Nunes Augusto ✌️ 🇵🇸 🇧🇷 😷 💉

YouTube video by Jones Manoel Meta derrubou minhas redes sociais

Camaradas, nesse vídeo, dentre outras coisas, divulgo toda minha agenda de atividades dos próximos dias. Ajudem a circular ao máximo, por favor.

youtu.be/1Bjj8FSh9Nw?...

Here’s a structured summary of the main findings and insights from the article “A methylation clock model of mild SARS‐CoV‐2 infection provides insight into immune dysregulation” published in Molecular Systems Biology: ________________________________________ 🧬 Key Findings 1. Persistent Epigenetic Changes After Mild SARS-CoV-2 Infection • Both asymptomatic and mildly symptomatic infections induce similar DNA methylation changes, even when gene expression returns to baseline. • These methylation changes persist for months, resembling patterns seen in autoimmune and inflammatory diseases. 2. Methylation Clock Model • Researchers developed a machine learning model using methylation data to: o Distinguish between pre-, during-, and post-infection states. o Accurately predict time since infection. • The methylation clock revealed distinct temporal clusters of methylation changes, each associated with specific immune cell types and transcription factors. 3. Anti-Protective Epigenetic State • Contrary to the concept of trained immunity, the post-infection methylation state was found to be anti-protective: o Individuals with a pre-infection methylation pattern resembling the post-infection state had higher viral loads and worse outcomes. o This state was not induced by BCG vaccination, suggesting it is distinct from known protective epigenetic responses. ________________________________________ 🔍 Comparative Insights 4. Overlap with Other Diseases • The post-SARS-CoV-2 methylation signature showed significant overlap with: o Systemic Lupus Erythematosus (SLE) o Chronic infections (e.g., HIV, Hepatitis C) • No significant overlap was found with asthma, allergies, or tuberculosis. 5. Age and Epigenetic Vulnerability • The post-infection-like methylation state increased with age, suggesting cumulative immune challenges may predispose individuals to less effective viral suppression. ________________________________________ 🧠 Conceptual Implications 6. Epigenetic Memory o…

Even mild or asymptomatic SARS-CoV-2 infections can leave a lasting imprint on the immune system—one that may resemble patterns seen in autoimmune diseases and chronic infections.

This challenges the assumption that recovery from mild illness is complete.
www.embopress.org/doi/full/10....

🫢🤭 "Ces não sentem vergonha? Nenhuma?"

Erika Hilton (PSOL-SP) debocha de um deputado bolsonarista com fita na boca na tarde de ontem na Câmara dos Deputados.
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📽 Acesso Erika Hilton via IG

Foto do vulcão Monte Lewotobi Laki-Laki na Indonésia. Foto: Indonesia's Geological Agency / AFP

Com a erupção do vulcão Monte Lewotobi Laki-Laki na Indonésia, tem rolando desinformação sobre vulcões - e vinda de um perfil grande. Então acho importante falar sobre isso

Os vulcões emitem muito CO2, logo, seriam mais responsáveis pelo aquecimento global do que o homem?

Não!!!!!

Vem entender 👇

Se vocês virem alguém falando besteira sobre o vulcão soltar muito mais dióxido de carbono na atmosfera do que a ação humana, leiam esse fio da @karilimax.bsky.social pra entender como isso não faz sentido.

E sigam ela, caso ainda não sigam!

Please help Dr Farahat and his family friends. Please donate to his campaign below and boost, every little bit makes such a difference!!
tinyurl.com/SupportFarha...

Sabre Doar faz bem e você faz a diferença! Conheça minha vaquinha: Sabre

Eu não queria fazer isso mas infelizmente aconteceram várias coisas, além de eu perder um emprego depois de ter tido uma crise de ansiedade, então criei uma vaquinha pra quem quiser ajudar com os valores abertos do apartamento que hoje moro e provavelmente vou ter q sair
www.vakinha.com.br/5606974

Grande reportagem no #Fantástico sobre a fome em Gaza, com relatos de pessoas no terreno e de especialistas, incluindo o jornalista palestino Rami Abou Jamous e @thibautbruttin.bsky.social

Donate to Support the Al mubasher Family's Journey to Safety, organized by Suzanne Barhoum Hello dear friends, My name is Haneen Awad, a Palestinian from … Suzanne Barhoum needs your support for Support the Al mubasher Family's Journey to Safety

Haneen @naeemafamily.bsky.social a 6 enfants : Naeema (22 ans), Mumen (17 ans), Abdul Rahman (14 ans) et les jumeaux Elias et Elan (9 ans)

elle m'a écrit qu'elle se sent impuissante et dévastée car elle ne peut pas fournir un abri à ses enfants

Help Haneen and her family, every little helps. Don’t allow Bluesky to shut down accounts of people from Gaza.

bsky.app/profile/naee...

hello @mommunism.bsky.social & @alexwinter.com
please help Haneen by repost, her campaign is going slow and she needs donation for feeding her children + they're sleeping in the street, they have no tent

Their campaign is here if you want you want to send some funds their way to help: bsky.app/profile/naee...

svp faites un don si vous pouvez
repartagez leur post

je repartage la cagnotte de Haneen et sa famille, avec qui j'échange par message
iels n'ont pas reçu beaucoup de dons et dorment dans la rue

svp donnez si vous pouvez
repartagez leur cagnotte

je repartage encore la cagnotte de Haneen et sa famille
elle a reçu quelques dons ces derniers jours mais c'est trop peu pour trouver un abri et se nourrir (il faut prendre en compte les frais de transaction de gofundme)

donnez si vous pouvez
repartagez/commentez son post

www.gofundme.com/f/support-th...

www.gofundme.com/f/support-th...

🍉

Haneen est toujours dans la rue avec ses enfants et sans tente, ils ont juste des couvertures par terre pour dormir
hier elle m'a écrit qu'il y avait des bombardements pas loin de là où elle est avec sa famille - l'endroit n'est pas sûr

donnez si vous pouvez
repartagez/commentez leur post

naeemaさん✨

je repartage la cagnotte de Haneen et de Naima

donnez si vous pouvez
repartagez leur post
commentez leur post, c'est toujours encourageant pour les gens à Gaza de voir qu'iels ne parlent pas dans le vide

please help the Al mubasher family if you’re able and share this post. 🩵