Dr Róisín McManus

📧 Do contact me directly if you have any questions about this role or our work: roisin.mcmanus@dzne.de

Master student (f/m/x) in the field of Neuroimmunology 1447/2025/6

🥼 We’re looking for a #MSc student to work in our lab as part of their MSc thesis or internship on an interdisciplinary project @dzne.science, in Germany!

🧠 If you’re interested in #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad👇

jobs.dzne.de/en/jobs/1014...

Transposon-Display of AI-designed binders enables manipulation of the proteome in human cells Transposon-Display is a highly scalable screening method that links proteins to their encoding DNA during expression in E. coli via a mutant transposase. Leveraging this system, we identified AI-desig...

Can AI-designed binders degrade, aggregate, stain and enrich endogenous proteins in human cells? Check out our new preprint!
www.biorxiv.org/content/10.1...

📧 Do contact me directly if you have any questions about this role or our work: roisin.mcmanus@dzne.de

PhD student (f/m/x) in the field of Neuroimmunology 1439/2025/5]

📢 We are #hiring a #PhD student to work on an interdisciplinary, collaborative project @dzne.science in Bonn, Germany!
🧠 If you’re interested in western diet-induced #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad below 👇

jobs.dzne.de/en/jobs/1014...

Had a great time visiting @tcddublin.bsky.social last week where I got to share some of our new work from the lab! 🧠
Really enjoyed the discussions and meeting many amazing researchers, including some old friends 😊
Thanks to @David Loane and the TCD Biochemical society for the lovely invitation

Thrilled to be at #ADPD2025 in Vienna ☀️
Thanks to everyone who came to our session on innate immunity yesterday! Really enjoyed the discussions after on our findings on #metabolism & #microglia function in #alzheimer’s disease
I’ve learned a lot at this meeting - looking forward to Copenhagen 2026 🧠

N n m KMn

Q

Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin Xie et al. show that intermittent fasting (IF) enhances sexual behavior in male mice by reducing serotonergic inhibition through lower brain tryptophan. While IF does not improve endocrine function or...

Intermittent Fasting Increases Sex Drive in Male Mice: An Approach for Low Libido in Humans? Current findings could point the way for new therapy option / Serotonin plays key role.

Hot off the press from our Bonn based group of Dan Ehninger.

👉 www.cell.com/cell-metabol...

Thanks to @dzne.science @immunosens.bsky.social @alzassociation.bsky.social @jpnd @dfg.de @sfb1454.bsky.social for supporting our research!

This month the McManus lab turns 1! 🎉

It’s been an amazing year, from starting out with an empty lab space to having our first co-authorships, grant awards and successful student projects 📄

Delighted to work with such a wonderful team of scientists on #alzheimersdisease and #dementia research 🧠

Visit the #exhibition "What the Health - One World. Your Health!" at the Museum Koenig in #Bonn.

Check out the #events surrounding the exhibition and discover how your health and the health of the planet are connected 🌍

Learn more about the program here: bonn.leibniz-lib.de/de/ausstellu...

🚨 Apply now! We invite you to apply for this year's International School of Advanced Immunology taking place September 14 - 19 at Maria Laach, Germany.

Visit our website for more information: www.advanced-immunology.net

#international #school #immunology

Happy St Patrick’s Day!
And what a lovely surprise from the lab, who all wore green this morning ☺️☘️

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...

I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.

I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social

Check out the latest episode from @immunosens.bsky.social where I chat about our research on #microglia, #NLRP3 and immunometabolism in #Alzheimer’s disease that was published this month in @cp-immunity.bsky.social

How a junk-food splurge can change your brain activity A short bout of indulgence in fatty, sugary snacks leads to lingering brain-activity changes ― even if it does not cause weight gain.

Five days of indulging in chocolate bars, crisps and other junk foods can lead to lingering changes in brain activity, a study shows1. The resulting brain patterns are similar to those seen in people who have obesity.

https://go.nature.com/3F61B4o

This work is possible due to generous support from @dfg.de @sfb1454.bsky.social @immunosens.bsky.social @alzassociation.bsky.social @jpnd @dzne.science

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer's disease progression - PubMed Activation of the NLRP3 inflammasome has been implicated in the pathogenesis of Alzheimer's disease (AD) via the release of IL-1β and ASC specks. However, whether NLRP3 is involved in pathways beyond ...

This follows on from our recent finding that #NLRP3 controls how #microglia use glutamine generating specific metabolites that modulate cell activity, therefore we set out to summarise the latest research on microglial immunometabolism from the last 2 years 🧠

pubmed.ncbi.nlm.nih.gov/39904338/

Neuroinflammation and immunometabolism in neurodegenerative diseases - PubMed This review highlights the recent studies that have significantly contributed to our understanding of the metabolic dysregulation observed in activated microglia in conditions such as AD, unveiling no...

Happy to share our first review from the McManus lab! 🥳
Special thanks to my PhD student & 1st author @nehalonkar.bsky.social & our co-author & collaborator Eicke Latz 📄
We summarise the key role of #metabolism on microglial function in health & #neurodegeneration 🧠
pubmed.ncbi.nlm.nih.gov/39936491/

2nd Brazilian-German Immunology Workshop
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.office’at’uni-mainz.de) or Bernardo Franklin (franklin’at’uni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.

*Job Opportunity*

Prof. Dominic Lemken is seeking a PhD candidate to research Consumer Behavior and Food Choices as part of our SFB!

If you are passionate about #ConsumerBehavior and #FoodEconomics find out more here:
www.uni-bonn.de/de/universit...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

Another fantastic shot from @roisinmcmanus.bsky.social at the mechanisms of activation and modulation of the #NLRP3 inflammasome! Congratulations to the McManus team at the @dzne.science and my dear friends at the iii @unibonn.bsky.social! Fantastic work!

www.cell.com/immunity/ful...

Assistant or Associate Professor: Therapeutic targets for Alzheimer’s Temple University in Philadelphia is recruiting for a Assistant or Associate Professor - Tenure Track Faculty to work on seeking Therapeutic targets for Alzheimer's Disease.

Temple University @temple.edu in Philadelphia is recruiting for a Assistant or Associate Professor - Tenure Track Faculty to work on seeking Therapeutic targets for Alzheimer's Disease. Closing date: 9th March

www.dementiaresearcher.nihr.ac.uk/job/assistan...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

🎉 Huge congratulations to @roisinmcmanus.bsky.social and Michael Heneka on this exciting study uncovering a novel role for NLRP3 in regulating microglial metabolism and phagocytosis to promote Alzheimer’s disease progression www.cell.com/immunity/abs...

Tau Global Conference | Alzheimer’s Association Leading experts from academia, industry, philanthropy and government will meet to address the future of tau research. Learn more and register.

Join us along with The Rainwater Charitable Foundation and CurePSP for #Tau2025, Apr. 24-25 in London or online! Be a part of the conversation as leading experts work to address the future of tau research. Register now: alz.org/Tau

Oh I’m not going this year 🙈 have another appointment. Hope we can catch up soon!

Thank you Steph! Looking forward to seeing what other tricks NLRP3 has up its sleeves 🥼🧠 delighted you’ve taken this on 💪

Lab Findings Support the Concept that Reducing Neuroinflammation Could Help Fight Alzheimer’s New insights into immune cells in the context of neurodegeneration.

Congratulations to @roisinmcmanus.bsky.social from DZNE in Bonn on her newly published paper in Immunity:
"NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression"

👉 doi.org/10.1016/j.im...

👉 www.dzne.de/en/news/pres...

Centre Director: UK Dementia Research Institute at Cardiff The UK Dementia Research Institute are seeking an outstanding established academic to take the position of Centre Director, at the level of Clinical or non-Clinical Professor.

The UK Dementia Research Institute @UKDRI is seeking an outstanding established academic to take the position of Centre Director, at the level of Clinical or non-Clinical Professor at Cardiff University. Closing date: 20th March

www.dementiaresearcher.nihr.ac.uk/job/centre-d...