, only remembering thinking "haha what an unusual place to put the phone"
(It was on top of the children's clothes drawer)
Neither email nor SMS based password reset works so I guess we'll never know what they want from me
10.02.2026 11:55 — 👍 0 🔁 0 💬 1 📌 0
The dreaded myGov inbox email
They know when I'm getting too relaxed. That's why they send these at 6:33pm
10.02.2026 10:40 — 👍 1 🔁 0 💬 1 📌 0
Haven't seen a plant pangenome in Science for a while!
www.science.org/doi/abs/10.1...
Eleven T2T genomes + 1720 accessions sequenced