Sam Joseph

You’ve heard of #Lymedisease, but have you ever seen the bacteria that causes it? 🦠 Borrelia burgdorferi, the spiral-shaped culprit transmitted by ticks, swims with a creepy wriggling motion and uses #chemotaxis to navigate. Both fascinating... and disgusting #Microsky 🧪 #IDsky @shawlab.bsky.social

Next week, Scripps Research scientists Amy Lightner, Michael Bollong & Arnab Chatterjee will speak at #IBDCuttingEdge2025, sharing insights on regenerative medicine, clinical trials, and drug discovery in IBD.

Join us next week, Sept 19–21 | 📍 Coronado, CA
🎟️ Register now: ow.ly/xPsK50VFU8L

Ruin any book by adding "Tom Clancy's" to the title.

Tom Clancy's Protective Groups in Organic Synthesis

Gas Phase Separation of Modified Peptides for Activity-Based Protein Profiling Profiling the reactivity of the proteome with amino-acid level resolution requires the identification and quantification of reacted peptides in the presence of abundant unmodified peptides. Affinity-b...

An inspiring paper by the group of Jacob Geri in Analytical Chemistry. They present a method for residue-specific #chemoproteomics without the need for an enrichment step. To achieve this, they developed reagents that shift the ion mobility for gas phase separation. pubs.acs.org/doi/full/10....

Ultra-sensitive metaproteomics redefines the dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal diseases www.nature.com/artic...

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#proteomics #prot-paper

Probing the proteome Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. Can it deliver a new generation of drug targets?

Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. A feature in Nature Biotechnology explores whether it can deliver a new generation of drug targets. 🧪

PNGaseL from Flavobacterium akiainvivens targets a diverse range of N-glycan structures PNGases are used by a wide range of organisms to remove N-glycan structures from proteins for use as either nutrients or in glycoprotein processing. PNGaseF is the most well-characterised enzyme of th...

Very pleased to present the next pre-print from our lab #glycotime We showcase PNGaseL from Flavobacterium akiainvivens that we hope will be a useful tool for the glyco community 🍬🧪👩‍🔬 Special shout out to @cassiebakshani.bsky.social and Paulina (Ludger)
www.biorxiv.org/content/10.1...

Biblically accurate nitrogen

A "cross-decoupling" or "retro-Suzuki" sequence

Fans of Guenther Schlonk will enjoy the "cross-decoupling" easter egg:

jabde.com/wp-content/u...

Checking USCSB quarterly is one of my favorite hobbies

Are you really a synthetic chemist if you aren't watching USCSB videos?

Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn.

I felt I had to interrupt to respond...

Yikes

Exciting news: We have released #FragPipe 23, and it's one of our biggest updates ever. Windows installer, support for TMT on Astral and timsTOF, TMT35, PTM site reports for DIA, improved Astral data handling in #MSFragger, improved diaTracer for diaPASEF data, better Skyline integration, and more!

Excited to announce that I passed my 2nd year qualifying exam! This is where the fun begins…

If u ever had to depict proteins as schematics in papers, u know the dilemma: how to create a pretty “blob”?
If structure ends up big & central, u’ll render it with PyMol et al, but for a truly schematic depiction u want a biorender-style icon, but for YOUR protein.
Think I’ve finally found a way.

The 15th International ABPP Meeting will be happening in Leiden in 2027. While it is still a long way to go, if you enjoyed this year's edition or were sad that you missed out, make sure to already follow @abpp2027.bsky.social to receive all the information in the future!

Self-assembled PROTACs enable glycoproteins degradation in the living cells We report here a two-component proteolysis targeting chimeras (PROTACs) strategy selectively targeting O-GalNAcylated and O-GlcNAcylated proteins for proteasomal degradation, which leads to severe tox...

Great to see the new concept of protein PTMs functionalization published in @chemicalscience.rsc.org! The GlyTACs enable selective degradation of glycoproteins in living cells. Congratulation to Haoyu and Liu. Have a look on the full story here: pubs.rsc.org/en/Content/A... #chembio

is.... that a capybara for scale

Had a fantastic time at #ABPP2025, my first ABPP meeting. Saw outstanding talks, shared what I’ve been working on, and was proud to see my undergrad, Abbey Pitts, win best poster award. Keep an eye out for her, she’ll be applying to PhD programs this Fall. Can’t wait for ABPP 2027!

Did you enjoy the amazing #ABPP2025 meeting? Or were you sad that you could not attend?

If so, we are happy to announce that the next iteration of the meeting will happen in beautiful Leiden in The Netherlands in 2027. Keep an eye on this space, to be the first one to learn more. (1/2)

Engineering Life's Future with Synthetic Biology Bryan Dickinson highlights the impact of chemists in synthetic biology in special issue of Chemical Reviews

Chemists aren't just in labs; they're building the future of biology. In an introduction to a special issue of Chemical Reviews, Prof Bryan Dickinson describes how chemists are engineering everything from drug-producing microbes to virus-fighting phages. chemistry.uchicago.edu/news/enginee...

a cartoon of homer simpson holding a card ALT: a cartoon of homer simpson holding a card

I am not going to call this a Bluetorial, because I do not want to sully that term (which, at least I, find joyful).

Let’s call it a Orwellial.

Bad news — the effective freeze at the NIH’s Center for Scientific Review hits a major chemical biology study section. Not good. @jeremymberg.bsky.social

*Reaxys

Meme Image of sleepy person captioned "8 hours of study" Image of person locked in "8 hours of fucking around on scifinder" In the background there is an image of Kamala Harris as a hyena

Screening activators war of the worlds style

Chemical Formulas xkcd.com/3040

14th International Activity Based Protein Profiling (ABPP) Meeting on LinkedIn: REGISTRATIONS DEADLINES UPDATE! Early Bird registration (🐣) has been… REGISTRATIONS DEADLINES UPDATE! Early Bird registration (🐣) has been extended to the 30th of January and Late Registrations (🦉) end on the 28th of February…

If you are interested in 𝗔𝗰𝘁𝗶𝘃𝗶𝘁𝘆-𝗕𝗮𝘀𝗲𝗱 𝗣𝗿𝗼𝘁𝗲𝗶𝗻 𝗣𝗿𝗼𝗳𝗶𝗹𝗶𝗻𝗴, definitely consider the #ABPP2025 conference on March 30th to April 2nd, 2025, at The Francis Crick Institute.
Registration deadlines have been updated.
www.linkedin.com/posts/14th-i...

Super excited to finally share PANCS-Binders: our group's decade-long quest to accelerate protein binder discovery.

TLDR: PANCS-binders is fast (2 days), cheap (pennies), has extremely high fidelity (low false positive and negatives), and high-throughput.

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